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Ashok Apurva Niyogi Devayani Ranganathan Priya Tandon Sandeep Bhaskar Maheema Karimundackal George Jiwnani Sabita Shetmahajan Madhavi Pramesh C. S. 《Surgery today》2020,50(4):323-334
Surgery Today - Esophageal cancer surgery, comprising esophagectomy with radical lymphadenectomy, is a complex procedure associated with considerable morbidity and mortality. The enhanced recovery... 相似文献
64.
Nadeem Siddiqui Md. Jawaid Akhtar M. Shahar Yar Priya Ahuja Waquar Ahsan Sharique Ahmed 《Medicinal chemistry research》2014,23(11):4915-4925
A series of 3-(4-substitutedphenyl)-N-(5-(4-substitutedphenyl-1,3,4-oxadiazol-2-yl)but-2-enamide were synthesized using pharmacophoric elements for in vivo anticonvulsant activity yielding two potent candidates (4d and 4j) in the Phase I and Phase II screening employing maximal electroshock seizure and subcutaneous pentylenetetrazole test having minimal neurotoxicity. Their Phase II screen depicted an increment of nearly 2–10 times for MES and 7–67 folds for scPTZ in the therapeutic index and protective index—the two mainstays in the drug discovery. 相似文献
65.
Sara E. Murray Priya R. Pathak Sarah C. Schaefer Herbert Chen Rebecca S. Sippel 《World journal of surgery》2014,38(3):542-548
Background
The aim of the present study was to investigate the incidence of sleep disturbance and insomnia in patients with primary hyperparathyroidism (PHPT), and to evaluate the effect of parathyroidectomy.Methods
A questionnaire was prospectively administered to adult patients with PHPT who underwent curative parathyroidectomy over an 11-month period. The questionnaire, administered preoperatively and 6 months postoperatively, included the Insomnia Severity Index (ISI) and eight additional questions regarding sleep pattern. Total ISI scores range from 0 to 28, with >7 signifying sleep difficulties and scores >14 indicating clinical insomnia.Results
Of 197 eligible patients undergoing parathyroidectomy for PHPT, 115 (58.3 %) completed the preoperative and postoperative questionnaires. The mean age was 60.0 ± 1.2 years and 80.0 % were women. Preoperatively, 72 patients (62.6 %) had sleep difficulties, and 29 patients (25.2 %) met the criteria for clinical insomnia. Clinicopathologic variables were not predictive of clinical insomnia. There was a significant reduction in mean ISI score after parathyroidectomy (10.3 ± 0.6 vs 6.2 ± 0.5, p < 0.0001). Postoperatively, 79 patients (68.7 %) had an improved ISI score. Of the 29 patients with preoperative clinical insomnia, 21 (72.4 %) had resolution after parathyroidectomy. Preoperative insomnia patients had an increase in total hours slept after parathyroidectomy (5.4 ± 0.3 vs 6.1 ± 0.3 h, p = 0.02), whereas both insomnia patients and non-insomnia patients had a decrease in the number of awakenings (3.7 ± 0.4 vs 1.9 ± 0.2 times, p = 0.0001).Conclusions
Sleep disturbances and insomnia are common in patients with PHPT, and the majority of patients will improve after curative parathyroidectomy. 相似文献66.
Graham Cocks Sarah Curran Priya Gami Dafe Uwanogho Aaron R. Jeffries Annie Kathuria Walter Lucchesi Victoria Wood Rosemary Dixon Caroline Ogilvie Thomas Steckler Jack Price 《Psychopharmacology》2014,231(6):1079-1088
Until now, models of psychiatric diseases have typically been animal models. Whether they were to be used to further understand the pathophysiology of the disorder, or as drug discovery tools, animal models have been the choice of preference in mimicking psychiatric disorders in an experimental setting. While there have been cellular models, they have generally been lacking in validity. This situation is changing with the advent of patient-specific induced pluripotent stem cells (iPSCs). In this article, we give a methodological evaluation of the current state of the iPS technology with reference to our own work in generating patient-specific iPSCs for the study of autistic spectrum disorder (ASD). In addition, we will give a broader perspective on the validity of this technology and to what extent it can be expected to complement animal models of ASD in the coming years. 相似文献
67.
Authors Priya Nambisan Donna Lamkin Carrie DeLong 《Online Journal of Public Health Informatics》2014,6(2)
Telemonitoring is being increasingly used to provide services to patients with
developmental disabilities in residential community settings. The objective of
this study is to assess the feasibility, benefits and challenges of using
telemonitoring for aging patients with developmental disabilities. We also
assess the benefits and challenges of telemonitoring for the caregivers of these
patients. Focus groups and questionnaire-based surveys were used to collect data
from patients and caregivers. The study found that telemonitoring was feasible
and beneficial for the aging with developmental disabilities, albeit for those
who are moderate to high functioning. It was not beneficial or feasible for
those with very low functional capabilities. The study found that telemonitoring
was beneficial towards providing more independence, more self-confidence in
carrying out daily activities, and more knowledge regarding their disease. The
study also found that telemonitoring was useful for caregivers to better
understand their patients and their needs, better coordinate the services
delivered, and to enhance the satisfaction of caregiving. The discussions
include limitations of using quantitative methods in this type of setting. 相似文献
68.
Raches Ella Krishna Mohan Vadrevu Harsh Jogdand Sai Prasad Siddharth Reddy Vamshi Sarangi Brunda Ganneru Gajanan Sapkal Pragya Yadav Priya Abraham Samiran Panda Nivedita Gupta Prabhakar Reddy Savita Verma Sanjay Kumar Rai Chandramani Singh Sagar Vivek Redkar Chandra Sekhar Gillurkar Balram Bhargava 《The Lancet infectious diseases》2021,21(5):637-646
69.
Dongguang Wei Mohamed M. Zaid Matthew H. Katz Laura R. Prakash Michael Kim Ching-Wei D. Tzeng Jeffrey E. Lee Anshuman Agrawal Asif Rashid Hua Wang Gauri Varadhachary Robert A. Wolff Eric P. Tamm Priya R. Bhosale Anirban Maitra Eugene J. Koay Huamin Wang 《Pancreatology》2021,21(1):200-207
ObjectivesTumor size measurement is critical for accurate tumor staging in patients with pancreatic ductal adenocarcinoma (PDAC). However, accurate tumor size measurement is challenging in patients who received neoadjuvant therapy before resection, due to treatment-induced fibrosis and tumor invasion beyond the grossly identified tumor area. In this study, we evaluated the correlation between the tumor size and tumor volume measured on post-therapy computed tomography (CT) scans and the pathological measurement. Also, we investigated the correlation between these measurements and clinicopathological parameters and survival.Materials and methodsRetrospectively, we evaluated 343 patients with PDAC who received neoadjuvant therapy, followed by pancreaticoduodenectomy and had pre-operative pancreatic protocol CT imaging. We measured the longest tumor diameter (RadL) and the radiological tumor volume (RadV) on the post-therapy CT scan, then we categorized RadL into four radiologic tumor stages (RTS) based on the current AJCC staging (8th edition) protocol and RadV based on the median. Pearson correlation or Spearman’s coefficient (δ), T-test and ANOVA was used to test the correlation between the radiological and pathological measurement. Chi-square analysis was used to test the correlation with the tumor pathological response, lymph-node metastasis and margin status and Kaplan-Meier and Cox-proportional hazard for survival analysis. P-value < 0.05 was considered significant.ResultsAs a continuous variable, RadL showed a positive linear correlation with the post-therapy pathologic tumor size in the overall patient population (Pearson correlation coefficient: 0.72, P < 0.001) and RadV (δ: 0.63, p < 0.0001). However, there was no correlation between RadL and pathologic tumor size in patients with ypT0 and those with pathologic tumor size of ≤1.0 cm. Post-therapy RTS and RadV group correlated with ypT stage, tumor response grades using either CAP or MDA grading system, distance of superior mesenteric artery margin and tumor recurrence/metastasis.ConclusionAlthough RadL tends to understage ypT in PDAC patients who had no radiologically detectable tumor or small tumors (RTS0 or RTS1), radiologic measurement of post-therapy tumor size may be used as a marker for the pathologic tumor staging and tumor response to neoadjuvant therapy. 相似文献
70.
Patel Nayana U. Lind Kimberly E. Garg Kavita Crawford David Werahera Priya N. Pokharel Sajal S. 《Abdominal imaging》2019,44(2):705-712
Abdominal Radiology - To assess the diagnostic accuracy of PI-RADS v2 categories ≥ 3 to detect clinically significant prostate cancer (csPCa) against histopathology of... 相似文献