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971.
972.
Julien Rohmer Amélie Couteau-Chardon Julie Trichereau Kewin Panel Cyrielle Gesquiere Raouf Ben Abdelali Audrey Bidet Jean-Sébastien Bladé Jean-Michel Cayuela Pascale Cony-Makhoul Vincent Cottin Eric Delabesse Mikaël Ebbo Olivier Fain Pascale Flandrin Lionel Galicier Catherine Godon Nathalie Grardel Aurélien Guffroy Mohamed Hamidou Mathilde Hunault Etienne Lengline Faustine Lhomme Ludovic Lhermitte Irène Machelart Laurent Mauvieux Catherine Mohr Marie-Joelle Mozicconacci Dina Naguib Franck E. Nicolini Jerome Rey Philippe Rousselot Suzanne Tavitian Louis Terriou Guillaume Lefèvre Claude Preudhomme Jean-Emmanuel Kahn Matthieu Groh CEREO GBMHM collaborators 《American journal of hematology》2020,95(11):1314-1323
FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare disease: robust epidemiological data are lacking and reported issues are scarce, of low sample-size and limited follow-up. Imatinib mesylate (IM) is highly efficient but no predictive factor of relapse after discontinuation has yet been identified. One hundred and fifty-one patients with F/P+ MN-eo (143 males; mean age at diagnosis 49 years; mean annual incidence: 0.18 case per million population) were included in this retrospective nationwide study involving all French laboratories who perform the search of F/P fusion gene (study period: 2003-2019). The main organs involved included the spleen (44%), skin (32%), lungs (30%), heart (19%) and central nervous system (9%). Serum vitamin B12 and tryptase levels were elevated in 74/79 (94%) and 45/57 (79%) patients, respectively, and none of the 31 patients initially treated with corticosteroids achieved complete hematologic remission. All 148 (98%) IM-treated patients achieved complete hematologic and molecular (when tested, n = 84) responses. Forty-six patients eventually discontinued IM, among whom 20 (57%) relapsed. In multivariate analysis, time to IM initiation (continuous HR: 1,01 [0.99-1,03]; P = .05) and duration of IM treatment (continuous HR: 0,97 [0,95-0,99]; P = .004) were independent factors of relapse after discontinuation of IM. After a mean follow-up of 80 (56) months, the 1, 5- and 10-year overall survival rates in IM-treated patients were 99%, 95% and 84% respectively. In F/P+ MN-eo, prompt initiation of IM and longer treatment durations may prevent relapses after discontinuation of IM. 相似文献
973.
Maro Ohanian Philippe Telouk Steven Kornblau Francis Albarede Peter Ruvolo Rebecca S. S. Tidwell Adriana Plesa Rashmi Kanagal-Shamanna Eva-Laure Matera Jorge Cortes Arch Carson Charles Dumontet 《American journal of hematology》2020,95(4):422-434
Despite abundant epidemiological data linking metals to leukemia and other cancers, baseline values of toxic and essential metals in patients with leukemia and the clinical impact of these metals remain unknown. Thus, we sought to quantify metal values in untreated patients with acute myeloid leukemia (AML) and controls and determine the impact of metal values on AML patients' survival. Serum samples from patients with untreated AML and controls at Hospices Civils de Lyon were analyzed and compared for trace metals and copper isotopic abundance ratios with inductively coupled plasma mass spectrometry. Survival analysis was performed as a function of metal values, and a multi-metal score was developed for patients with AML. Serum samples were collected from 67 patients with untreated AML and 94 controls. Most patients had intermediate-risk cytogenetics (63.1%) without FLT3 internal tandem duplication mutations (75.6%) or NPM1 mutations (68.1%). Most metal values differed significantly between AML and control groups. Patients with lower magnesium and higher cadmium values had the worst survival rates, with only 36% surviving at 6 months (P = .001). The adverse prognostic effect of this combination was maintained on multivariate analysis. Based on this, we developed a novel metal score, which accounts for multiple relative abnormalities in the values of five toxic and five essential metals. Patients with a higher metal score had significantly worse survival, which was maintained on multivariate analysis (P = .03). This baseline metal scoring system was also prognostic when we applied it to a separate population of front-line AML patients. 相似文献
974.
Lelievre Benedicte Triau Stephane Codron Philippe Mariau Yoran Papin-Lefebvre Frederique Collin Alexandre Drevin Guillaume Le Roux Gael Briet Marie Boels David Letournel Franck 《Forensic Toxicology》2020,38(2):505-510
Forensic Toxicology - In developed countries, lead intoxication is decreasing in adults as sources of contamination were considerably reduced. Hence, cases of lead encephalopathy have become... 相似文献
975.
Demaria Lucie Borie Raphael Benali Khadija Piekarski Eve Goossens Julia Palazzo Elisabeth Forien Marine Dieudé Philippe Crestani Bruno Ottaviani Sébastien 《Clinical rheumatology》2020,39(9):2727-2734
Clinical Rheumatology - Bone sarcoidosis is usually rare. Imaging procedures such as fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) can reveal bone... 相似文献
976.
Nguyen Minh Vu Chuong Courtier Anaïs Adrait Annie Defendi Federica Couté Yohann Baillet Athan Guigue Lisa Gottenberg Jacques-Eric Dumestre-Pérard Chantal Brun Virginie Gaudin Philippe 《Clinical rheumatology》2020,39(9):2553-2562
Clinical Rheumatology - Rheumatoid arthritis (RA) is a debilitating disease, but patient management and treatment have been revolutionized since the advent of bDMARDs. However, about one third of... 相似文献
977.
Siriez Romain Alpan Lütfiye Elasaad Kossay Devel Philippe Laloy Julie Dogné Jean-Michel Douxfils Jonathan 《Journal of thrombosis and thrombolysis》2020,49(3):395-403
Journal of Thrombosis and Thrombolysis - Although DOACs do not require regular measurements of their blood concentrations, clinical situations may require an assessment of their concentration.... 相似文献
978.
Vallet Nicolas Ertault Marjan Delaye Jean-Baptiste Chalopin Thomas Villate Alban Drieu La Rochelle Laurianne Lejeune Julien Foucault Amlie Eloit Martin Barin-Le Guellec Chantal Hrault Olivier Colombat Philippe Gyan Emmanuel 《Annals of hematology》2020,99(2):229-239
Annals of Hematology - The prognostic significance of hypercalcemia in lymphoma has only been studied on small series to date. We conducted a retrospective, monocentric, matched-control study that... 相似文献
979.
980.
Isabelle Rouleau Gaston De Serres Danuta M. Skowronski Jean Philippe Drolet Chantal Lemire Eveline Toth Monique Landry 《Vaccine》2014