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131.
In vitro and in vivo selectin-blocking activities of sulfated lipids and sulfated sialyl compounds 总被引:2,自引:0,他引:2
Mulligan MS; Warner RL; Lowe JB; Smith PL; Suzuki Y; Miyasaka M; Yamaguchi S; Ohta Y; Tsukada Y; Kiso M; Hasegawa A; Ward PA 《International immunology》1998,10(5):569-575
There is accumulating evidence that sulfated lipids, sulfated
oligosaccharides and other sulfated compounds are reactive with selectins
in a manner that interferes with selectin interactions with their natural
ligands. In the report we describe the ability of sulfated lipids
(sulfatides and gangliosides) and multimeric forms of sulfated sialic acid
to block binding of P- and E-selectin-Ig to neutrophils. The in vivo
ability of these compounds to block lung injury in rats following i.v.
infusion of purified cobra venom factor (CVF), which induces injury that is
L- and P-selectin dependent, was also determined as well as effects on
recruitment of neutrophils, as measured by lung myeloperoxidase. There was
a significant correlation between the ability of sulfated lipids and sialyl
compounds to interfere in vitro with P-selectin-Ig binding to neutrophils
and to protect against P-selectin-dependent acute lung injury induced by
CVF. The biological effects of these sulfated compounds were also
associated with diminished accumulation of neutrophils. The protective
effects of these compounds may be linked to their ability to interfere with
P- selectin binding to counter-receptors on neutrophils.
相似文献
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Raúl Parrón Cambero Félix Tomé Bermejo Andrés Barriga Martín Juan A. Herrera Molpeceres Elisa Poveda Samuel Pajares Cabanillas 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2008,18(5):361-364
The aim of the study was to analyse the validity of the Ottawa rules for the X-ray request in A&E for ankle and midfoot injuries
in paediatric patients. An observational and prospective study was carried out applying the Ottawa rules to patients attending
the Accident and Emergency (A&E) department in Toledo, due to ankle or midfoot injuries from the 1 July 2003 to the 1 February
2004. A total number of 190 patients were included in this study and 29 of these were found to have a fracture. Assessment
of the ankle and/or midfoot injuries was made by the orthopaedic junior or senior staff, applying the Ottawa rules. An X-ray
request was made for every patient seen, regardless of the Ottawa rules results. The results showed that the sensitivity for
the Ottawa rules was 96.9% (95% CI, 94–99.1%). The negative predictive value was 96.6% (95% CI, 96.5–100.1%). The specificity
was 36% (95% CI, 29.2–42.9%). The positive predictive value was 21.4% (95% CI, 15.5–27.2%). It can be concluded that The Ottawa
rules make up valid instrument for the decision of X-ray request in patients under the age of 18 with ankle and/or midfoot
injuries. 相似文献
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Kalman滤波分光光度法同时测定多相脂质体口服液中氟尿嘧啶和尼泊金的含量 总被引:1,自引:0,他引:1
本文提出了对测量值平滑后,用Kalman滤波分光光度法同时测定多相脂质体口服液中氟尿嘧啶和尼泊金的含量,改善了滤波效果,较好地解决了复杂基质存在下多组分的同时测定。用人工合成样考察表明,在269~273nm间滤波结果较好。用分别相当制剂标示量80,100,120%的两组分九种可能组合人工合成样品考查结果表明,氟尿嘧啶和尼泊金的回收率分别为99.3~102.6%和97.8~103.0%;当存在系统误差时,回收率分别为99.4~102.7%和97.0~102.9% 相似文献
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