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941.
Bossi P Tegnell A Baka A Van Loock F Hendriks J Werner A Maidhof H Gouvras G;Task Force on biological Chemial Agent Threats Public Health Directorate European Commission Luxembourg 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2004,9(12):E21-E22
Most of the viruses involved in causing encephalitis are arthropod-borne viruses, with the exception of arenaviruses that are rodent-borne. Even if little information is available, there are indications that, most of these encephalitis-associated viruses could be used by aerosolisation during a bioterrorist attack. Viral transfer from blood to the CNS through the olfactory tract has been suggested. Another possible route of contamination is by vector-borne transmission such as infected mosquitoes or ticks. Alphaviruses are the most likely candidates for weaponisation. The clinical course of the diseases caused by these viruses is usually not specific, but differentiation is possible by using an adequate diagnostic tool. There is no effective drug therapy for the treatment of these diseases and treatment is mainly supportive, but vaccines protecting against some of these viruses do exist. 相似文献
942.
Alpha-fetoprotein,the major fetal serum protein,is not essential for embryonic development but is required for female fertility 总被引:6,自引:0,他引:6
Gabant P Forrester L Nichols J Van Reeth T De Mees C Pajack B Watt A Smitz J Alexandre H Szpirer C Szpirer J 《Proceedings of the National Academy of Sciences of the United States of America》2002,99(20):12865-12870
The alpha-fetoprotein gene (Afp) is a member of a multigenic family that comprises the related genes encoding albumin, alpha-albumin, and vitamin D binding protein. The biological role of this major embryonic serum protein is unknown although numerous speculations have been made. We have used gene targeting to show that AFP is not required for embryonic development. AFP null embryos develop normally, and individually transplanted homozygous embryos can develop in an AFP-deficient microenvironment. Whereas mutant homozygous adult males are viable and fertile, AFP null females are infertile. Our analyses of these mice indicate that the defect is caused by a dysfunction of the hypothalamic/pituitary system, leading to anovulation. 相似文献
943.
Yves Louvard MD Martyn Thomas MD Vladimir Dzavik MD David Hildick‐Smith MD Alfredo R. Galassi MD Manuel Pan MD Francisco Burzotta MD Michael Zelizko MD Darius Dudek MD Peter Ludman MD Imad Sheiban MD Jens F. Lassen MD Olivier Darremont MD Adnan Kastrati MD Josef Ludwig MD Ioannis Iakovou MD Philippe Brunel MD Alexandra Lansky MD David Meerkin MD Victor Legrand MD Alfonso Medina MD Thierry Lefèvre MD 《Catheterization and cardiovascular interventions》2008,71(2):175-183
944.
Philippe G. Jorens Peter P. Michielsen Paul A. Pelckmans Johan Fevery Valeer J. Desmet Andr P. Geubel Jacques Rahier Yvan M. Van Maercke 《Liver international》1992,12(6):381-386
ABSTRACT— We report the case of a 35-year-old man who contracted vitamin A-induced liver cirrhosis. Five years before, he had been investigated for vitamin A-induced non-cirrhotic portal hypertension. In this case, the clinical and histopathologic evolution from non-cirrhotic portal hypertension to cirrhosis was documented. In spite of the cessation of pharmaceutical vitamin A intake, the disease progressed. Therapy with colchicine and phenobarbital apparently did not influence evolution to cirrhosis. This suggests that vitamin A can trigger largely unknown mechanisms of liver fibrosis which seem to be self-perpetuating. 相似文献
945.
M.D.Jean Marc Durand M.D.Patrice Lef vre M.D.Philippe Hovette M.D.Soumana Issifi M.D.Maurice Mongin 《The American journal of medicine》1991,90(6):675-677
PURPOSE: The purpose of this study was to determine the effect of dapsone on platelet count in patients with human immunodeficiency virus (HIV)-related autoimmune thrombocytopenia. PATIENTS AND METHODS: Eleven patients with HIV-related thrombocytopenia received dapsone (50 to 125 mg/day) for 2 to 43 months. Patients with the acquired immunodeficiency syndrome were not enrolled. RESULTS: Of the 11 patients, six developed platelet counts above 50 X 10(9)/L and did not require any other specific therapy. No significant side effects were observed. CONCLUSION: We conclude that dapsone may be effective in some patients with HIV-related thrombocytopenia. 相似文献
946.
947.
Karine Vidal Denis Breuillé Patrick Serrant Philippe Denis Françoise Glomot Fabienne Béchereau Isabelle Papet 《European journal of nutrition》2014,53(3):963-971
Purpose
Healthy ageing is associated with higher levels of glutathione. The study aimed to determine whether long-term dietary fortification with cysteine increases cysteine and glutathione pools, thus alleviating age-associated low-grade inflammation and resulting in global physiological benefits.Methods
The effect of a 14-week dietary fortification with cysteine was studied in non-inflamed (NI, healthy at baseline) and in spontaneously age-related low-grade inflamed (LGI, prefrail at baseline) 21-month-old rats. Fifty-seven NI rats and 14 LGI rats received cysteine-supplemented diet (4.0 g/kg of free cysteine added to the standard diet containing 2.8 g/kg cysteine). Fifty-six NI rats and 16 LGI rats received a control alanine-supplemented diet.Results
Cysteine fortification in NI rats increased free cysteine (P < 0.0001) and glutathione (P < 0.03) in the liver and the small intestine. In LGI rats, cysteine fortification increased total non-protein cysteine (P < 0.0007) and free cysteine (P < 0.03) in plasma, and free cysteine (P < 0.02) and glutathione (P < 0.01) in liver. Food intake decreased over time in alanine-fed rats (r 2 = 0.73, P = 0.0002), whereas it was constant in cysteine-fed rats (r 2 = 0.02, P = 0.68). Cysteine fortification did not affect inflammatory markers, mortality, body weight loss, or tissue masses.Conclusion
Doubling the dietary intake of cysteine in old rats increased cysteine and glutathione pools in selected tissues. Additionally, it alleviated the age-related decline in food intake. Further validation of these effects in the elderly population suffering from age-related anorexia would suggest a useful therapeutic approach to the problem. 相似文献948.
Christine Lasset Julie Kalecinski Véronique Régnier Giovanna Barone Yann Leocmach Philippe Vanhems Franck Chauvin Delphine Lutringer-Magnin 《International journal of public health》2014,59(3):519-528
Objectives
To use both quantitative and qualitative methods to investigate the evolution of practices and opinions regarding human papillomavirus (HPV) vaccination among French general practitioners.Methods
A cross-sectional study (self-questionnaires) was performed in 2007 and repeated in 2010 among 271 general practitioners. Semi-structured interviews were conducted on 27 voluntary participants by a sociologist and analyzed according to content analysis.Results
Acceptability of HPV vaccination had increased from 2007 to 2010 (79.9 vs. 87.1 %, respectively), just as the practice of HPV vaccination among 14-year-old girls (19.0 vs. 49.1 %, respectively). Though about 60 % reported complications associated with HPV vaccination, irrespective of year, the types of difficulties have varied: difficulties related to “questions asked by patients” had decreased, though concerns about side effects had remained stable. During interviews, difficulties related to “the reason for medical consultation” and “the target age” were often associated with addressing the issue of sexuality, especially when the parents were present.Conclusions
Although the high level of acceptability of HPV vaccination among general practitioners, which increased from 2007 to 2010, there remain difficulties in addressing this practice. 相似文献949.
Philippe Schucht Sonja Knittel Johannes Slotboom Kathleen Seidel Michael Murek Astrid Jilch Andreas Raabe Jürgen Beck 《Acta neurochirurgica》2014,156(2):305-312
Background
The technique of 5-aminolevulinic acid (5-ALA) tumor fluorescence is increasingly used to improve visualization of tumor tissue and thereby to increase the rate of patients with gross total resections. In this study, we measured the resection volumes in patients who underwent 5-ALA-guided surgery for non-eloquent glioblastoma and compared them with the preoperative tumor volume.Methods
We selected 13 patients who had received a complete resection according to intraoperative 5-ALA induced fluorescence and CRET according to post-operative T1 contrast-enhanced MRI. The volumes of pre-operative contrast enhancing tissue, post-operative resection cavity and resected tissue were determined through shift-corrected volumetric analysis.Results
The mean resection cavity (29 cm3) was marginally smaller than the pre-operative contrast-enhancing tumor (39 cm3, p?=?0.32). However, the mean overall resection volume (84 cm3) was significantly larger than the pre-operative contrast-enhancing tumor (39 cm3, p?=?0.0087). This yields a mean volume of resected 5-ALA positive, but radiological non-enhancing tissue of 45 cm3. The mean calculated rim of resected tissue surpassed pre-operative tumor diameter by 6 mm (range 0–10 mm).Conclusions
Results of the current study imply that (i) the resection cavity underestimates the volume of resected tissue and (ii) 5-ALA complete resections go significantly beyond the volume of pre-operative contrast-enhancing tumor bulk on MRI, indicating that 5-ALA also stains MRI non-enhancing tumor tissue. Use of 5-ALA may thus enable extension of coalescent tumor resection beyond radiologically evident tumor. The impact of this more extended resection method on time to progression and overall survival has not been determined, and potentially puts adjacent and functionally intact tissue at risk. 相似文献950.
Fulgence Kassi Anthony Dohan Philippe Soyer Eric Vicaut Mourad Boudiaf Patrice Valleur Marc Pocard 《American journal of surgery》2014