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31.
Aplicación del método de Gail de cálculo de riesgo de cáncer de mama a la población valenciana 总被引:1,自引:0,他引:1
Ismael Pascual Pastor Climente María M. Morales Suárez-Varela Agustín Llopis González José F. Magraner Gil 《Clinical & translational oncology》2005,7(8):336-343
Background
The objective of this study was to verify whether the method defined by Gail is applicable and predictive in a population of women in Valencia (Spain).Population and methods
Of the 685 patients diagnosed with breast cancer and attended-to in 2000–2001, 186 incident cases were identified. The variables studied were obtained from a specific questionnaire which included characteristics of reproductive history, number of biopsies and contraceptive pill consumption prior to the diagnosis. Using the model of the National Surgical Adjuvant Breast and Bowel Project (NSABP), an adaptation of the Gail model, the risk of developing breast cancer at 5 years was estimated.Results
Only 40% of those women diagnosed as having breast cancer would have been identified as a high-risk patient by the Gail method. With our population group, the method detected the elderly women with a medical history of breast cancer who developed advanced stage disease.Conclusions
The Gail method does not adapt well to the study population of Valencia. It would be necessary to add other risk-factors to the Gail method so as to identify more patients in our area. 相似文献32.
Ángel Segura Huerta José Gómez-Codina Miguel Pastor Borgoñón Ana Yuste Izquierdo Pedro López-Tendero Regina Gironés Sarrió José A. Pérez-Fidalgo Constantino Herranz Fernández 《Clinical & translational oncology》2002,4(8):436-442
A retrospective study analyzing non-Hodgkin's lym-phoma (NHL) diagnosed in patients in our center above 65 years of age between the years 1977–1991 is reported. Histological classification has been completed following the criteria of the Working Formulation. Of 521 patients, 427 were candidates for evaluation. Those above 65 years of age comprised the subject of our study, with a total of 95 cases. Population: 43/52 male/female, 47 intermediate-grade NHL, 38 low-grade NHL, Ann Arbor stages I–II/III–IV 36/59, performance status (PS) 0-1/2-3 39/56, B symptoms yes/no 47/48, lactic dehydrogenase (LDH) normal/high 33/62, albumin normal/low 75/20, Cu normal/high 44/37 (the rest not available), B2 microglobuline normal/high 17/11 (the rest not available), tumor burden (MD Anderson) high/intermediate/low 41/28/26. The median range of cause specific survival was 30 months (50 for the low-grade NHL, 17 for the intermediate-grade). Significant prognostic factors: Histological grade (low versus high and intermediate), PS 0/1 versus 2/3, presence versus absence of B symptoms, normal versus high LDH, tumor burden (low versus high and intermediate). There is no significant statistical difference between elderly patients and young patients with a poor PS, phases I and IV, low albumin level and high and low tumor burden. Age as an adverse prognostic factor is evident in patients with a strong PS, phases II and III, normal albumin and intermediate tumor burden. The characteristics and prognostic factors of elderly patients with NHL are similar to those of the young. Age does not always function as an independent prognostic factor; age has no effect on groups with favorable or unfavorable prognostic factors and it is in the intermediate prognostic groups in which age plays a part in survival. 相似文献
33.
Rebeca Rodríguez‐Veiga Pau Montesinos Estefanía García Blanca Boluda Rafael Rojas Josefina Serrano David Martínez‐Cuadrn Carmen Martín Jaime Sanz Salvador Tabares Jos L. Piana Ignacio Lorenzo Juan Montoro Miguel Salavert Javier Pemn Isidro Jarque Pilar Solves Guillermo F. Sanz Antonio Torres Miguel A. Sanz 《Mycoses》2019,62(5):418-427
34.
H. Pau 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1959,161(1):64-70
Zusammenfassung Es wird gezeigt, daß die Körperchen bei einer bestehenden Scintillatio nivea corporis vitrei von in den Glaskörper ausgewanderten Pigmentepithelien gebildet wurden. Die doppelbrechenden Körperchen sind zunächst noch von Pigmentepithelien umgeben, die hier im Bereiche eines Melanoblastoms (-Sarkoms) durch die Netzhaut in den Glaskörper auswanderten. In pathogenetischer und morphologischer Hinsicht stimmen die Körperchen bei der Scintillatio nivea corporis vitrei mit den Drusen der Lamina vitrea weitgehend überein.Mit 7 Textabbildungen 相似文献
35.
Emilie Brard Christoph Rllig Sarah Bertoli Arnaud Pigneux Suzanne Tavitian Michael Kramer Hubert Serve Martin Bornhuser Uwe Platzbecker Carsten Müller-Tidow Claudia D. Baldus David Martínez-Cuadrn Josefina Serrano Pilar Martínez-Snchez Eduardo Rodríguez Arbolí Cristina Gil Juan Bergua Teresa Bernal Adolfo de la Fuente Burguera Eric Delabesse Audrey Bidet Pierre-Yves Dumas Pau Montesinos Christian Rcher 《Blood cancer journal》2022,12(7)
In a context of therapeutic revolution in older adults with AML, it is becoming increasingly important to select patients for the various treatment options by taking account of short-term efficacy and toxicity as well as long-term survival. Here, the data from three European registries for 1,199 AML patients aged 70 years or older treated with intensive chemotherapy were used to develop a prognostic scoring system. The median follow-up was 50.8 months. In the training set of 636 patients, age, performance status, secondary AML, leukocytosis, and cytogenetics, as well as NPM1 mutations (without FLT3-ITD), were all significantly associated with overall survival, albeit not to the same degree. These factors were used to develop a score that predicts long-term overall survival. Three risk-groups were identified: a lower, intermediate and higher-risk score with predicted 5-year overall survival (OS) probabilities of ≥12% (n = 283, 51%; median OS = 18 months), 3–12% (n = 226, 41%; median OS = 9 months) and <3% (n = 47, 8%; median OS = 3 months), respectively. This scoring system was also significantly associated with complete remission, early death and relapse-free survival; performed similarly in the external validation cohort (n = 563) and showed a lower false-positive rate than previously published scores. The European Scoring System ≥70, easy for routine calculation, predicts long-term survival in older AML patients considered for intensive chemotherapy.Subject terms: Acute myeloid leukaemia, Risk factors 相似文献
36.
Jing Ma Adrien Guillot Zhihong Yang Bryan Mackowiak Seonghwan Hwang Ogyi Park Brandon J. Peiffer Ali Reza Ahmadi Luma Melo Praveen Kusumanchi Nazmul Huda Romil Saxena Yong He Yukun Guan Dechun Feng Pau Sancho-Bru Mengwei Zang Andrew MacGregor Cameron Ramon Bataller Frank Tacke Zhaoli Sun Suthat Liangpunsakul Bin Gao 《The Journal of clinical investigation》2022,132(14)
Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH) pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH remains obscure. This translational study aims to describe the patterns of intrahepatic neutrophil infiltration and its involvement in SAH pathogenesis. Immunohistochemistry analyses of explanted livers identified two SAH phenotypes despite a similar clinical presentation, one with high intrahepatic neutrophils (Neuhi), but low levels of CD8+ T cells, and vice versa. RNA-Seq analyses demonstrated that neutrophil cytosolic factor 1 (NCF1), a key factor in controlling neutrophilic ROS production, was upregulated and correlated with hepatic inflammation and disease progression. To study specifically the mechanisms related to Neuhi in AH patients and liver injury, we used the mouse model of chronic-plus-binge ethanol feeding and found that myeloid-specific deletion of the Ncf1 gene abolished ethanol-induced hepatic inflammation and steatosis. RNA-Seq analysis and the data from experimental models revealed that neutrophilic NCF1-dependent ROS promoted alcoholic hepatitis (AH) by inhibiting AMP-activated protein kinase (a key regulator of lipid metabolism) and microRNA-223 (a key antiinflammatory and antifibrotic microRNA). In conclusion, two distinct histopathological phenotypes based on liver immune phenotyping are observed in SAH patients, suggesting a separate mechanism driving liver injury and/or failure in these patients. 相似文献
37.
Lugo-Reyes Saul Oswaldo Pastor Nina González-Serrano Edith Yamazaki-Nakashimada Marco Antonio Scheffler-Mendoza Selma Berron-Ruiz Laura Wakida Guillermo Nuñez-Nuñez Maria Enriqueta Macias-Robles Ana Paola Staines-Boone Aide Tamara Venegas-Montoya Edna Alaez-Verson Carmen Molina-Garay Carolina Flores-Lagunes Luis Leonardo Carrillo-Sanchez Karol Niemela Julie Rosenzweig Sergio D. Gaytan Paul Yañez Jorge A. Martinez-Duncker Ivan Notarangelo Luigi D. Espinosa-Padilla Sara Cruz-Munoz Mario Ernesto 《Journal of clinical immunology》2021,41(7):1708-1708
Journal of Clinical Immunology - A Correction to this paper has been published: https://doi.org/10.1007/s10875-021-01075-7 相似文献
38.
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40.
The mycotoxin ochratoxin A (OTA) is a potent nephrocarcinogen, mainly in male rats. The aim of this study was to determine the time course of gene expression (GeneChip® Rat Gene 2.0 ST Array, Affymetrix) in kidney samples from male and female F344 rats, treated daily (p.o) with 0.50 mg/kg b.w. (body weight) of OTA for 7 or 21 days, and evaluate if there were differences between both sexes. After OTA treatment, there was an evolution of gene expression in the kidney over time, with more differentially expressed genes (DEG) at 21 days. The gene expression time course was different between sexes with respect to the number of DEG and the direction of expression (up or down): the female response was progressive and consistent over time, whereas males had a different early response with more DEG, most of them up-regulated. The statistically most significant DEG corresponded to metabolism enzymes (Akr1b7, Akr1c2, Adh6 down-regulated in females; Cyp2c11, Dhrs7, Cyp2d1, Cyp2d5 down-regulated in males) or transporters (Slc17a9 down-regulated in females; Slco1a1 (OATP-1) and Slc51b and Slc22a22 (OAT) down-regulated in males). Some of these genes had also a basal sex difference and were over-expressed in males or females with respect to the other sex. 相似文献