真皮导管瘤一例

患者男,61岁,因头枕部丘疹3年就诊。患者于3年前无明显诱因下发现枕部丘疹,无自觉症状,后缓慢增大。否认病程中出血、溃疡、脱屑等。体检：一般情况好,各系统检查未见异常。皮肤科检查：枕部见一枚黄豆大小丘疹,直径约9 mm,淡红色,境界清晰,表面光滑,质地坚实（图1A）……     

A First-Principles Study on the Hydration Behavior of (MgO)n Clusters and the Effect Mechanism of Anti-Hydration Agents

Magnesia-based refractory is widely used in high-temperature industries; its easy hydration is, however, a key concern in refractory processing. Understanding the hydration mechanism of MgO will help in solving its hydration problem. Herein, the hydration behavior of (MgO)_n (n = 1–6) at the molecular level and the effect mechanisms of several anti-hydration agents on the hydration of (MgO)₄ were investigated with first-principles calculations. The results indicated that the following: (1) The smaller the (MgO)_n cluster size, the more favorable the hydration of MgO and the tendency to convert into Mg(OH)₂ crystal; (2) Anti-hydration agents can coordinate with the unsaturated Mg atom of (MgO)₄ to form a bond, increasing the coordination number of Mg, thus reducing its activity when reacting with H₂O; (3) The greater the number of −COOH groups and the longer the chain length in the anti-hydration agents, the better its effect of inhibiting the hydration of MgO. These findings could enhance the understanding of the mechanism of hydration of MgO and provide theoretical guidance for the design of novel anti-hydration agents.     

Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales

Aggression is a common and complex social behavior that is associated with violence and mental diseases. Although sex differences were observed in aggression, the neural mechanism for the effect of sex on aggression behaviors remains unclear, especially in specific subscales of aggression. In this study, we investigated the effects of sex on aggression subscales, gray matter volume (GMV), and functional connectivity (FC) of each insula subregion as well as the correlation of aggression subscales with GMV and FC. This study found that sex significantly influenced (a) physical aggression, anger, and hostility; (b) the GMV of all insula subregions; and (c) the FC of the dorsal agranular insula (dIa), dorsal dysgranular insula (dId), and ventral dysgranular and granular insula (vId_vIg). Additionally, mediation analysis revealed that the GMV of bilateral dIa mediates the association between sex and physical aggression, and left dId–left medial orbital superior frontal gyrus FC mediates the relationship between sex and anger. These findings revealed the neural mechanism underlying the sex differences in aggression subscales and the important role of the insula in aggression differences between males and females. This finding could potentially explain sexual dimorphism in neuropsychiatric disorders and improve dysregulated aggressive behavior.     

葛根素治疗不稳定型心绞痛的临床观察

目的 :探讨葛根素在治疗不稳定型心绞痛 ( U AP)中的疗效。方法 :入选 UAP患者 98例 ,分为葛根素组 5 0例 ,对照组 48例。葛根素组中使用剂量为 40 0 m g,对照组用硝酸甘油 10 mg。然后比较两组疗效。结果 :两组总有效率及症状控制时间无显著性差异。结论 :葛根素是一种治疗不稳定型心绞痛的安全、有效的中药。     

CCL2-2518λ������̬������֢��������71�͸�Ⱦ������о�

??Objective To investigate the relationship between CCL2-2518A/G gene polymorphism and severity of enterovirus 71??EV71?? infection. Methods CCL2 gene polymorphism in 188 EV71-infected patients and 235 healthy controls were detected by the improved multiplex ligation detection reaction technique??iMLDR??. The level of CCL2 in two groups was determined by enzyme-linked immunosorbent assay??ELISA??. Results No significant differences were found in the distribution of genotype CCL2-2518A/G between EV71-infected patients and the healthy control group??P??0.05??. The G allele??genotypes AG or GG?? in the CCL2-2518A/G??P??0.001?? was more frequent in patients with severe EV71 infection. The level of CCL2 in infected patients was higher than that of the heathy controls ??P??0.05???? the severe cases had higher level of CCL2 than that of the slight cases and healthy controls??P??0.05??. The level of CCL2 in GG gene group was significantly higher than that in AG gene group and the level of CCL2 in AG gene group was significantly higher than that in AA gene group.The people with CCL2-2518G allele??GG+AG?? had higher level of CCL2 than those only with CCL2-2518A allele??AA????P??0.05??. Conclusion The G carrier of the CCL2-2518A/G is found to be associated with severity of EV71 infection??and could be susceptibility factors in the development of EV71 infection.     

多囊卵巢综合征合并代谢综合征中抗苗勒管激素水平与窦卵泡计数的相关性分析

目的：分析多囊卵巢和代谢综合征中抗苗勒管激素(AMH)水平与窦卵泡计数(AFC)之间的相关性。方法：选取2018年3月～2021年3月我院收治的119例多囊卵巢合并代谢综合征患者和同期于我院健康体检的60例健康女性分别作为观察组、对照组。采集并比较两组一般资料、基础指标以及AMH、AFC,分析多囊卵巢和代谢综合征中AMH、AFC之间相关性,并采用ROC曲线分析AMH、AFC对多囊卵巢合并代谢综合征发生的预测价值。结果：与对照组对比,观察组BMI、WHR、SBP、DBP、T、FPG、TG、FINS、HOMA-IR升高,HDL降低,两组比较具有统计学差异。与对照组比较,观察组AMH、AFC升高,两组比较具有统计学差异。AMH与T、FPG、TG、FINS、HOMA-IR之间均表现为正相关,AMH与HDL之间表现为负相关。AFC与T、FPG、TG、FINS、HOMA-IR之间均表现为正相关,AFC与HDL之间表现为负相关。AMH与APC之间表现为正相关。ROC曲线显示,与AMH、AFC单项预测对比,两项联合对多囊卵巢合并代谢综合征发生的预测价值较高。结论：多囊卵巢和代谢综合征中AMH、AFC水...     

The Effect of Acidity Coefficient on the Crystallization Properties and Viscosity of Modified Blast Furnace Slag for Mineral Wool Production

The crystallization and viscosity of modified blast furnace slag are key factors in fiber forming conditions. In this paper, the crystallization behavior of modified blast furnace slag under continuous cooling conditions was studied by differential scanning calorimetry, and its crystallization kinetics with different acidity coefficients were established. On this basis, the evolution law of the crystallization phase and the influence of crystallization on the viscosity of modified blast furnace slag with different acidity coefficients were analyzed. The results indicated that the crystallization phases of slag with acidity coefficients of 1.05 and 1.20 were, respectively, Melilite and Anorthite. During the cooling process at the acidity coefficient of 1.05, the critical rates of precipitation of Melilite and Anorthite were 50 °C/s and 20 °C/s, respectively, while they were 20 °C/s and 15 °C/s, respectively, at the acidity coefficient of 1.20. With the increase of the acidity coefficient, the crystal growth mode of slag changed from two-dimensional and three-dimensional mixed crystallization to surface nucleation and one-dimensional crystallization. The crystallization activation energy of slag with acidity coefficients of 1.05 and 1.20 were 698.14 kJ/mol and 1292.50 kJ/mol, respectively. In addition, the change trend of viscosity was related to crystal size and content.     

Unravelling the alkali transport properties in nanocrystalline A3OX (A = Li,Na, X = Cl,Br) solid state electrolytes. A theoretical prediction

Transport properties of the halogeno-alkali oxides A₃OX (A = Li, Na, X = Cl, Br) nanocrystalline samples with the presence of ∑3(111) grain boundaries were computed using large-scale molecular dynamic simulations. Results on the diffusion/conduction process show that these nanocrystalline samples are characterized with higher activation energies as compared to previous theoretical studies, but closer to experiment. Such a performance can be attributed to the larger atomic density at the ∑3(111) grain boundary regions within the nanocrystals. Despite a minor deterioration of transport properties of the mixed cation Li₂NaOX and Na₂LiOX samples, these halogeno-alkali oxides can also be considered as good inorganic solid electrolytes in both Li- and Na-ion batteries.

Transport properties of the halogeno-alkali oxides A₃OX (A = Li, Na, X = Cl, Br) nanocrystalline samples with the presence of ∑3(111) grain boundaries were computed using large-scale molecular dynamic simulations.