音乐疗法在肿瘤临床的应用

目的：观察音乐疗法在肿瘤临床中的作用。方法：采用音乐疗法配合抗肿瘤治疗。观察了128例肿瘤患者。结果：治疗组心理测试（SDS,SAS,MMPI,HAMD）及免疫指标（T－C亚群,NK－C活性）均优于对照组（P＜0．05）。结论：说明音乐疗法能调节肿瘤患者情绪,优化情感效应,改善躯体症状,增强免疫功能。高动体内积极因素,提高机体的自我调解力。     

医学生主观幸福感与归因方式、气质类型的关系

目的了解医学生主观幸福感状况,探讨归因方式、气质类型与主观幸福感之间关系。方法采用总体幸福感量表、多维-多向归因量表和气质类型自评量表对医学院临床医学专业、麻醉专业和护理专业的190名学生进行调查。调查结果采用t检验、方差分析、相关分析、回归分析等方法进行统计分析。结果①不同专业之间主观幸福感差异显著(F=6.02,P0.01);②内控型被试的主观幸福感显著高于外控型被试(t=3.07,P0.01);③主观幸福感得分与多血质呈显著负相关(r=-0.17,P0.05),与抑郁质呈显著正相关(r=0.16,P0.05)。结论归因方式和气质类型对医学生主观幸福感有一定的预测作用,是影响医学生主观幸福感的两个重要因素。     

糖皮质激素联合 GnRH-α 在轻度子宫内膜异位症合并复发性早期流产患者中的疗效评价 #br#

近年来,子宫动脉栓塞术（uterine arterial embolization,UAE）用于治疗子宫腺肌病（adenomyosis,AD）已取得较好的临床效果[1-4]。子宫动脉的发育情况虽然在传统妇产科治疗中无特殊意义,但对UAE的成功及栓塞后临床疗效可能起着一定的作用[5]。本研究将6例一侧子宫动脉缺如或发育不良的子宫腺肌病患者子宫动脉栓塞术后的临床疗效分析报道如下。     

米非司酮对早孕后期蜕膜及绒毛孕激素受体及细胞凋亡的影响

目的　探讨米非司酮对早孕后期蜕膜及绒毛孕激素受体 (PR)及细胞凋亡的影响。方法　取孕 7～12周人工流产 (对照组 )、顿服米非司酮 2 0 0mg后 2 4h流产及服药 4 8h后流产各 2 0例患者的蜕膜及绒毛 ,应用免疫组织化学方法 (ABC法 )测定PR含量 ;应用脱氧核糖核酸末端转移酶介导的缺口末端标记法测定比较细胞凋亡比率。结果　蜕膜组织PRH 积分对照组为 170 .33± 4 5 .71,服药 2 4h组为 16 3.5 5± 2 7.36 ,服药 4 8h组为 2 0 5 .2 9±34.0 4 ,后二组与对照组比较有显著性差异。对照组绒毛组织PR全部为阴性 ,服药 2 4h组 1例弱阳性 ,服药 4 8h组3例阳性 ;蜕膜细胞凋亡率对照组为 (0 .2 0 6± 0 .175 ) ,服药 2 4h组为 (0 .2 35± 0 .189) ,服药 4 8h组为 (0 .391± 0 .2 0 3) ,后者与对照组比较有显著性差异。绒毛细胞凋亡率对照组为 (0 .0 5 2± 0 .0 34) ,服药 2 4h组为 (0 .0 94± 0 .110 ) ,服药 4 8h组为 (0 .10 2± 0 .12 5 ) ,三组间差异无统计学意义。结论　米非司酮可以使蜕膜及绒毛中PR及细胞凋亡率升高 ,服药 4 8h比 2 4h作用更显著 ,其流产机制也可能作用于绒毛。     

冠心病介入治疗的舒适护理

目的观察舒适护理模式对冠心病介入治疗后患者不适症状及并发症的影响。方法将120例行冠心病介入治疗患者随机分为实验组和对照组,每组各60例,对照组采用两条弹性绷带交叉粘贴包扎股动脉,术后实行常规平卧位卧床24h,术侧下肢制动12h,给予一般常规护理。实验组采用改良弹力绷带包扎法,即在对照组的基础上增加第三条弹性绷带包扎,第三条弹力绷带在两条绷带的交叉点上横跨粘贴包扎,术后3h后,即可在床上平行移动身体,在保持术侧肢体伸直的前提下,用软枕帮助患者术侧侧卧,与平卧位交替,并做好心理护理。结果对两组患者舒适情况比较(包括焦虑、烦躁、排尿困难、腰酸背痛、失眠),差异有统计学意义,(均p<0.05)。结论舒适护理缩短患者绝对卧床和术侧肢体制动的时间,减少了术后不适和并发症,增加患者舒适度。     

黄芪联合依那普利治疗早期糖尿病肾病40例疗效观察

目的：观察黄芪联合依那普利治疗早期糖尿病肾病的临床疗效。方法：120例病例随机分为3组，每组40例。黄芪组采用黄芪注射液治疗，依那普利组采用依那普利治疗，黄芪联合依那普利组（黄联依组）采用黄芪注射液和依那普利治疗。结果：黄联依组治疗后24h尿蛋白排泄率、β2微球蛋白较黄芪组和依那普利组治疗后明显降低（P〈0．05，P〈0．01）。结论：中西医结合治疗早期糖尿病肾病疗效显著，值得在临床上推广应用。     

Low-grade albuminuria is associated with poor memory performance in the nondemented Chinese elderly with type 2 diabetes

Metabolic Brain Disease - Recent studies have correlated cognitive function with albuminuria. We investigated the association between low-grade albuminuria and cognitive performance in nondemented...     

Altered expression of FANCL confers mitomycin C sensitivity in Calu-6 lung cancer cells

Fanconi anemia (FA) results from mutations in a group of genes whose products, including BRCA2 and BACH1/BRIP1, are known to function in one common pathway (the FA-BRCA pathway) to guard genome integrity, especially when challenged by DNA crosslinking agents, such as Cisplatin and mitomycin C (MMC). The extremely high incidence of cancer in FA patients reveals the essentialness of this pathway in tumor suppression. However, this pathway's involvement in nonFA cancers is not well understood. To evaluate the contribution of the FA-BRCA pathway to cancer, we investigated the integrity of the FA-BRCA pathway in ten human cancer cell lines. We found that the Calu-6 lung cancer cell line carries a defective FA-BRCA pathway. In this cell line, the examination of six FA proteins, essential for the activation of the FA-BRCA pathway, detected substantially reduced expression of FANCL, a catalytic subunit of the ubiquitin ligase/E3-complex. Reconstitution of FANCL in these cells restored the activation of the FA-BRCA pathway, but MMC sensitivity of the cells with a complemented FA-BRCA pathway was decreased as compared to the cells with an impaired FA-BRCA pathway. Collectively, the abnormal FANCL expression is the cause leading to a defective FA-BRCA pathway, which confers the sensitivity of Calu-6 cells to MMC. This suggests that the correlation of an intact FA-BRCA pathway with MMC resistance may emerge as a common mechanism underlying resistance to DNA crosslinking agents in cancer patients.     

四物汤化裁治疗肺癌咯血

四物汤是传统的理血之剂,我们在治疗肺癌咯血,遇到西药止血药无效时,应用本方常能奏效,且作用较为持久。本文将肺癌咯血按中医辨证分为四型,即:肺热咯血、瘀血咯血、阴虚咯血、血虚咯血,每型均用四物汤酌加三味理血药,常收到较理想的止血效果,文中每型均举有典型病例。