全文获取类型
收费全文 | 305篇 |
免费 | 15篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 14篇 |
妇产科学 | 6篇 |
基础医学 | 43篇 |
口腔科学 | 10篇 |
临床医学 | 23篇 |
内科学 | 81篇 |
皮肤病学 | 4篇 |
神经病学 | 21篇 |
特种医学 | 4篇 |
外科学 | 19篇 |
综合类 | 3篇 |
预防医学 | 17篇 |
眼科学 | 16篇 |
药学 | 27篇 |
中国医学 | 1篇 |
肿瘤学 | 30篇 |
出版年
2023年 | 3篇 |
2022年 | 2篇 |
2021年 | 16篇 |
2020年 | 8篇 |
2019年 | 21篇 |
2018年 | 14篇 |
2017年 | 7篇 |
2016年 | 4篇 |
2015年 | 12篇 |
2014年 | 21篇 |
2013年 | 24篇 |
2012年 | 35篇 |
2011年 | 39篇 |
2010年 | 13篇 |
2009年 | 13篇 |
2008年 | 23篇 |
2007年 | 25篇 |
2006年 | 12篇 |
2005年 | 13篇 |
2004年 | 9篇 |
2003年 | 3篇 |
2002年 | 2篇 |
2001年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有321条查询结果,搜索用时 31 毫秒
61.
Natural human antibody responses to Plasmodium vivax apical membrane antigen 1 under low transmission and unstable malaria conditions in Sri Lanka
下载免费PDF全文
![点击此处可从《Infection and immunity》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Wickramarachchi T Premaratne PH Perera KL Bandara S Kocken CH Thomas AW Handunnetti SM Udagama-Randeniya PV 《Infection and immunity》2006,74(1):798-801
Plasmodium vivax apical membrane antigen 1, an important malaria vaccine candidate, was immunogenic during natural malaria infections in Sri Lanka, where low transmission and unstable malaria conditions prevail. Antibody prevalence increased with exposure in areas where malaria was or was not endemic. A marked isotype switch to cytophilic (immunoglobulin G1 [IgG1]/IgG3) antibodies was evident with increasing exposure exclusively in residents from areas of endemicity. 相似文献
62.
Preethi G. Anantharaju Bandi Deepa Reddy Mahesh A. Padukudru CH. M. Kumari Chitturi Manjunath G. Vimalambike 《Cancer biology & therapy》2017,18(7):492-504
Histone deacetylases (HDACs), which modulate the expression of genes, are potential therapeutic targets in several cancers. Targeted inhibition of HDAC prevents the expression of oncogenes thereby help in the treatment of cancers. Hence, several pharmaceutical companies developed inhibitors of HDAC and tested them in preclinical models and in clinical trials. SAHA (suberanilohydroxamic acid) is one such HDAC inhibitor developed for treating breast and colorectal carcinomas. However, due to poor efficacy in clinical trials the utility of SAHA for treating cancers was discouraged. Similarly another HDAC inhibitor Trichostatin-A (TSA) also showed promising results in clinical trials but exhibited severe adverse effects, which dampened the interest of using this molecule for cancer treatment. Therefore, search for developing a potent HDAC inhibitor with minimal side effects still continues. Hence, in this study we have screened benzoic acid and benzoic acid derivatives with hydroxylic (-OH) groups and methoxy (-OCH3) groups for their efficacy to bind to the TSA binding site of HDAC using molecular docking studies. Molecules that showed much stronger affinity (than TSA) to HDAC were tested for inhibiting HDAC expressing cultured cancer cells. DHBA but not Dimethoxy Benzoic Acid (DMBA) inhibited HDAC activity, leading to cancer cell growth inhibition through the induction of ROS and cellular apoptosis mediated by Caspase-3. In addition, DHBA arrested cells in G2/M phase of the cell cycle and elevated the levels of sub-G0-G1 cell population. In summary, results of this study report that DHBA could be a strong HDAC inhibitor and inhibit cancer cell growth more effectively. 相似文献
63.
Xavier Forns Samuel S Lee Joaquin Valdes Sabela Lens Reem Ghalib Humberto Aguilar Franco Felizarta Tarek Hassanein Holger Hinrichsen Diego Rincon Rosa Morillas Stefan Zeuzem Yves Horsmans David R Nelson Yao Yu Preethi Krishnan Chih-Wei Lin Jens J Kort Federico J Mensa 《The Lancet infectious diseases》2017,17(10):1062-1068
64.
65.
Raghu P Tran TA Rady P Tyring S Carlson JA 《The American Journal of dermatopathology》2012,34(7):e97-e102
ABSTRACT:: Chronic papillomatous dermatitis (CPD) is a stoma site complication due to chronic irritant contact dermatitis. Papillomatosis can also arise in the setting of Human Papillomavirus (HPV) infection or chronic lymphedema (elephantiasis). Herein, we report the case of a 57-year-old female who presented with a papillomatous growth surrounding a loop ileostomy suspected to be recurrent ovarian serous carcinoma. Excisional biopsy demonstrated nevus sebaceous (NS)-like organoid hyperplasia with koilocytes overlying a dermal scar that exhibited lymphangiectases. Polymerase chain reaction and sequencing for HPV DNA detected HPV 16. In situ hybridization for high-risk HPV DNA showed punctate nuclear pattern in the keratinocytes populating the NS-like hyperplasia indicating integrated HPV 16 DNA. No recurrence has been observed 11 months postexcision. Reports of CPD have documented a spectrum of reactive epidermal hyperplasias including pseudoepitheliomatous, verrucous, papillomatous, syringofibroadenomatous, and rudimentary follicular hyperplasias. HPV DNA has been detected in 3 of 4 CDP cases tested to date and in authentic NS. We postulate that localized lymphedema secondary to scarring coupled with chronic epidermal irritation and inflammation allowed for latent HPV infection to manifest as CPD with NS-like cutaneous hyperplasia. 相似文献
66.
67.
Mohammad‐Ali Yazdani Abyaneh Preethi Raghu Kenneth Kircher Heinz Kutzner Kortz Alison John Andrew Carlson 《Journal of cutaneous pathology》2015,42(10):746-756
Vasculitis associated with sarcoid granulomas is an uncommon phenomenon. A 72‐year‐old female presented with an expanding region of circumscribed alopecia and scalp atrophy of 2 months duration. Biopsy showed non‐caseating granulomas, dermal thinning, loss of follicles, fibrosis and muscular vessels disrupted by mixed lymphocyte, macrophage and giant‐cell infiltrates. Affected vessels had loss and fragmentation of the elastic lamina, fibrous replacement of their walls and luminal stenosis (endarteritis obliterans). Dermal and vascular advential intralymphatic granulomas and lymphangiectases were found by D2‐40 expression, suggesting lymphatic obstruction and poor antigen clearance. No evidence of a post‐zoster eruption, systemic sarcoidosis or systemic giant‐cell arteritis was found. Two years later, prednisone had halted – but not reversed – progression of her alopecia. Review of the literature showed two types of vasculitis associated with sarcoid granulomas: (i) acute, self‐limited leukocytoclastic vasculitis and (ii) chronic granulomatous vasculitis (GV). Persistence of non‐degradable material or antigen contributes to the pathogenesis of granulomatous inflammation. In this case, lymphatic obstruction probably impeded clearance of nonimmunologic and/or immunologic stimuli permitting and sustaining the development of sarcoid granulomas and sarcoid GV, ultimately causing scarring alopecia and cutaneous atrophy. 相似文献
68.
Jarmila Heissigerová David Callanan Marc D. de Smet Sunil K. Srivastava Michala Karkanová Olga Garcia-Garcia Sibel Kadayifcilar Yilmaz Ozyazgan Robert Vitti Kristine Erickson Aditya Athanikar Karen Chu Namrata Saroj Preethi A. Sundaram Rafael Varona Valerie Corp-dit-Genti Ronald Buggage Yenchieh Cheng Quan Dong Nguyen 《Ophthalmology》2019,126(3):428-437
69.
70.
Preethi Balasubramanian Dan Kai Seeram Ramakrishna 《Journal of biomaterials science. Polymer edition》2013,24(14):1660-1675
Myocardial infarction is the major cause of death in many industrialized nations as it leads to end-stage heart failure. Tissue engineering (TE) approaches for treatment of the infarcted tissue have gained huge attention over the recent years and research in this direction mainly aims for the optimization of a biomaterial scaffold with suitable cell source for tissue regeneration. In this regard, we fabricated completely natural polymeric scaffolds using fibrinogen and gelatin in two different weight ratios and performed cross-linking [Fib/Gel(1:4)-CL; Fib/Gel(2:3)-CL] while cross-linked fibrinogen scaffolds were used as the control. The fiber diameters of the fabricated scaffolds were obtained in the range of 150–300?nm. Chemical characterization of the scaffolds confirmed the presence of both the proteins and showed the absence of any chemical reactions between them. The tensile strength and the stiffness values of Fib/Gel(1:4)-CL matrices were found to be 0.0125 and 0.46?MPa, respectively, which were much similar to the innate properties of the native myocardium. Cell culture studies using human cardiomyocytes revealed higher cell proliferation on Fib/Gel(1:4)-CL scaffolds compared to cell proliferation on Fib/Gel(2:3)-CL scaffolds, which was even higher than the cell proliferation on cross-linked fibrinogen scaffolds. Moreover, the cardiomyocytes seeded on composite substrates expressed the typical functional cardiac proteins such as alpha-actinin, troponin I, connexin-43, and myosin heavy chain, and could be potential for application in cardiac TE. 相似文献