Etanercept对糖尿病牙周炎大鼠糖尿病病情的影响

目的 观察TNF-α抑制剂Etanercept对实验性糖尿病牙周炎大鼠糖尿病病情的影响.方法 取12周龄wistar大鼠30只.腹腔内一次性注射STZ诱导糖尿病.结扎糖尿病大鼠牙颈部建立牙周炎模型.成模后的糖尿病牙周炎大鼠均分为对照组(给予安慰剂皮下注射)和实验组[给予Etanercept(25mg,2次/周)皮下注射].观察比较两组大鼠的牙周组织和血糖、糖化血清蛋白(GSP)的变化.结果 对照组大鼠可见深牙周袋,牙槽骨表面可见破骨细胞和骨吸收陷窝;实验组大鼠牙龈上皮固有层炎症浸润减轻,牙槽骨表面可见少量破骨细胞.对照组大鼠血糖和GSP值呈上升趋势,第8周血糖到达到(23.53±4.97)mmoI,L;GSP值达到(296.40±57.43)μ mol/L;实验组大鼠第2、4、8周时的血糖和GSP值均明显低于对照组(P<0.05),第8周达到最佳治疗效果,血糖值回落至(10.13±2.05)mmol/L,GSP值降为(143.89±24.86)μ mol/L.结论 Etanercept能明显抑制糖尿病牙周炎大鼠的糖尿病进程,尤以远期效果为好.     

试用敷、擦、服三法治癌之回顾

将敷法、擦法、服法相结合治疗癌症,能取得一定效果。     

帕金森病患者用药依从性管理策略的研究进展

本文就国内外帕金森病患者用药依从性的管理策略进行综述,旨在探索更综合、有效的管理方案,为临床护理工作提供参考,也为帕金森病患者用药管理的深入研究进行铺垫。     

外科综合治疗顽固性梅尼埃病的临床观察

目的通过外科流程治疗顽固性梅尼埃病的远期临床观察,评价梅尼埃病外科流程治疗对眩晕发作控制的有效性。方法 20例顽固性、活动性梅尼埃病患者根据眩晕发作的情况依次采取低压脉冲治疗、内淋巴囊减压术及三个半规管阻塞术治疗。运用症状卡进行眩晕发作和活动状况的评测。结果 20例顽固性、活动性梅尼埃病患者平均104个月观察期内采用单纯低压脉冲治疗有效控制眩晕为17例,比例为85%;低压脉冲治疗+内淋巴囊减压术有效控制眩晕为2例,比例为10%;低压脉冲治疗+内淋巴囊减压术+三个半规管阻塞术有效控制眩晕为1例,比例为5%。结论对于顽固性梅尼埃病眩晕发作的控制需要外科流程化、综合性的治疗和远期观察。     

参苓白术散联合西药治疗溃疡性结肠炎的Meta分析

[目的]系统评价参苓白术散联合西药治疗溃疡性结肠炎(UC)的临床疗效。[方法]计算机检索中国知网(1982~2015)、万方(2001~2015)、维普(1989~2015)、读秀(1996~2015)、PUBMED(1991~2015)、PLoS公共医学科学图书馆(1991~2015)、PMC美国国家医学图书馆生命科学期刊(1991~2015)等数据库,收集参苓白术散联合西药治疗UC的随机对照试验(RCT),由2位评价者独立按照纳入与排除标准筛选文献、提取资料和评价质量后,采用RevMan5.3软件进行Meta分析。[结果]共纳入10个文献,包含884例患者。参苓白术散联合西药组在治疗UC的总有效率[OR=3.30,95%CI(2.25,4.82),P0.01]、显效率[OR=2.02,95%CI(1.54,2.65),P0.01]均优于对照组,有效率与对照组相近[OR=1.08,95%CI(0.78,1.50),P=0.64],无效率则低于对照组[OR=0.30,95%CI(0.21,0.44),P0.01]。差异有显著统计学意义。漏斗图分析不对称,表明存在发表性偏倚。[结论]参苓白术散联合西药组治疗UC的疗效优于对照组。     

Porphyria cutanea tarda and Sjogren's syndrome

Porphyria cutanea tarda is prevalent in connective tissue disease, common in systemic lupus erythematosus. However, the co-existence of primary sjogren''s syndrome and porphyria cutanea tarda is rare and poses diagnostic and therapeutic challenges. We report a case of porphyria cutanea tarda associated with primary sjogren''s syndrome.     

Adolescents’ Exposure to Disasters and Substance Use

This paper reviews the impact of exposure to man-made or natural disasters on adolescent substance use. It covers empirical studies published from 2005 to 2015 concerning (a) the scope of the problem, (b) vulnerable groups and risk and protective factors, and (c) evidence-based interventions. The review suggests a strong link between adolescent substance use and exposure to either man-made or natural disaster. Vulnerable groups include adolescents with previous exposure to traumatic events, living in areas that are continually exposed to disasters, and ethnic minorities. Risk and protective factors at the individual, familial, community, and societal levels are described based on the bioecological model of mass trauma. Given that mass trauma is unfortunately a global problem, it is important to establish international interdisciplinary working teams to set gold standards for comparative studies on the etiology for adolescent substance use in the context of disasters.