全文获取类型
收费全文 | 755篇 |
免费 | 30篇 |
国内免费 | 14篇 |
专业分类
儿科学 | 46篇 |
妇产科学 | 7篇 |
基础医学 | 68篇 |
口腔科学 | 17篇 |
临床医学 | 112篇 |
内科学 | 108篇 |
皮肤病学 | 9篇 |
神经病学 | 20篇 |
特种医学 | 200篇 |
外科学 | 91篇 |
综合类 | 33篇 |
预防医学 | 6篇 |
眼科学 | 26篇 |
药学 | 45篇 |
肿瘤学 | 11篇 |
出版年
2022年 | 3篇 |
2021年 | 3篇 |
2020年 | 3篇 |
2019年 | 3篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 6篇 |
2015年 | 6篇 |
2014年 | 17篇 |
2013年 | 14篇 |
2012年 | 7篇 |
2011年 | 25篇 |
2010年 | 20篇 |
2009年 | 24篇 |
2008年 | 8篇 |
2007年 | 24篇 |
2006年 | 14篇 |
2005年 | 13篇 |
2004年 | 8篇 |
2003年 | 14篇 |
2002年 | 12篇 |
2001年 | 14篇 |
2000年 | 3篇 |
1999年 | 23篇 |
1998年 | 42篇 |
1997年 | 48篇 |
1996年 | 38篇 |
1995年 | 39篇 |
1994年 | 24篇 |
1993年 | 26篇 |
1992年 | 15篇 |
1991年 | 19篇 |
1990年 | 19篇 |
1989年 | 13篇 |
1988年 | 24篇 |
1987年 | 24篇 |
1986年 | 23篇 |
1985年 | 22篇 |
1984年 | 9篇 |
1983年 | 10篇 |
1982年 | 20篇 |
1981年 | 12篇 |
1980年 | 26篇 |
1979年 | 5篇 |
1978年 | 13篇 |
1977年 | 25篇 |
1976年 | 13篇 |
1975年 | 8篇 |
1972年 | 2篇 |
1963年 | 2篇 |
排序方式: 共有799条查询结果,搜索用时 265 毫秒
31.
Mouraviev VB Pautler SE Hayman WP 《Scandinavian journal of urology and nephrology》2002,36(4):317-318
To date, there have been no reports of Fournier's gangrene following penile self-injection of cocaine. We report a case of cocaine-induced Fournier's gangrene requiring parenteral antibiotics followed by primary surgical debridement and delayed reconstructive procedure of penile skin. 相似文献
32.
The diagnostic rate of small, "incidental" tumors which are amenable to local excision or ablation has increased significantly due to widespread use of non-invasive body imaging tests. The role of nephron-sparing tumor-ablative surgery has expanded beyond the traditional circumstances of neoplasms in solitary/functionally solitary kidneys or tumors present bilaterally. Due to technologic advances, possible therapeutic options now include open surgery, laparoscopic, percutaneous and extraciorporeal approaches, in addition to surveillance in some cases. This review will concentrate on the new energy sources available for tumor ablation rather than the different surgical approaches, with a detailed review of renal cryoablation, radiofrequency and high intensity focused ultrasound. The emphasis is on the experimental data and the limited clinical data available to date, and challenges and current limitations of the various modalities. 相似文献
33.
Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases 总被引:1,自引:0,他引:1
J M F G Aerts C E M Hollak M van Breemen M Maas J E M Groener RG Boot 《Acta paediatrica (Oslo, Norway : 1992)》2005,94(S447):43-46
The value of biomarkers in the clinical management of lysosomal storage diseases is best illustrated by the present use of plasma chitotriosidase levels in the diagnosis and monitoring of Gaucher disease. The enzyme chitotriosidase is specifically produced and secreted by the pathological storage macrophages (Gaucher cells). Plasma chitotriosidase levels are elevated on average 1000-fold in symptomatic patients with Gaucher disease and reflect the body burden on storage cells. Changes in plasma chitotriosidase reflect changes in clinical symptoms. Monitoring of plasma chitotriosidase levels is nowadays commonly used in decision making regarding initiation and optimization of costly therapeutic interventions (enzyme replacement therapy or substrate reduction therapy). A novel substrate has been developed that further facilitates the measurement of chitotriosidase in plasma samples. Moreover, an alternative Gaucher-cell marker, CCL18, has been very recently identified and can also be employed to monitor the disease, particularly in those patients lacking chitotriosidase due to a genetic mutation. There is a need for comparable surrogate markers for other lysosomal storage diseases and the search for such molecules is an area of intense investigation.
Conclusion: The use of biomarkers can provide valuable insight into the molecular pathogenesis of LSDs, such as Gaucher disease and Fabry disease. 相似文献
Conclusion: The use of biomarkers can provide valuable insight into the molecular pathogenesis of LSDs, such as Gaucher disease and Fabry disease. 相似文献
34.
Antibodies to tumor necrosis factor alpha prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY- 14,643 总被引:7,自引:6,他引:7
Bojes HK; Germolec DR; Simeonova P; Bruccoleri A; Schoonhoven R; Luster MI; Thurman RG 《Carcinogenesis》1997,18(4):669-674
Several structurally dissimilar hypolipidemic drugs, plasticizers and
halogenated hydrocarbons induce peroxisomes in hepatocytes, and cause
hepatocellular adenoma and carcinoma in rats and mice. The mechanism by
which these agents act is unknown, although recent studies have suggested a
link between increased cell proliferation and hepatic cancer caused by
peroxisome proliferators. Here, we demonstrate that neutralizing antibodies
to tumor necrosis factor alpha (TNF alpha) block increases in protein
kinase C and cell proliferation due to [4-
chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,643), a
hypolipidemic drug and potent peroxisome proliferator that causes tumors.
WY-14,643 moderately elevated the level of TNF alpha mRNA in the liver. TNF
alpha was detected immunohistochemically exclusively in Kupffer cells.
These results demonstrate that WY-14,643 acts as an indirect mitogen on
hepatocytes via TNF alpha. We propose that the Kupffer cell, a major source
of TNF alpha in the liver, is involved in the mechanism of the mitogenic
effect of WY-14,643.
相似文献
35.
Evaluation of attempted prevention of unexpected infant death in very high-risk infants by planned health care 总被引:1,自引:0,他引:1
Three hundred and ninety-six babies born in Sheffield between 1982 and 1990 identified as being at "very high risk" of unexpected infant death by means of a scoring system, received an intensive programme of health care including a case discussion between a paediatrician, the GP and the health visitor held in the family doctor's surgery, weekly visits from the health visitor and informal hospital admission. Significantly fewer sudden unexpected infant deaths occurred in this group than were expected by logistic regression anlysis or occurred in the best available control group with comparable scores ( p = 0.024). Problems in evaluation include identification of an adequate control population, ethical difficulties in introducing a controlled study when the programme is already perceived as effective, and the calculation of "expected death rates". The results of this study indicate that very energetic programmes of intervention may prevent some deaths in vulnerable infants. 相似文献
36.
PJ Fielder SE Gargosky M Vaccarello K Wilson P Cohen F Diamond J Guevara-Aguirre AL Rosenbloom RG Rosenfeld 《Acta paediatrica (Oslo, Norway : 1992)》1993,82(S389):40-43
Six adult patients with growth hormone receptor deficiency (GHRD) (2 men, 4 women) with an identical defect in the growth hormone receptor (GHR) gene, were treated with recombinant human insulin-like growth factor I (IGF-I), 40 μgikg S.C. twice daily, for 7 days. Serum concentrations of IGF peptide and IGF binding protein-3 (IGFBP-3) were measured by specific radioimmunoassays; serum IGFBPs were also measured by Western ligand blotting. The size distribution of both IGF-I and IGF-II was measured in serum following size-exclusion fast-performance liquid chromatography. IGF-I treatment resulted in a normalization of serum IGF-I levels on days 1–7 of treatment and a decrease in serum IGF-II levels. The fall in IGF-II levels and the simultaneous rise in IGF-I levels, however, resulted in an unchanged total serum IGF level. The low IGFBP-3 values did not significantly change during treatment, whereas there was a slight increase in IGFBP-2 levels. Preliminary analysis of size-fractionated sera suggested an increase in IGF-I levels in the 40 and 150 kDa regions at the expense of IGF-II levels. The results suggest that despite the failure of IGF-I treatment to increase IGFBPs significantly, serum IGFBP concentrations were sufficient to maintain normal levels of IGF-I. 0 Laron syndrome, growth hormone receptor deficiency, insulin-like growth factors, insulin-like growth factor binding protein 相似文献
37.
38.
39.