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Measuring health care workers’ perceptions of what constitutes a compassionate organisation culture and working environment: Findings from a quantitative feasibility survey 下载免费PDF全文
Robert McSherry PhD RGN DipN B.Sc. MSc PGCE RT FHEC FFNRRCSI NTF Paddy Pearce RGN B.Sc. MSc 《Journal of nursing management》2018,26(2):127-139
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Honorio T. Benzon MD Meghan E. Rodes MD Kiran Chekka MD Khalid Malik MD William H. Pearce MD 《Pain practice》2012,12(1):66-70
Abstract: Scalene muscle injections are used to confirm the diagnosis of neurogenic thoracic outlet syndrome and predict the response of patients to surgery. We performed a retrospective study to determine if relief of pain was related to brachial plexus blockade in these patients. Methods: We reviewed the charts of 12 patients who had anterior and middle scalene muscle injections, for neurogenic thoracic outlet syndrome, between April 2009 and September 2010. The injections were performed under ultrasound guidance wherein 2 to 5 mL of 0.25% bupivacaine was injected into the belly of the anterior and scalene muscles. The following were noted: (1) sites of preprocedure pain; (2) volume injected into each of the anterior and middle scalene muscles; (3) presence of numbness after injection; and (4) presence and duration of pain relief. Results: All 12 patients had relief of their pain. Six of the twelve patients developed numbness, which ranged from blockade of the C4‐5, C6‐7, and C4‐T1 dermatomes. In the patients who developed numbness, there was no relationship between the duration of numbness and the duration of pain relief or the location of numbness and the location of pain relief. Conclusions: The relief from scalene muscle injections in patients with neurogenic thoracic outlet syndrome is not related to blockade of the brachial plexus. ? 相似文献
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David O. McDonald Simon H. S. Pearce 《Journal of molecular medicine (Berlin, Germany)》2009,87(10):971-980
Thyroid peroxidase (TPO) is the key enzyme in thyroid hormone production and a universal autoantigen in Graves’ and other
autoimmune thyroid diseases. We wished to explore the expression of TPO and whether it was affected by thionamide antithyroid
drugs. We studied recombinant TPO, stably expressed by a Chinese hamster ovary cell line (CHO-TPO) and transiently expressed
TPO-enhanced green fluorescent protein (eGFP) and -FLAG fusion proteins. Immunoblotting of CHO-TPO cell extracts showed high-molecular
weight (HMW) TPO isoforms that were resistant to reduction, as well as 110 kDa monomeric TPO. Co-immunoprecipitation and enzyme-linked-immunosorbent
assay (ELISA) binding studies of FLAG- and eGFP-tagged TPO demonstrated TPO dimerisation. CHO-TPO cells cultured in methimazole
(MMI) for 10 days showed a significant reduction in HMW-TPO isoforms at MMI concentrations of 1 μM and above (p < 0.01), whereas monomeric TPO expression was unchanged. We observed a similar reduction in HMW-TPO in CHO-TPO cells cultured
in propylthiouracil (10 μM and above). Binding of Graves’ disease patient sera and TPO-Fabs to enzymatically active TPO that
was captured onto solid phase was not abrogated by MMI. The cellular localisation of TPO in CHO-TPO cells was unchanged by
MMI treatment. Our demonstration of homodimeric TPO and the reduction in HMW-TPO isoforms during thionamide treatment of CHO-TPO
cells shows, for the first time, an effect of thionamides on TPO structure. This suggests a structural correlate to the effect
of thionamides on TPO enzymatic activity and opens up a novel potential mechanism for thionamide immunomodulation of autoimmune
thyroid disease. 相似文献