Global,Regional, and National Estimates of Nutritional Deficiency Burden among Reproductive Women from 2010 to 2019

Women of reproductive age (15–49 years) are often considered a vulnerable population affected by nutritional deficiencies, impairing their health and that of their offspring. We briefly introduced (a) the incidence and disability-adjusted life years (DALYs) trends from 2010 to 2019 and (b) the correlation between sex differences and income levels and nutritional deficiencies of reproductive women firstly. Notably, the burden of overall nutritional deficiencies among reproductive women remained generally stable from 2010 to 2019, whereas the iodine and vitamin A deficiencies as a subcategory were associated with increased incidence rates and DALYs, respectively. A significant increasing trend occurred in South Asia, Southeast Asia, and Turkey for incidence, and Western Sub-Saharan Africa and Zimbabwe had a strong increase for DALYs. Further analysis of the correlation between nutritional deficiency incidence and economic capacity showed that they were not correlated with the income of women themselves, as was the result of income difference with men. The results of this study will help to identify gaps in nutritional deficiency burden among reproductive women and facilitate the development of regional or national responses. Compared with economic capital, macroscopic political guarantees and social and cultural capital are important measures to remedy the nutritional deficiencies of reproductive women.     

Densovirus Oil Suspension Significantly Improves the Efficacy and Duration of Larvicidal Activity against Aedes albopictus

Aedes albopictus is the sole vector for various mosquito-borne viruses, including dengue, chikungunya, and Zika. Ecofriendly biological agents are required to reduce the spread of these mosquito-borne infections. Mosquito densoviruses (MDVs) are entomopathogenic mosquito-specific viruses, which can reduce the capacity of isolated vectors and decrease mosquito-borne viral disease transmission. However, their variable pathogenicity restricts their commercial use. In the present study, we developed a series of novel larvicide oil suspensions (denoted Bacillus thuringiensis (Bti) oil, Ae. albopictus densovirus (AalDV-5) oil, and a mixture of AalDV-5+Bti oil), which were tested against Ae. albopictus larvae under experimental semi-field and open-field conditions. The effect of AalDV-5 on non-target species was also evaluated. The combined effect of AalDV-5+Bti was greater than that of individual toxins and was longer lasting and more persistent compared with the laboratory AalDV-5 virus strain. The virus was quantified on a weekly basis by quantitative polymerase chain reaction (qPCR) and was persistently detected in rearing water as well as in dead larvae. Wildtype densovirus is not pathogenic to non-target organisms. The present findings confirm the improved effect of a mixed microbial suspension (AalDV-5+Bti oil) larvicide against Ae. albopictus. The development and testing of these products will enable better control of the vector mosquitoes.     

血清瘦素水平与抑郁症的相关性研究

〔摘 要〕 目的：探讨抑郁症患者血清瘦素水平变化的临床意义。 方法：选取 2020 年 1 月至 2020 年 12 月山东省戴庄医 院收治的 60 例抑郁症患者和募集的 30 例健康志愿者为研究对象,抑郁症患者依照病情予常规口服抗抑郁药物治疗 4 周, 采用汉密尔顿抑郁量表（HAMD）评估患者治疗前后抑郁症状的严重程度,采用酶联免疫吸附测定法（ELISA）测定健 康志愿者和抑郁症患者治疗前后的血清瘦素水平,分析抑郁症患者血清瘦素水平的变化。 结果：（1）抑郁症患者治疗后 的 HAMD 评分较抑郁症患者治疗前下降,治疗总有效率为 100.00 %;（2）抑郁症患者治疗前的瘦素水平显著高于健康 志愿者,且口服抗抑郁药物治疗后的瘦素水平显著高于治疗前,差异均具有统计学意义（P ＜ 0.01）;（3）不同性别之 间的瘦素水平比较,女性瘦素水平均高于相同组别和时间的男性瘦素水平,差异均具有统计学意义（P ＜ 0.01）。 结论：（1）抑郁症患者的血清瘦素水平高于健康人群,且经口服抗抑郁治疗后血清瘦素水平进一步升高。（2）健康人群及抑郁 症患者中女性的血清瘦素水平均高于相应状态下男性的血清瘦素水平。     

音乐疗法在肿瘤临床的应用

目的：观察音乐疗法在肿瘤临床中的作用。方法：采用音乐疗法配合抗肿瘤治疗。观察了128例肿瘤患者。结果：治疗组心理测试（SDS,SAS,MMPI,HAMD）及免疫指标（T－C亚群,NK－C活性）均优于对照组（P＜0．05）。结论：说明音乐疗法能调节肿瘤患者情绪,优化情感效应,改善躯体症状,增强免疫功能。高动体内积极因素,提高机体的自我调解力。     

血清25羟维生素D3缺乏与 2型糖尿病微血管并发症的相关性研究

目的 探讨血清25羟维生素D3[25(OH)D3]与2型糖尿病微血管病变(DMAP)的关系.方法 评估812例2型糖尿病患者的DMAP情况,包括糖尿病神经病变、糖尿病视网膜病变及糖尿病肾病,其中无DMAP 371例、单一DMAP 296例、复合DMAP 145例.采用电化学发光法测定血清25(OH)D3水平,并记录病程、血压、计算体质量指数,测定糖化血红蛋白、血脂、尿肌酐比值等指标.采用多元有序Logistic回归分析数据.结果 纳入的2型糖尿病患者中,67.5％维生素D缺乏,24.8％维生素D不足.单一DMAP组25(OH)D3水平[(16.95±6.97)ng/mL]及复合DMAP组25(OH)D3水平[(16.23±8.28)ng/mL]均显著低于无DMAP组[(19.41±8.13)ng/mL],差别均具有统计学意义(t=4.205,3.976,均P<0.01).多元有序Logistic回归分析显示,25(OH)D3与DMAP呈独立负相关(Est=-0.027,OR=0.947,95％CI:0.954～0.994,P=0.011).结论 血清25(OH)D3缺乏可能是2型糖尿病患者合并DMAP的独立危险因素,25(OH)D3水平越低越容易合并复合DMAP.     

米非司酮对早孕后期蜕膜及绒毛孕激素受体及细胞凋亡的影响

目的　探讨米非司酮对早孕后期蜕膜及绒毛孕激素受体 (PR)及细胞凋亡的影响。方法　取孕 7～12周人工流产 (对照组 )、顿服米非司酮 2 0 0mg后 2 4h流产及服药 4 8h后流产各 2 0例患者的蜕膜及绒毛 ,应用免疫组织化学方法 (ABC法 )测定PR含量 ;应用脱氧核糖核酸末端转移酶介导的缺口末端标记法测定比较细胞凋亡比率。结果　蜕膜组织PRH 积分对照组为 170 .33± 4 5 .71,服药 2 4h组为 16 3.5 5± 2 7.36 ,服药 4 8h组为 2 0 5 .2 9±34.0 4 ,后二组与对照组比较有显著性差异。对照组绒毛组织PR全部为阴性 ,服药 2 4h组 1例弱阳性 ,服药 4 8h组3例阳性 ;蜕膜细胞凋亡率对照组为 (0 .2 0 6± 0 .175 ) ,服药 2 4h组为 (0 .2 35± 0 .189) ,服药 4 8h组为 (0 .391± 0 .2 0 3) ,后者与对照组比较有显著性差异。绒毛细胞凋亡率对照组为 (0 .0 5 2± 0 .0 34) ,服药 2 4h组为 (0 .0 94± 0 .110 ) ,服药 4 8h组为 (0 .10 2± 0 .12 5 ) ,三组间差异无统计学意义。结论　米非司酮可以使蜕膜及绒毛中PR及细胞凋亡率升高 ,服药 4 8h比 2 4h作用更显著 ,其流产机制也可能作用于绒毛。     

冠心病介入治疗的舒适护理

目的观察舒适护理模式对冠心病介入治疗后患者不适症状及并发症的影响。方法将120例行冠心病介入治疗患者随机分为实验组和对照组,每组各60例,对照组采用两条弹性绷带交叉粘贴包扎股动脉,术后实行常规平卧位卧床24h,术侧下肢制动12h,给予一般常规护理。实验组采用改良弹力绷带包扎法,即在对照组的基础上增加第三条弹性绷带包扎,第三条弹力绷带在两条绷带的交叉点上横跨粘贴包扎,术后3h后,即可在床上平行移动身体,在保持术侧肢体伸直的前提下,用软枕帮助患者术侧侧卧,与平卧位交替,并做好心理护理。结果对两组患者舒适情况比较(包括焦虑、烦躁、排尿困难、腰酸背痛、失眠),差异有统计学意义,(均p<0.05)。结论舒适护理缩短患者绝对卧床和术侧肢体制动的时间,减少了术后不适和并发症,增加患者舒适度。     

黄芪联合依那普利治疗早期糖尿病肾病40例疗效观察

目的：观察黄芪联合依那普利治疗早期糖尿病肾病的临床疗效。方法：120例病例随机分为3组，每组40例。黄芪组采用黄芪注射液治疗，依那普利组采用依那普利治疗，黄芪联合依那普利组（黄联依组）采用黄芪注射液和依那普利治疗。结果：黄联依组治疗后24h尿蛋白排泄率、β2微球蛋白较黄芪组和依那普利组治疗后明显降低（P〈0．05，P〈0．01）。结论：中西医结合治疗早期糖尿病肾病疗效显著，值得在临床上推广应用。