ISOLATION OF CHROMATIN THREADS FROM THE RESTING NUCLEUS OF LEUKEMIC CELLS

1. A method for the separation of chromatin threads from the resting nucleus of leukemic cells has been described. 2. The isolation of the chromatin strands was accomplished by purely mechanical means, and the separation, including extraction and purification in the centrifuge, required only about 1 hour. 3. Evidence is presented to show that the chromatin strands are morphologically related to the chromosomes, if not identical. 4. It seems probable that, by the present technique, chromatin strands can be obtained from different mammalian tissues for direct microscopical examination and biochemical analysis.     

The Michigan Alcoholism Screening Test and Its Shortened Form: A Meta-Analytic Inquiry Into Score Reliability

Meta-analytic methods provide a framework around which an inquiry into MAST and SMAST score reliability was completed. Of the 470 measurement opportunities observed between 1971 and 2005, 62 (13.2%) were coupled with accurate reliability information. Weighted reliability estimates centered on. 80 suggesting that the MAST and SMAST generally produce scores of similar and adequate reliability for most research purposes. However, the variability of internal consistency estimates shows that at times these tools will not produce reliable scores, particularly among female and nonclinical respondents. Multiple regression equations provide practical guidelines to improve reliability estimates for the future use of these instruments.