全文获取类型
收费全文 | 620篇 |
免费 | 43篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 34篇 |
妇产科学 | 14篇 |
基础医学 | 61篇 |
口腔科学 | 9篇 |
临床医学 | 51篇 |
内科学 | 123篇 |
皮肤病学 | 13篇 |
神经病学 | 34篇 |
特种医学 | 37篇 |
外科学 | 144篇 |
综合类 | 8篇 |
预防医学 | 43篇 |
眼科学 | 4篇 |
药学 | 42篇 |
中国医学 | 4篇 |
肿瘤学 | 30篇 |
出版年
2023年 | 7篇 |
2022年 | 12篇 |
2021年 | 17篇 |
2020年 | 6篇 |
2019年 | 11篇 |
2018年 | 12篇 |
2017年 | 18篇 |
2016年 | 14篇 |
2015年 | 19篇 |
2014年 | 24篇 |
2013年 | 23篇 |
2012年 | 19篇 |
2011年 | 39篇 |
2010年 | 22篇 |
2009年 | 26篇 |
2008年 | 32篇 |
2007年 | 32篇 |
2006年 | 32篇 |
2005年 | 18篇 |
2004年 | 15篇 |
2003年 | 26篇 |
2002年 | 18篇 |
2001年 | 28篇 |
2000年 | 18篇 |
1999年 | 15篇 |
1998年 | 4篇 |
1997年 | 7篇 |
1996年 | 3篇 |
1995年 | 7篇 |
1994年 | 9篇 |
1993年 | 9篇 |
1992年 | 13篇 |
1991年 | 5篇 |
1990年 | 17篇 |
1989年 | 5篇 |
1988年 | 6篇 |
1987年 | 10篇 |
1986年 | 8篇 |
1985年 | 10篇 |
1984年 | 8篇 |
1983年 | 8篇 |
1981年 | 4篇 |
1978年 | 3篇 |
1976年 | 4篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1970年 | 2篇 |
1969年 | 2篇 |
1967年 | 2篇 |
1966年 | 5篇 |
排序方式: 共有668条查询结果,搜索用时 31 毫秒
11.
S.-H. SONG J.-K. LEE M.-J. OH J.-Y. HUR Y.-K. PARK & H.-S. SAW 《International journal of gynecological cancer》2006,16(4):1608-1613
To identify the factors that may predict the progression or persistence of untreated mild dysplasia of the uterine cervix, we performed a retrospective review of 118 patients with histologically verified mild dysplasia who underwent colposcopic biopsies between January 1999 and December 2003. Regression to normal occurred in 70.3%, progression to moderate dysplasia or worse occurred in 11.0%, and persistence of mild dysplasia occurred in 18.7%. In regression/progression analysis, progression of untreated mild dysplasia was 34.5% (10/29) in patients with high viral loads (> or =100 relative light units/positive control [RLU/PC]) and 4.5% (3/67) in those with low viral loads (1 to <100 RLU/PC) and negative human papillomavirus (HPV) tests (P < 0.001). Women with high viral loads had a 13-fold greater chance of progression of untreated mild dysplasia than those with low viral loads and negative HPV tests (CI: 2.494-95.297; P = 0.0022). Those associated with both positive smear and positive HPV test (12/45 = 26.7%) were at a greater risk of progression of untreated mild dysplasia as compared with those with positive smear and negative HPV (0/17 = 0.0%) or those with negative smear and positive HPV test (1/18 = 5.6%). Those with high viral loads and both with positive smear and positive HPV test should be followed closely because of their increased risk of progression of untreated mild dysplasia. 相似文献
12.
Gallardo E. Medina J. Sánchez J. C. Viúdez A. Grande E. Porras I. Ramón y Cajal T. Trigo J. Iglesias L. Capdevila J. 《Clinical & translational oncology》2020,22(2):223-235
Clinical and Translational Oncology - Thyroid carcinoma is the most frequent endocrine malignancy and accounts for around 3% of global cancer incidence. Different histologies and clinical scenarios... 相似文献
13.
Left-right asymmetry is a conserved property in nature and observed in the human body, a property known as cell chirality. Cell chirality is often studied using micropatterned in vitro models. However, micropattern geometry and size often varies across different studies, making it challenging to compare results. Here, we utilized micropatterned RGD-peptide lines on hyaluronic acid hydrogels to investigate the effect of the micropattern width on the exhibited cell chirality bias of brain microvascular endothelial cells. Overall, this cell type exhibited a negative chirality bias on micropatterned lines ranging from 10 μm to 400 μm in width, where the negative bias was most pronounced on the 100 μm wide lines. We also observed that this exhibited chirality bias varied across the line width. This work serves as a guide to determine optimal micropattern width for further investigations on cell chirality bias and its prominence in e.g., disease states or upon exposure to toxic substances.Brain endothelial microvascular cell chirality is dependent on micropattern width and spatial localization. Finding the optimal micropattern width and including only the centre cells in the analysis for chirality-based experiments might improve further experimental results. 相似文献
14.
15.
Jose R. Gonzalez‐Porras Fernando Escalante Emilia Pardal Magdalena Sierra Luis J. Garcia‐Frade Santiago Redondo Maryam Arefi Carlos Aguilar Fernando Ortega Erik de Cabo Rosa M. Fisac Oscar Sanz Carmen Esteban Ignacio Alberca Mercedes Sanchez‐Barba Maria T. Santos Abel Fernandez Tomas J. Gonzalez‐Lopez representing the Grupo de Trombosis y Hemostasia de Castilla y León 《European journal of haematology》2013,91(3):236-241
16.
Melero Tejedor JM Rodríguez Bailón I Such Martínez M Porras Martín C Olalla Mercadé E Espinosa Caliani JS 《Revista espa?ola de cardiología》2000,53(12):1667-1670
Valvular heart disease associated with the use of anorectic agents is a recently described clinical entity. We report the case of a 46-year-old woman with severe regurgitation of the mitral, aortic and tricuspid valves who had been taking fenfluramine and dexfenfluramine for two years. Surgical treatment was required with replacement of three valve by mechanical prostheses. The previous history of treatment with anorectic agents, the echocardiographic morphology of the injured valves and the macroscopic and histopathologic findings strongly suggested an association between the anorectic agents and the valvular disease of the patient. 相似文献
17.
Iglesias LF Zabala y Morales M Marcos G González Eguaras M Vega J Vaccari O Porras Y Montero J 《Revista espa?ola de cardiología》1999,52(2):135-138
Cardiac hydatic cysts are rare and represent 0.5 to 2% of all hydatic cysts in humans, but usually associated with fatal complications. We report a case of a male 27 years old with a hydatid cyst located in left ventricle asymptomatic until rupture. It was diagnosed by two-dimensional echocardiogram in a control. 相似文献
18.
Carlos Isaza Julieta Henao Leonardo Beltrán Liliana Porras Martha Gonzalez Raquel Cruz Angel Carracedo 《Colombia Médica》2013,44(1):19-25
Objective:
Determine the prevalence and compare some genetic markers involved in addictive behavior in a group of addicts to derivative of coca (cocaine/crack) or heroin and a control group of non-addicted people matched for gender, age and ethnicity.Methods:
A 120 addicts and 120 non-addicts Colombian male were surveyed and genotyped for 18 polymorphism of the OPRM1, DRD2, DRD4, SLC6A3, SLC6A4, ABCB1, DβH and CYP2B6 genes. For the identification of alleles markers were used mini-sequencing and fragment multiplex PCR techniques; ethnicity of cases and controls was analyzed with 61 AIMs.Results:
The age of onset use of heroin or coca derivatives (cocaine/crack) was 16.5±6 years and 99.2% of them consume several illicit drugs. It showed that controls and addicts belong to the same ethnic group. Significant differences between addicts and controls in relation to schooling, marital status, social security family history of substance abuse (p <0.001), Int8-VNTR SLC6A3 gene (p= 0.015) and SNP 3435C>T ABCB1 gene (p= 0.001) were found.Conclusion:
The present results indicate that the VNTR- 6R polymorphism of the gene SLC6A3 and the genotype 3435CC in the ABCB1 gene, are both associated with addictive behavior to heroin or cocaine. 相似文献19.
Alejandro Porras Segovia Margarita Guerrero-Jimnez Carmen Maura Carrillo de Albornoz Calahorro Luis Gutierrez-Rojas 《上海精神医学》2021,34(2)
Dandy-Walker syndrome (DWS) is a group of brain malformations which sometimes present with psychotic symptoms. We present the case of a patient diagnosed with Dandy-Walker variant who presented with schizophrenia-like psychosis. A man in his 30s was admitted to an acute psychiatric unit presenting with persecutory delusions, auditory hallucinations and violent behaviour. The MRI performed showed the typical alterations of Dandy-Walker variant: vermian hypoplasia and cystic dilatation of the fourth ventricle. He also suffered from mild intellectual disability. After being treated with olanzapine 10 mg/d for a month, his psychotic symptoms greatly improved and he was discharged. In conclusion, DWS may cause psychosis through a dysfunction in the circuit connecting prefrontal, thalamic and cerebellar areas. The association between these two conditions may contribute to the understanding of the aetiopathogenesis of schizophrenia. 相似文献
20.
Yu-Te Hsu Mt Hartstein Alexander J. Davies Alexander J. Hickey Mun K. Chan Juan Porras Toshinao Loew Sofia V. Taylor Hsu Liu Alexander G. Eaton Matthieu Le Tacon Huakun Zuo Jinhua Wang Zengwei Zhu Gilbert G. Lonzarich Bernhard Keimer Neil Harrison Suchitra E. Sebastian 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(7)