全文获取类型
收费全文 | 350篇 |
免费 | 19篇 |
国内免费 | 16篇 |
专业分类
儿科学 | 22篇 |
妇产科学 | 7篇 |
基础医学 | 48篇 |
口腔科学 | 17篇 |
临床医学 | 33篇 |
内科学 | 52篇 |
皮肤病学 | 13篇 |
神经病学 | 8篇 |
特种医学 | 75篇 |
外科学 | 26篇 |
综合类 | 14篇 |
预防医学 | 11篇 |
眼科学 | 15篇 |
药学 | 16篇 |
中国医学 | 1篇 |
肿瘤学 | 27篇 |
出版年
2022年 | 5篇 |
2021年 | 4篇 |
2019年 | 3篇 |
2018年 | 8篇 |
2017年 | 3篇 |
2016年 | 8篇 |
2015年 | 8篇 |
2014年 | 17篇 |
2013年 | 19篇 |
2012年 | 4篇 |
2011年 | 10篇 |
2010年 | 32篇 |
2009年 | 26篇 |
2008年 | 4篇 |
2007年 | 16篇 |
2006年 | 9篇 |
2005年 | 8篇 |
2003年 | 2篇 |
2002年 | 4篇 |
2001年 | 5篇 |
2000年 | 4篇 |
1999年 | 8篇 |
1998年 | 32篇 |
1997年 | 22篇 |
1996年 | 16篇 |
1995年 | 11篇 |
1994年 | 12篇 |
1993年 | 9篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 10篇 |
1988年 | 6篇 |
1987年 | 5篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1982年 | 6篇 |
1981年 | 2篇 |
1980年 | 9篇 |
1979年 | 1篇 |
1978年 | 5篇 |
1977年 | 3篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1972年 | 1篇 |
1959年 | 1篇 |
1958年 | 2篇 |
1957年 | 1篇 |
1955年 | 1篇 |
1954年 | 2篇 |
1949年 | 2篇 |
排序方式: 共有385条查询结果,搜索用时 15 毫秒
101.
102.
103.
EL Hardaker MS Freeman N Dale P Bahra F Raza KH Banner C Poll 《British journal of pharmacology》2010,160(8):1985-1996
BACKGROUND AND PURPOSE
Acute exacerbations of chronic obstructive pulmonary disease (COPD), which are often associated with respiratory infections, are defined as a worsening of symptoms that require a change in medication. Exacerbations are characterized by a reduction in lung function, quality of life and are associated with increased pro-inflammatory mediators in the lung. Our aim was to develop an animal model to mimic aspects of this exaggerated inflammatory response by combining key etiological factors, tobacco smoke (TS) and bacterial lipopolysaccharide (LPS).EXPERIMENTAL APPROACH
Rats were exposed to TS for 30 min twice a day for 2 days. On day 3 animals were exposed to LPS for 30 min followed by exposure to TS 5 h later. Inflammation, mucus and lung function were assessed 24 h after LPS.KEY RESULTS
Neutrophils, mucus, oedema and cytotoxicity in lung and/or bronchoalveolar lavage was increased in animals exposed to combined LPS and TS, compared with either stimulus alone. Lung function was impaired in animals exposed to combined LPS and TS. Inflammatory cells, oedema and mucus were unaffected by pretreatment with the corticosteroid, budesonide, but were reduced by the phosphodiesterase 4 selective inhibitor roflumilast. Additionally, lung function was improved by roflumilast.CONCLUSIONS AND IMPLICATIONS
We have established an in vivo model mimicking characteristic features of acute exacerbations of COPD including lung function decline and increased lung inflammation. This model may be useful to investigate molecular and cellular mechanisms underlying such exacerbations, to identify new targets and to discover novel therapeutic agents. 相似文献104.
Aspergillosis (a fungal infection by an organism of the Aspergillus species) of the oral cavity is an uncommon condition which most frequently occurs in immunocompromised patients, such as those with haematological malignancies. In such patients, prolonged neutropenia secondary to chemotherapeutic agents enables the spread of invasive aspergillosis, which is unaffected by anatomical barriers. Early detection and treatment of the condition is essential to avoid more serious complications, such as disseminated infection, which results in increased morbidity and mortality. This case report describes a patient with acute myeloid leukaemia who developed localized invasive Aspergillus flavus of the palate. High‐dose antifungal therapy was instituted along with surgical removal of the involved tissues. Aspergillosis of the palate was successfully eradicated with no long‐term ill effects from the treatment. Management of invasive aspergillosis includes early aggressive antifungal medication combined with surgical removal of the involved tissues. 相似文献
105.
Aim: Most studies looking at the relation between medication use and fall among the hospitalized elderly patients, were done in Western countries. So, a study was planned to investigate the role of medications in causing falls in hospitalized Asian elderly patients.
Methods: Case note review was done for all patients age 65 years and above, who fell at least once during their hospital stay over a 12-month period. Information obtained from the case notes included: (i) demographic information; (ii) Modified Morse Fall scale; (iii) circumstances and time of fall; and (iv) medication use. From the hospital admission database, an age- and sex-matched control group was selected for comparison.
Results: Over the 12-month study period, 298 patients met the study criteria. Average age of the patients was 75.8 years, 60.4% were male and 84.9% were Chinese. Multivariate analysis showed that fallers had longer lengths of stay and were more likely to have a history of falls. Fallers were also more likely to be taking hypnotics, cough preparations and anti-platelets, but less likely to be taking paracetamol. Fallers were on fewer medications.
Conclusion: Elderly hospitalized patients on hypnotic drugs, cough preparations and anti-platelets were more likely to fall. Appropriate usage of analgesics, especially paracetamol, to relieve pain may reduce falls. 相似文献
Methods: Case note review was done for all patients age 65 years and above, who fell at least once during their hospital stay over a 12-month period. Information obtained from the case notes included: (i) demographic information; (ii) Modified Morse Fall scale; (iii) circumstances and time of fall; and (iv) medication use. From the hospital admission database, an age- and sex-matched control group was selected for comparison.
Results: Over the 12-month study period, 298 patients met the study criteria. Average age of the patients was 75.8 years, 60.4% were male and 84.9% were Chinese. Multivariate analysis showed that fallers had longer lengths of stay and were more likely to have a history of falls. Fallers were also more likely to be taking hypnotics, cough preparations and anti-platelets, but less likely to be taking paracetamol. Fallers were on fewer medications.
Conclusion: Elderly hospitalized patients on hypnotic drugs, cough preparations and anti-platelets were more likely to fall. Appropriate usage of analgesics, especially paracetamol, to relieve pain may reduce falls. 相似文献
106.
107.
108.
Effects of inhaled corticosteroid on bone turnover in children with bronchial asthma 总被引:9,自引:0,他引:9
Long-term usage of systemic steroids is associated with multiple side effects. One of the major morbidities is due to its effect on bone metabolism leading to bone loss and resulting in skeletal fractures. This study was conducted to determine the effects of inhaled steroids on bone mineral density (BMD) and biochemical bone markers. Twenty-four children with frequent episodic or mild persistent asthma who satisfied the clinical criteria for starting on inhaled corticosteroids (ICS) were enrolled into the study. The BMD scan was done using dual energy X-ray absorptiometry, prior to starting ICS therapy and 6 months later. Biochemical markers of bone metabolism, (i) serum osteocalcin as a bone formation marker, and (ii) urinary deoxypyridinoline (Upd) as a bone resorption marker, were taken prior to ICS treatment and at 2 monthly intervals. The biochemical markers were all taken in the morning. Twenty-four, age- and sex-matched children with mild episodic asthma, not requiring ICS, were used as controls for the BMD measurements. The BMD scan was done upon enrollment into the study and 6 months later. Twenty-four children on ICS and 24 controls completed the study. The subjects were on a mean dose of beclomethasone dipropionate (BDP) 0.4 mg/day. One subject needed a short course of Prednisolone in the early treatment period. None of the controls needed oral steroid therapy. One child in the control group sustained a greenstick fracture after an accidental fall. The mean rate of change of BMD was 1.8% +/- 12.3 in the subjects on BDP. This was lower than the 6.1% +/- 10.6 among the control subjects. However, this difference did not reach statistical significance (P = 0.16). There was a significant increase in serum osteocalcin level after 6 months of BDP treatment from 66.83 +/- 22.71 ng/mL to 81.61 +/- 24.66 ng/mL (P < 0.005). There was a decline in Upd from 36.2 +/- 47.1 nmol/mmol creatinine to 21.4 +/- 6.92 nmol/mmol creatinine. However, this did not reach statistical significance. There was no difference in the statural gain between the subjects on ICS and their controls. This study showed that 6 months of ICS therapy (mean dose 0.4 mg/day) had no significant adverse effect on bone metabolism in asthmatic children. 相似文献
109.
110.
Amanda?J?DaleyEmail author Robert?J?Copeland Neil?P?Wright Jerry?KH?Wales 《BMC public health》2005,5(1):113