全文获取类型
收费全文 | 1001篇 |
免费 | 80篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 20篇 |
妇产科学 | 32篇 |
基础医学 | 142篇 |
口腔科学 | 17篇 |
临床医学 | 72篇 |
内科学 | 263篇 |
皮肤病学 | 31篇 |
神经病学 | 64篇 |
特种医学 | 45篇 |
外科学 | 189篇 |
综合类 | 2篇 |
预防医学 | 64篇 |
眼科学 | 37篇 |
药学 | 35篇 |
中国医学 | 3篇 |
肿瘤学 | 73篇 |
出版年
2023年 | 11篇 |
2022年 | 44篇 |
2021年 | 62篇 |
2020年 | 41篇 |
2019年 | 36篇 |
2018年 | 46篇 |
2017年 | 29篇 |
2016年 | 41篇 |
2015年 | 33篇 |
2014年 | 30篇 |
2013年 | 51篇 |
2012年 | 71篇 |
2011年 | 99篇 |
2010年 | 55篇 |
2009年 | 37篇 |
2008年 | 37篇 |
2007年 | 73篇 |
2006年 | 66篇 |
2005年 | 50篇 |
2004年 | 57篇 |
2003年 | 48篇 |
2002年 | 51篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 4篇 |
1998年 | 1篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1975年 | 3篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有1094条查询结果,搜索用时 15 毫秒
81.
Gherase F Miron A Zagnat M Hăncianu M Stănescu U Grigorescu E 《Revista medico-chirurgical?? a Societ????ii de Medici ??i Naturali??ti din Ia??i》2004,108(1):177-180
In this study a qualitative and quantitative analysis of flavonoids from flower heads of Achillea species belonging to the A. millefolium L. group was achieved. Rutin, apigenin-7-O-glucoside, luteolin-7-O-glucoside in the methanolic extract of A. collina J. Becker ex Reichenb., A. pratensis Saukel et Langer, A. millefolium L. were determined by comparison of their Rf-TLC data with those obtained from reference flavonoids. Apart from flavonoid glycosides, the free aglycones, apigenin and luteolin were identified by TLC. Flavonoidic compounds have been detected by spectrophotometric method in concentrations of appr. 0.5-1.8% in plant materials. 相似文献
82.
Dehelean C Năstase V Dragomirescu A Hegheş A Dinte E 《Revista medico-chirurgical?? a Societ????ii de Medici ??i Naturali??ti din Ia??i》2004,108(1):169-172
This study presents the toxic effects of a very known and used compound in pharmaceutical products and from cosmetic market, a detergent (surface-active) anionic. The presented data underlined the effects of an ointment base with sodium lauryl sulfate, with various concentrations of this detergent, respectively: 0.5%, 1% and 3%, in a long term utilization of this, on an animal model with Sprague Dawley rats. 相似文献
83.
State A 《Oftalmologia (Bucharest, Romania : 1990)》2004,48(2):30-32
A case of grouped pigmentation of the retina with unilateral localisation is presented. The positive diagnosis of this congenital abnormality is decided upon the aspects of the retinal grouped pigmentations and it is confirmed using additional test: angiography, electrophysiological methods, visual field test and adaptometry. 相似文献
84.
An unsupervised approach to identify molecular phenotypic components influencing breast cancer features 总被引:2,自引:0,他引:2
Selaru FM Yin J Olaru A Mori Y Xu Y Epstein SH Sato F Deacu E Wang S Sterian A Fulton A Abraham JM Shibata D Baquet C Stass SA Meltzer SJ 《Cancer research》2004,64(5):1584-1588
To discover a biological basis for clinical subgroupings within breast cancers, we applied principal components (PCs) analysis to cDNA microarray data from 36 breast cancers. We correlated the resulting PCs with clinical features. The 35 PCs discovered were ranked in order of their impact on gene expression patterns. Interestingly, PC 7 identified a unique subgroup consisting of estrogen receptor (ER); (+) African-American patients. This group exhibited global molecular phenotypes significantly different from both ER (-) African-American women and ER (+) or ER (-) Caucasian women (P < 0.001). Additional significant PCs included PC 4, correlating with lymph node metastasis (P = 0.04), and PC 10, with tumor stage (stage 2 versus stage 3; P = 0.007). These results provide a molecular phenotypic basis for the existence of a biologically unique subgroup comprising ER (+) breast cancers from African-American patients. Moreover, these findings illustrate the potential of PCs analysis to detect molecular phenotypic bases for relevant clinical or biological features of human tumors in general. 相似文献
85.
BACKGROUND: Increased attention has been given to alpha-synuclein aggregation in nonsynucleinopathies because alpha-synuclein-containing Lewy bodies (LBs) influence symptoms. However, the spectrum of disorders in which secondary inclusions are likely to occur has not been defined. Amygdala neurons commonly develop large numbers of secondary LBs, making it a practical region for studying this phenomenon. OBJECTIVE: To characterize the spectrum of diseases associated with LB formation in the amygdala of neurodegenerative disease and control cases. DESIGN: An autopsy series of 101 neurodegenerative disease and 34 aged control cases. Using immunohistochemistry studies, we examined the amygdala for alpha-synuclein aggregates. RESULTS: Lewy bodies were often abundant in classic Pick disease, argyrophilic grain disease, Alzheimer disease, and dementia with LBs but not in cases with amygdala degeneration lacking tau-based inclusions, control cases, preclinical disease carriers, or degenerative diseases lacking pathologic involvement of the amygdala. The exposed alpha-synuclein epitopes were similar in all cases containing LBs. CONCLUSIONS: Abnormal alpha-synuclein aggregation in the amygdala is disease selective, but not restricted to disorders of alpha-synuclein and beta-amyloid. Our data are compatible with the notion that tau aggregates predispose neurons to develop secondary LBs. 相似文献
86.
87.
Duyn A Van Eijkeren M Kenter G Zwinderman K Ansink A 《Acta obstetricia et gynecologica Scandinavica》2002,81(4):351-355
BACKGROUND: Only a small proportion of cervical cancer recurrences is detected during routine follow-up. We investigated which percentage of recurrences is detected during follow-up, which diagnostic tools are helpful to detect recurrent disease and which factors are of prognostic significance once recurrent disease has been established in patients treated for cervical cancer stage IB-IVA. METHODS: Characteristics of the primary tumor, characteristics of recurrent disease and follow-up were collected retrospectively from clinical records of 277 patients who achieved a complete remission of at least 3 months after primary treatment for cervical cancer in 1992, 1993 and 1994 in three university hospitals in the Netherlands. RESULTS: Of 277 patients, 47 (17%) developed recurrent disease; this was most often detected after self-referral (45%), and in 32% during routine follow-up. Survival did not differ significantly between these two groups. The presence of symptoms (87%) was the most important first abnormal test result leading to diagnosis of recurrence. In univariate analysis, disease-free interval (DFI) and treatment modality were significant prognostic factors for crude survival of recurrence. However, treatment modality varied considerably and the subgroups were small. Therefore, multivariate analysis was not feasible and clinically valid conclusions could not be drawn. CONCLUSIONS: In only 32% of all cases, recurrence was detected during a scheduled follow-up visit. In the majority of patients, recurrent cervical cancer was detected by symptoms (87%). In recurrent disease, DFI was a prognostic factor for survival. 相似文献
88.
Duyn A Van Eijkeren M Kenter G Zwinderman K Ansink A 《Acta obstetricia et gynecologica Scandinavica》2002,81(8):759-763
BACKGROUND: Only a small proportion of cervical cancer recurrences is detected during routine follow-up. We investigated which percentage of recurrences is detected during follow-up, which diagnostic tools are helpful to detect recurrent disease and which factors are of prognostic significance once recurrent disease has been established in patients treated for cervical cancer stage IB-IVA. METHODS: Characteristics of the primary tumor, characteristics of recurrent disease and follow-up were collected retrospectively from clinical records of 277 patients who achieved a complete remission of at least 3 months after primary treatment for cervical cancer in 1992, 1993 and 1994 in three university hospitals in the Netherlands. RESULTS: Of 277 patients, 47 (17%) developed recurrent disease; this was most often detected after self-referral (45%), and in 32% during routine follow-up. Survival did not differ significantly between these two groups. The presence of symptoms (87%) was the most important first abnormal test result leading to diagnosis of recurrence. In univariate analysis, disease-free interval (DFI) and treatment modality were significant prognostic factors for crude survival of recurrence. However, treatment modality varied considerably and the subgroups were small. Therefore, multivariate analysis was not feasible and clinically valid conclusions could not be drawn. CONCLUSIONS: In only 32% of all cases, recurrence was detected during a scheduled follow-up visit. In the majority of patients, recurrent cervical cancer was detected by symptoms (87%). In recurrent disease, DFI was a prognostic factor for survival. 相似文献
89.
90.
Ungureanu D Filip C Artenie A Artenie R 《Revista medico-chirurgical?? a Societ????ii de Medici ??i Naturali??ti din Ia??i》2003,107(1):66-71
3-Hydroxy-3-methyl-coenzyme A reductase (HMG-CoA reductase) which transforms 3-hydroxy-3-methylglutaril-coenzyme A (HMG-CoA) in mevalonate, is the rate limiting enzyme in cholesterol biosynthesis. In our study, from HMG-CoA reductase's known inhibitors, we used simvastatin (ZOCOR), which is a semi synthetic derivative of the second generation. The study was performed on 25 subjects (12 men and 12 women) aged 33-67 yo, with hypercholesterolemia, which have received simvastatin, 10 mg daily for 8 months. Under treatment with simvastatin we obtained a significant decrease of total cholesterol (p < 0.0001) and an improvement of enzymatic antioxidant parameters: superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT). In conclusion, simvastatin therapy determines a significant decrease in SOD, GPx, CAT, and an increase in CAT/SOD and GPx/SOD ratios. 相似文献