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101.
J. Quentin Clemens 《Current Bladder Dysfunction Reports》2009,4(3):176-180
In urologic practice, it is common to assign a specific diagnosis based on the presence of a set of characteristic symptoms.
Examples of such symptom-based conditions include overactive bladder, lower urinary tract symptoms, chronic prostatitis/chronic
pelvic pain syndrome, and interstitial cystitis/painful bladder syndrome. No objective diagnostic tests clearly differentiate
between these conditions, and all are diagnoses of exclusion that are assigned after ruling out other identifiable etiologies
for the symptoms (eg, urinary tract infection, bladder cancer). This article reviews the characteristic symptoms that define
each condition and highlights the significant degree of overlap that exists between them. 相似文献
102.
Aortic bypass surgery for asymptomatic patients awaiting a kidney transplant: A word of caution
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103.
Total nasal reconstruction with 3D custom made porous titanium prosthesis and free thoracodorsal artery perforator flap: A case report
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Quentin Qassemyar MD PhD Nathaniel Assouly MD Yoni Madar MD Stéphane Temam MD PhD Frédéric Kolb MD PhD 《Microsurgery》2018,38(5):567-571
Total nasal reconstruction is a challenging surgical procedure which usually involves a free flap, forehead flap, and cartilage grafts. In certain failure situations where patients do not accept the idea of anaplastology, possibilities become very limited. We report the case of a patient who underwent several reconstruction steps with multiple failures including free and local flaps and cartilage harvests which showed recurrent episodes of necrosis and infection leading to melting and collapse of reconstructed structures. Furthermore, the patient did not want any anaplastological rehabilitation. We proposed to the patient an innovative method that consists to print a three‐dimensional custom‐made porous titanium prosthesis, based on the original shape of his nose, to replace the cartilage support. This implant was first inserted in a thoracodorsal artery perforator flap for primary integration before the free transfer of the complete structure, two months later. The free transfer was successful without any complication. A stable reconstruction and satisfying result was obtained. The patient did not want additional surgical improvement 24 months post‐operatively, and resumed his professional activities. The possibility of using three‐dimensional custom titanium prostheses to replace the bone and cartilage support seems to be an interesting alternative for patients in the failure situation of nasal reconstruction. 相似文献
104.
Pierre?Kalfon Karine?Baumstarck Philippe?Estagnasie Marie-Agnès?Geantot Audrey?Berric Georges?Simon Bernard?Floccard Thomas?Signouret Mohamed?Boucekine Mélanie?Fromentin Martine?Nyunga Achille?Sossou Marion?Venot René?Robert Arnaud?Follin Juliette?Audibert Anne?Renault Ma?té?Garrouste-Orgeas Olivier?Collange Quentin?Levrat Isabelle?Villard Didier?Thevenin Julien?Pottecher René-Gilles?Patrigeon Nathalie?Revel Coralie?Vigne Elie?Azoulay Olivier?Mimoz Pascal?Auquier 《Intensive care medicine》2017,43(12):1829-1840
Purpose
Critically ill patients are exposed to stressful conditions and experience several discomforts. The primary objective was to assess whether a tailored multicomponent program is effective for reducing self-perceived discomfort.Methods
In a cluster-randomized two-arm parallel trial, 34 French adult intensive care units (ICUs) without planned interventions to reduce discomfort were randomized, 17 to the arm including a 6-month period of program implementation followed by a 6-month period without the program (experimental group), and 17 to the arm with an inversed sequence (control group). The tailored multicomponent program consisted of assessment of ICU-related self-perceived discomforts, immediate and monthly feedback to healthcare teams, and site-specific tailored interventions. The primary outcome was the overall discomfort score derived from the 16-item IPREA questionnaire (0, minimal, 100, maximal overall discomfort) and the secondary outcomes were the discomfort scores of each IPREA item. IPREA was administered on the day of ICU discharge with a considered timeframe from the ICU admission until ICU discharge.Results
During a 1-month assessment period, 398 and 360 patients were included in the experimental group and the control group, respectively. The difference (experimental minus control) of the overall discomfort score between groups was ? 7.00 (95% CI ? 9.89 to ? 4.11, p < 0.001). After adjustment (age, gender, ICU duration, mechanical ventilation duration, and type of admission), the program effect was still positive for the overall discomfort score (difference ? 6.35, SE 1.23, p < 0.001) and for 12 out of 16 items.Conclusions
This tailored multicomponent program decreased self-perceived discomfort in adult critically ill patients. Trial Registration: Clinicaltrials.gov Identifier NCT02442934.105.
106.
SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae
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Dubois V Poirel L Arpin C Coulange L Bebear C Nordmann P Quentin C 《Antimicrobial agents and chemotherapy》2004,48(11):4466-4469
A clinical strain of Klebsiella pneumoniae carried the bla(SHV-49) gene, encoding a novel inhibitor-resistant beta-lactamase of pI 7.6, derived from SHV-1 by the single substitution M69I. It also harbored a gene differing from bla(SHV-11) by four silent mutations and coding for a penicillinase. Both genes were chromosome located and might represent either a species-specific gene or an acquired resistance gene. 相似文献
107.
108.
High genetic stability of integrons in clinical isolates of Shigella spp. of worldwide origin
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Dubois V Parizano MP Arpin C Coulange L Bezian MC Quentin C 《Antimicrobial agents and chemotherapy》2007,51(4):1333-1340
Over a 12-year period, 68 Shigella strains (31 S. sonnei, 30 S. flexneri, 4 S. dysenteriae, and 3 S. boydii strains) were collected in a French University Hospital from the stools of patients who generally had a recent history of travel to various parts of the world (91%), particularly Africa (67%). These strains were often resistant (streptomycin, spectinomycin, trimethoprim, tetracycline, and sulfonamides, 66 to 84%; ampicillin and chloramphenicol, 34 to 38%; nalidixic acid, 4%) and even multiresistant (87%), and they generally carried integrons (81%) of class 1 (21%), class 2 (47%), or both (13%). Class 1 integrons were associated with ampicillin resistance due to the production of an OXA-30 beta-lactamase in S. flexneri and S. dysenteriae. Class 2 integrons were associated with trimethoprim resistance in S. sonnei. Class 1 and class 2 integrons were inserted within transposons Tn21 and Tn7, respectively, themselves located on the bacterial chromosome, except in one strain. Class 1 integrons showed an atypical organization consisting of the insertion sequence IS1 at the 3' end instead of the typical 3' conserved segment and two blaOXA-30 and aadA1 gene cassettes, despite the absence of epidemiological relationships between the strains, and an apparently functional integrase. Class 2 integrons showed the same albeit classical organization with the three dfrA1, sat, and aadA1 gene cassettes. Occasionally, the 3' end was deleted and the aadA1 gene cassette was unexpressed. Thus, integrons contributed only in part to the multidrug resistance of the Shigella strains. The highly conserved organization of integrons might be related to their location within mobile genetic superstructures. 相似文献
109.
Anne P. Cameron Christina Lewicky-Gaupp Abigail R. Smith Brian T. Helfand John L. Gore J. Quentin Clemens Claire C. Yang Nazema Y. Siddiqui H. Henry Lai James W. Griffith Victor P. Andreev Gang Liu Kevin Weinfurt Cindy L. Amundsen Catherine S. Bradley John W. Kusek Ziya Kirkali 《The Journal of urology》2018,199(4):1023-1031