全文获取类型
收费全文 | 522篇 |
免费 | 31篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 24篇 |
妇产科学 | 1篇 |
基础医学 | 103篇 |
口腔科学 | 2篇 |
临床医学 | 26篇 |
内科学 | 85篇 |
皮肤病学 | 55篇 |
神经病学 | 10篇 |
特种医学 | 72篇 |
外科学 | 33篇 |
综合类 | 50篇 |
预防医学 | 14篇 |
眼科学 | 2篇 |
药学 | 62篇 |
中国医学 | 1篇 |
肿瘤学 | 17篇 |
出版年
2022年 | 1篇 |
2021年 | 1篇 |
2020年 | 3篇 |
2019年 | 6篇 |
2018年 | 4篇 |
2017年 | 3篇 |
2016年 | 9篇 |
2015年 | 3篇 |
2014年 | 10篇 |
2013年 | 7篇 |
2012年 | 23篇 |
2011年 | 19篇 |
2010年 | 15篇 |
2009年 | 8篇 |
2008年 | 28篇 |
2007年 | 21篇 |
2006年 | 18篇 |
2005年 | 20篇 |
2004年 | 20篇 |
2003年 | 12篇 |
2002年 | 10篇 |
2001年 | 8篇 |
2000年 | 14篇 |
1999年 | 13篇 |
1998年 | 35篇 |
1997年 | 22篇 |
1996年 | 25篇 |
1995年 | 14篇 |
1994年 | 17篇 |
1993年 | 20篇 |
1992年 | 18篇 |
1991年 | 16篇 |
1990年 | 15篇 |
1989年 | 24篇 |
1988年 | 18篇 |
1987年 | 7篇 |
1986年 | 10篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 6篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1972年 | 1篇 |
1971年 | 3篇 |
1968年 | 2篇 |
排序方式: 共有560条查询结果,搜索用时 15 毫秒
21.
DK Bilku AR Dennison TC Hall MS Metcalfe G Garcea 《Annals of the Royal College of Surgeons of England》2014,96(1):15-22
INTRODUCTION
Surgical stress in the presence of fasting worsens the catabolic state, causes insulin resistance and may delay recovery. Carbohydrate rich drinks given preoperatively may ameliorate these deleterious effects. A systematic review was undertaken to analyse the effect of preoperative carbohydrate loading on insulin resistance, gastric emptying, gastric acidity, patient wellbeing, immunity and nutrition following surgery.METHODS
All studies identified through PubMed until September 2011 were included. References were cross-checked to ensure capture of cited pertinent articles.RESULTS
Overall, 17 randomised controlled trials with a total of 1,445 patients who met the inclusion criteria were identified. Preoperative carbohydrate drinks significantly improved insulin resistance and indices of patient comfort following surgery, especially hunger, thirst, malaise, anxiety and nausea. No definite conclusions could be made regarding preservation of muscle mass. Following ingestion of carbohydrate drinks, no adverse events such as apparent or proven aspiration during or after surgery were reported.CONCLUSIONS
Administration of oral carbohydrate drinks before surgery is probably safe and may have a positive influence on a wide range of perioperative markers of clinical outcome. Further studies are required to determine its cost effectiveness. 相似文献22.
23.
目的探讨蜂胶对糖尿病伤口愈合的作用及其机制。方法采用荧光电泳法,检测不同葡萄糖浓度(5、25mmol/L)和不同蜂胶浓度(10、50、100、200μg/ml)处理的体外培养的人成纤维细胞及单核巨噬细胞系的基质金属蛋白酶MMP-9蛋白的表达。结果高浓度葡萄糖(25mmol/L)状态下,MMP-9表达增加,但与低浓度(5mmol/L)比较,差异无统计学意义。蜂胶可显著降低MMP-9的表达,并呈剂量依赖性(P〈.05)。结论高糖能增加单核巨噬细胞系及成纤维细胞MMP-9的表达,可能会影响糖尿病患者伤口的愈合。蜂胶可抑制这些细胞MMP-9的表达,有益于细胞基质的积聚,从而有益于糖尿病患者伤口的愈合。 相似文献
24.
Matthias Christgen MD PhD Oleg Gluz MD Nadia Harbeck MD Ronald E. Kates PhD Mieke Raap MD Henriette Christgen Michael Clemens MD Wolfram Malter MD Benno Nuding MD Bahriye Aktas MD Sherko Kuemmel MD Toralf Reimer MD Andrea Stefek MD Petra Krabisch MD Marianne Just MD Doris Augustin MD Monika Graeser MD Frederick Baehner MD Rachel Wuerstlein MD Ulrike Nitz MD Hans Kreipe MD the West German Study Group PlanB Investigators 《Cancer》2020,126(22):4847-4858
25.
Nicole Schoepke Riccardo Asero Andr Ellrich Marta Ferrer Ana Gimenez‐Arnau Clive E. H. Grattan Thilo Jakob George N. Konstantinou Ulrike Raap Per Stahl Skov Petra Staubach Arno Kromminga Ke Zhang Carsten Bindslev‐Jensen Alvaro Daschner Tamar Kinaciyan Edward F. Knol Michael Makris Nadine Marrouche Peter Schmid‐Grendelmeier Gordon Sussman Elias Toubi Martin K. Church Marcus Maurer 《Allergy》2019,74(12):2427-2436
26.
S2k Guidelines for the diagnosis and treatment of chronic pruritus – update – short version
下载免费PDF全文
![点击此处可从《Journal der Deutschen Dermatologischen Gesellschaft》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Sonja Ständer Claudia Zeidler Matthias Augustin Gudrun Bayer Andreas E. Kremer Franz J. Legat Peter Maisel Thomas Mettang Martin Metz Alexander Nast Volker Niemeier Ulrike Raap Gudrun Schneider Hartmut F. Ständer Petra Staubach Markus Streit Elke Weisshaar 《Journal der Deutschen Dermatologischen Gesellschaft》2017,15(8):860-872
Associated with a host of different diseases, pruritus is a cardinal symptom that poses an interdisciplinary diagnostic and therapeutic challenge. Over time, that symptom may progress independently of the initial cause, thus losing its function as a warning sign and turning into a clinically relevant disease of its own. In Germany, approximately 13.5 % of the general population are affected by chronic pruritus, with an incidence of 7 %. All forms of chronic pruritus require targeted treatment consisting of (a) diagnosis and management of the underlying disease, (b) dermatological treatment of primary or secondary (for example, dry skin, scratch lesions) symptoms, (c) symptomatic antipruritic treatment, and (d) psychological/psychotherapeutic treatment in case of an underlying or associated psychological or psychosomatic condition. Medical care of patients with chronic pruritus should therefore include an interdisciplinary approach, in particular with respect to diagnosis and therapy of the underlying disease as well as in terms of the management of treatment and adverse events. The objective of the present interdisciplinary guidelines is to define and standardize diagnostic and therapeutic procedures in patients with chronic pruritus. This is a short version of the current S2 guidelines on chronic pruritus. The long version may be found at www.awmf.org . 相似文献
27.
28.
29.
Lotte K Vogel Mona S?b? Camilla F Skjelbred Kathrine Abell Esben DK Pedersen Ulla Vogel Elin H Kure 《BMC cancer》2006,6(1):176
Background
It has recently been shown that overexpression of the serine protease, matriptase, in transgenic mice causes a dramatically increased frequency of carcinoma formation. Overexpression of HAI-1 and matriptase together changed the frequency of carcinoma formation to normal. This suggests that the ratio of matriptase to HAI-1 influences the malignant progression. The aim of this study has been to determine the ratio of matriptase to HAI-1 mRNA expression in affected and normal tissue from individuals with colorectal cancer adenomas and carcinomas as well as in healthy individuals, in order to determine at which stages a dysregulated ratio of matriptase/HAI-1 mRNA is present during carcinogenesis. 相似文献30.
Background: General anaesthesia (GA) for cardiac magnetic resonance imaging (MRI) in patients with congenital heart disease (CHD) is challenging for the anaesthesiologist. 相似文献