全文获取类型
收费全文 | 890篇 |
免费 | 38篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 43篇 |
妇产科学 | 42篇 |
基础医学 | 136篇 |
口腔科学 | 30篇 |
临床医学 | 86篇 |
内科学 | 160篇 |
皮肤病学 | 18篇 |
神经病学 | 42篇 |
特种医学 | 21篇 |
外科学 | 68篇 |
综合类 | 11篇 |
预防医学 | 52篇 |
眼科学 | 38篇 |
药学 | 122篇 |
中国医学 | 7篇 |
肿瘤学 | 49篇 |
出版年
2024年 | 1篇 |
2023年 | 10篇 |
2022年 | 30篇 |
2021年 | 60篇 |
2020年 | 24篇 |
2019年 | 38篇 |
2018年 | 44篇 |
2017年 | 37篇 |
2016年 | 38篇 |
2015年 | 36篇 |
2014年 | 48篇 |
2013年 | 68篇 |
2012年 | 93篇 |
2011年 | 89篇 |
2010年 | 31篇 |
2009年 | 38篇 |
2008年 | 50篇 |
2007年 | 37篇 |
2006年 | 16篇 |
2005年 | 36篇 |
2004年 | 27篇 |
2003年 | 14篇 |
2002年 | 21篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 4篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1992年 | 3篇 |
1991年 | 5篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1984年 | 1篇 |
排序方式: 共有931条查询结果,搜索用时 15 毫秒
921.
Introduction
The prevalence of cardiovascular diseases, one of the major causes of worldwide mortality, is being increasingly reported. Safer, more effective, and less expensive thrombolytic drugs can possibly overcome the underlying problems associate with current thrombolytic drugs.Methods
A thrombolytic enzyme was purified and characterized from a Streptomyces strain. Carrageenan induced tail-thrombosis mice model was used to evaluate in vivo antithrombotic effect of the enzyme.Results
First 15 N-terminal amino acids of the purified enzyme were IAGGQAIYAGGGRRS, which are significantly different from the reported fibrinolytic enzymes. The enzyme exhibited 14.3 ± 2.3-fold stronger thrombolytic activity than that of plasmin. In carrageenan induced tail-thrombosis model, the enzyme caused reduction in frequency of thrombus. Tail-thrombus of the enzyme treated group was significantly shorter than the physiological saline treated group and the thrombus decrement was correlated with the enzyme dose.Conclusions
The enzyme purified from the Streptomyces strain can be a potential candidate for the treatment of thrombosis. 相似文献922.
Anupma Dwivedi Nikolitsa Nomikou Poonam Singh Nigam Anthony P. McHale 《International journal of medical microbiology : IJMM》2012,302(7-8):293-299
It has been known for some time that the micro-milieu of solid tumours provides an ideal environment for growth of facultative and strictly anaerobic bacteria, and it has been shown that certain species including Lactobacillus and Clostridium can colonise those environments leading to regression of tumour growth. Such observations have given rise to the concept of bacteriolytic therapy where live microorganisms might be employed to colonise the tumour and exert a tumorolytic effect. In choosing such an approach, it would be advantageous to exploit a relatively non-pathogenic strain and provide some form of containment that would enable site-specific injection and minimise dispersion of the microorganism throughout the host. In testing the feasibility of such an approach, we prepared microencapsulated formulations of Lactobacillus casei NCDO 161 and demonstrated that conditioned extra-capsular culture media were toxic to tumour cells in vitro. We further investigated the effects of the microencapsulated formulations on tumour growth in vivo following direct intra-tumoural injection. The study demonstrates significant inhibition of tumour growth in vivo by these formulations and suggests potential therapeutic benefit of this approach in the treatment of solid tumours. 相似文献
923.
Poonam Sharma Gurjinder Kaur Sanjeev Kumar Bhardwaj Gurcharan Kaur 《Brain research bulletin》1998,47(1):1189
We examined the effect of intracerebroventricular (i.c.v.) administration of μ-opioid agonist, morphine, and its antagonist naloxone followed by morphine on the activities of monoamine-metabolizing enzymes, namely tyrosine hydroxylase (TH) and monoamine oxidase (MAO) along with adenosinetriphosphatase (Na+, K+ -ATPase), the enzyme responsible for the maintenance of ionic gradients across the membrane, in seven discrete regions of brain from estrogen- and progesterone-primed ovariectomized rats. TH activity decreased after morphine treatment in some areas such as the median eminence-arcuate region (ME-ARC), the amygdala, and the thalamus, showing statistically significant change. MAO activity increased in all the areas studied, but more appreciable change was observed in medial preoptic area (mPOA), the ME-ARC region, and the cortex. Pronounced increase in Na+, K+ -ATPase enzyme activity was observed after the drug treatment. Naloxone given prior to morphine injection resulted in recovery of the enzyme activities in most of the areas studied. Our study may provide insights into the precise opioidergic modulation of gonadotropin releasing hormone (GnRH) release mechanisms through the involvement of monoaminergic system, elucidating the basis of various neuronal dysfunctions and their management in opioid addicts. 相似文献
924.
Gadwal Ashita Modi Anupama Khokhar Manoj Vishnoi Jeewan Ram Choudhary Ramkaran Elhence Poonam Banerjee Mithu Purohit Purvi 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(1):35-44
International Journal of Clinical Oncology - Galectins are defined as the glycan-binding protein containing either one or two carbohydrate-binding domains and participate in various biological... 相似文献
925.
Sumit Kumar Dharna Yadav Divya Singh Kriti Shakya Brijesh Rathi Poonam 《Reviews in medical virology》2023,33(2):e2419
Junin virus consists of ribonucleic acid as the genome and is responsible for a rapidly changing tendency of the virus. The virus is accountable for ailments in the human body and causes Argentine Haemorrhagic Fever (AHF). The infection is may be transmitted through contact between an infected animal/host and a person, and later between person to person. Prevention of outbreaks of AHF in humans can be a tough practice, as their occurrence is infrequent and unpredictable. In this review, recent information from the past 5 years available on the Junin virus including the risk of its emergence, infectious agents, its pathogenesis in humans, available diagnostic and therapeutic approaches, and disease management has been summarised. Altogether, this article would be highly significant in understanding the mechanistic basis behind virus interaction and other processes during the life cycle. Currently, no specific therapeutic options are available to treat the Junin virus infection. The information covered in this review could be important for finding possible treatment options for Junin virus infections. 相似文献
926.
927.
Transfusion practices during the COVID-19 pandemic: An experience from a hematology daycare in India
Jayastu Senapati Mukul Aggarwal Liji Louis Saleem A. Mirza Pradeep Kumar Rishi Dhawan Jasmita Dass Ganesh K. Vishwanathan Hem Chandra Pandey Poonam Coshic Seema Tyagi Tulika Seth Manoranjan Mahapatra 《Transfusion and apheresis science》2021,60(2):103025
The Coronavirus disease-19 (COVID-19) pandemic has in multiple ways affected healthcare delivery to non?COVID patients throughout the world. Adequate transfusion services are fundamental in ongoing therapy of patients with hematological ailments. We present the transfusion services in the hematology daycare under the department of Hematology and supported by the Blood Bank at our institution for the period 12th April 2020?30th June 2020, which saw the stringent lockdown and unlocking Phase I in India, declared in lieu of the pandemic. A 56 % reduction in total transfusion sessions was observed in 2020 (588 sessions given to 176 patients) compared to 1336 sessions in 516 patients over the same period in 2019. The reductions were seen across the different blood components (packed red blood cells [PRBC]: 585 vs. 1840, platelet rich plasma: 372 vs. 1313, single donor platelet 18 vs. 16), with a significant reduction in the mean PRBC transfused per PRBC transfusion session (1.11 vs 1.99, p<0.001) in 2020, compared to 2019. There were however no major differences in the transfusion practices across the different phases of the lockdown. Our study highlights the detrimental reduction in transfusion services due to the COVID-19 pandemic and related lockdown and showcases the remedial strategies taken to maximize transfusion support to patients during this period. Our observations might help to provide insights to adequately combat possible similar adverse situations in the future. 相似文献
928.
M. Lisa Zhang MD Yurina Miki MBBS Jen-Fan Hang MD Manjiv Vohra MS MBA Stephen Peyton MBBS Patrick J. McIntire MD Christopher J. VandenBussche MD PhD Poonam Vohra MD 《Cancer cytopathology》2021,129(4):264-274
Urinary cytology (UC) is one of the primary diagnostic modalities used for the screening and surveillance of urothelial carcinoma. Despite its widespread use, UC has suffered from a lack of standardized or reproducible criteria and wide interobserver variability, particularly of the designation of atypical urothelial cells. The Paris System for Reporting Urinary Cytology (TPS), published in 2016, aimed to provide a standardized approach for evaluating UC by creating diagnostic categories with specific cytomorphologic criteria. Recent studies have primarily investigated the application of TPS on lower urinary tract specimens and have mostly shown that TPS implementation has improved the performance of UC specimens. Only a few studies have reported the impact of TPS on upper urinary tract (UUT) cytology. Additionally, there is uncertainty as to which cytological features are most predictive of high-grade urothelial carcinoma (HGUC) in the UUT. This review summarizes the literature regarding the utility and performance of UUT cytology and highlights findings before and after the implementation of TPS. 相似文献
929.
930.