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41.
The present study has analysed the DNA adducts formed in SENCAR mouse
epidermis following topical application of 7-methylbenz[a]anthracene (7-
MBA). Mice were treated with 400 nmol of 7-MBA, which represents an
initiating dose of this hydrocarbon for SENCAR mice. DNA adducts were
analysed 24 h after topical application of the hydrocarbon by 32P-
postlabeling coupled with either HPLC analysis or an improved TLC procedure
giving better resolution of DNA adducts through the use of a D6 solvent
[isopropanol:4N NH4OH (1:1)] following D5. Twenty-four hours after topical
application of 400 nmol 7-MBA, the level of total covalent binding was 0.37
+/- 0.07 pmol/mg DNA as determined by 32P- postlabeling. This level of
binding correlated well with the relative tumor initiating activity of this
hydrocarbon compared to 7,12- dimethylbenz[a]anthracene (6.4 +/- 0.01
pmol/mg DNA) and dibenz[a,j]anthracene (0.03 +/- 0.01 pmol/mg DNA).
Analysis of the 32P- labeled 3',5'-diphosphodeoxyribonucleosides by HPLC
and TLC revealed the presence of deoxyguanosine (dGuo) and deoxyadenosine
(dAdo) adducts formed from both the anti- and syn-bay-region diol-epoxides
of 7-MBA (anti- and syn-7-MBADEs). The major DNA adduct derived from 7-MBA
in mouse epidermis was tentatively identified as (+) anti-7-MBADE-trans-N2-
dGuo. In addition, a minor dGuo adduct derived from the bay-region syn-
diol-epoxide of 7-MBA was detected as well as a minor dAdo adduct from this
diol-epoxide. Another minor dAdo adduct was also detectably present which
arose from either the anti- or syn-diol epoxide. Furthermore, several
unidentified DNA adducts were present in both HPLC and TLC chromatograms of
DNA samples from 7-MBA-treated mice. These results are discussed in terms
of the role of specific 7-MBA-DNA adducts in tumor initiation by this
hydrocarbon.
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42.
Giant cell tumor of bone: radiographic changes following local excision and allograft replacement 总被引:1,自引:0,他引:1
The authors retrospectively evaluated the clinical records and radiographs obtained from 41 patients who had giant cell tumor of bone and who were treated by local resection and allograft replacement. Postoperative complications developed in 41% of the patients. However, the eventual clinical outcome was considered to be satisfactory in 85% of all cases. There were no instances of tumor recurrence, and surprisingly, postoperative arthritis was not a major problem. The major complications encountered were infection and allograft fracture; bone infection accounted for most of the clinical failures. All infections were associated with the increasing soft-tissue swelling and bone resorption detected on radiographic studies. Other radiographic parameters that were associated with an increased rate of complications included osteopenia, increased periosteal reaction, and decreased bone formation at the host-donor junction site. The clinical outcome was distinctly less favorable in those cases in which the patient had had a pathologic fracture or a previous resection, or in whom the graft was implanted at the distal radius. 相似文献
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Hayel Tuncel Ronald Boellaard Emma M Coomans Erik FJ de Vries Andor WJM Glaudemans Paula Kopschina Feltes David V García Sander CJ Verfaillie Emma E Wolters Steven P Sweeney J Michael Ryan Magnus Ivarsson Berkley A Lynch Patrick Schober Philip Scheltens Robert C Schuit Albert D Windhorst Peter P De Deyn Bart NM van Berckel Sandeep SV Golla 《Journal of cerebral blood flow and metabolism》2021,41(6):1338
[11C]UCB-J is a novel radioligand that binds to synaptic vesicle glycoprotein 2A (SV2A). The main objective of this study was to determine the 28-day test–retest repeatability (TRT) of quantitative [11C]UCB-J brain positron emission tomography (PET) imaging in Alzheimer’s disease (AD) patients and healthy controls (HCs). Nine HCs and eight AD patients underwent two 60 min dynamic [11C]UCB-J PET scans with arterial sampling with an interval of 28 days. The optimal tracer kinetic model was assessed using the Akaike criteria (AIC). Micro-/macro-parameters such as tracer delivery (K1) and volume of distribution (VT) were estimated using the optimal model. Data were also analysed for simplified reference tissue model (SRTM) with centrum semi-ovale (white matter) as reference region. Based on AIC, both 1T2k_VB and 2T4k_VB described the [11C]UCB-J kinetics equally well. Analysis showed that whole-brain grey matter TRT for VT, DVR and SRTM BPND were –2.2% ± 8.5, 0.4% ± 12.0 and –8.0% ± 10.2, averaged over all subjects. [11C]UCB-J kinetics can be well described by a 1T2k_VB model, and a 60 min scan duration was sufficient to obtain reliable estimates for both plasma input and reference tissue models. TRT for VT, DVR and BPND was <15% (1SD) averaged over all subjects and indicates adequate quantitative repeatability of [11C]UCB-J PET. 相似文献
46.
Hartimath SV Draghiciu O. Daemen T Nijman H.W. van Waarde A. Dierckx R.A.J.O. de Vries E.F.J. 《Molecular imaging and biology》2020,22(4):883-890
Molecular Imaging and Biology - Chemokine CXCL12 and its receptor CXCR4 are constitutively overexpressed in human cancers. The CXCL12-CXCR4 signaling axis plays an important role in tumor... 相似文献
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Intercalary bone allografts: radiographic evaluation 总被引:2,自引:0,他引:2
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