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91.
Maier-Redelsperger M; Noguchi CT; de Montalembert M; Rodgers GP; Schechter AN; Gourbil A; Blanchard D; Jais JP; Ducrocq R; Peltier JY 《Blood》1994,84(9):3182-3188
Intracellular hemoglobin S (HbS) polymerization is most likely to be the primary determinant of the clinical and biologic manifestations of sickle cell disease (SCD). Fetal hemoglobin (HbF) does not enter the HbS polymer and its intracellular expression in sickle erythrocytes inhibits polymerization. HbF levels, high at birth but decreasing thereafter, protect the newborn from the clinical manifestations of this hemoglobinopathy. We have measured the sequential changes in HbF, F reticulocytes, and F cells in the first 2 years of life in 25 children with SCD and compared the results with those obtained in 30 normal children (AA). We have also calculated HbF per F cell (F/F cell), the preferential survival of F cells versus non-F cells, as measured by the ratio F cells versus F reticulocytes (FC/FR) and polymer tendency at 40% and 70% oxygen saturation. HbF levels decreased from about 80.4% +/- 4.0% at birth to 9.2% +/- 2.9% at 24 months. During this time, we observed a regular decrease of the F reticulocytes and the F cells. The kinetics of the decline of F/F cell was comparable with the decline of HbF, rapid from birth (mean, 27.0 +/- 3.6 pg) to 12 months of age (mean, 8.5 +/- 1.5 pg) and then slower from 12 to 24 months of age (mean, 6.2 +/- 1.0 pg) in the SCD children. In the AA children, the decrease in HbF, due to changes in both numbers of F cells and F/F cell, was more precipitous, reaching steady-state levels by 10 months of age. Calculated values for mean polymer tendency in the F-cell population showed that polymerization should begin to occur at 40% oxygen saturation at about 3 months and increase progressively with age, whereas polymerization at 70% oxygen saturation would not occur until about 24 months. These values correspond to HbF levels of 50.8% +/- 10.8% and 9.2% +/- 2.9%, respectively, and F/F cell levels of 15.6 +/- 4.5 pg and 6.2 +/- 1.0 pg, respectively. In the non--F-cell population, polymerization was expected at birth at both oxygen saturation values. Three individuals had significantly greater predicted polymerization tendency than the remainder of the group because of early decreases in HbF. These individuals in particular, the remainder of the cohort, as well as other recruited newborns, will be studied prospectively to ascertain the relationship among hematologic parameters, which determine polymerization tendency and the various clinical manifestations of SCD. 相似文献
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本文对生理载荷条件下(正常步态、爬楼梯和日常活动的混态载倚)骨水泥髋臼假体(牛髋骨试件)的失效机制进行研究.试验中利用髋关节仿真试验机施加生理载倚,利用人工仿真关节液来模拟体内生理环境,以测试髋臼假体的生命周期.在试验中通过微CT扫描仪观测并记载破坏的进程,并在试验结束后使用显微镜进行验证.结果表明,在所有载荷条件下,骨水泥-骨的界面松解是导致假体失效的原因,在体外环境条件下界面松解发生在髋臼窝中心的后上部区域,在体内生理环境下界面松解则发生在髋臼窝的所有区域.因此.模拟人体内部生理条件的试验环境是必需的,同时也确定髋臼假体的失效来自于力学和生物学因素的共同作用. 相似文献
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The hereditary pancreatitis gene maps to long arm of chromosome 7 总被引:11,自引:0,他引:11
Le Bodic L; Bignon JD; Raguenes O; Mercier B; Georgelin T; Schnee M; Soulard F; Gagne K; Bonneville F; Muller JY; Bachner L; Ferec C 《Human molecular genetics》1996,5(4):549-554
Hereditary pancreatitis (HP) is an autosomal dominant disorder with
incomplete penetrance characterized by recurring episodes of severe
abdominal pain often presenting in childhood. Although this disorder has
only been recently described, about 100 families have been documented
worldwide. The pathophysiology of this disorder is unknown. Here, a large
French family of 147 individuals (47 of whom were affected) from a
four-generation kindred with HP has been examined and a genome segregation
analysis of highly informative microsatellite markers has been performed.
Linkage has been found between HP and six chromosome 7q markers. Maximal
two point lod scores between HP and D7S 640, D7S 495, D7S 684, D7S 661, D7S
676 and D7S 688 were 4.00 (theta = 0.143), 5.85 (theta = 0.143), 4.91
(theta = 0.156), 8.58 (theta = 0.077), 8.28 (theta = 0.060), 4.40 (theta =
0.169), respectively. Multipoint linkage data combined with recombinant
haplotype analysis indicated that the most likely order is: D7S 640-D7S
495-D7S 684-D7S 661-D7S 676-D7S 688, with the HP gene situated in the
underlined region. As in all families reported in the literature, the
clinical presentation of the disease is identical to the presentation of
sporadic cases, one could expect that the knowledge of the HP gene could be
a clue to pancreatitis in general. Based on its map position, this is the
first step towards the positional cloning of the Hereditary Pancreatitis
Gene (HPG).
相似文献