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991.
Singh Ayesha Coulter Amanda R. Trainor Patrick J. Singam Narayana Sarma V. Aladili Bahjat N. Amraotkar Alok R. Owolabi Ugochukwu S. DeFilippis Andrew P. 《Journal of thrombosis and thrombolysis》2021,51(1):120-128
Journal of Thrombosis and Thrombolysis - Platelet activation and subsequent aggregation is a vital component of atherothrombosis resulting in acute myocardial infarction. Therefore, quantifying... 相似文献
992.
Smetana Keaton S. Zakeri Amanda Dolia Jaydevsinh Huttinger Allyson May Casey C. Youssef Patrick Gross Bradley A. Nimjee Shahid M. 《Journal of thrombosis and thrombolysis》2021,52(4):1182-1186
Journal of Thrombosis and Thrombolysis - Tandem occlusions exist in 17–32% of large vessel occlusion (LVO) strokes. A significant concern is bleeding when carotid stenting is performed in... 相似文献
993.
994.
McGinnis Kathleen A. Tate Janet P. Bryant Kendall J. Justice Amy C. O’Connor Patrick G. Rodriguez-Barradas Maria C. Crystal Stephen Cutter Christopher J. Hansen Nathan B. Maisto Stephen A. Marconi Vincent C. Williams Emily C. Cook Robert L. Gordon Adam J. Gordon Kirsha S. Eyawo Oghenowede Edelman E. Jennifer Fiellin David A. 《AIDS and behavior》2022,26(3):786-794
AIDS and Behavior - The timeline followback (TLFB) takes more resources to collect than the Alcohol Use Disorder Identification Test (AUDIT-C). We assessed agreement of TLFB and AUDIT-C with the... 相似文献
995.
Manavotam Singh MD Nitin Malik MD Vijaywant Brar MD Patrick T. Bering MD Cyrus Hadadi MD Farooq H. Sheikh MD Phillip H. Lam MD 《Journal of cardiovascular electrophysiology》2021,32(3):862-866
Sustained ventricular tachycardia and ventricular fibrillation (VF) are life-threatening arrhythmias which remain highly prevalent in patients with advanced heart failure. These ventricular arrhythmias may impair the support provided by continuous-flow left ventricular assist devices (CF-LVADs) and lead to frequent hospitalizations, antiarrhythmic medication use, external defibrillations, and need for heart transplantation. We report a case in which a patient with a CF-LVAD and an implantable cardioverter defibrillator at end of life presented with asymptomatic low-flow alarms and was found to have VF of unknown duration. Unique in our case was the presence of apparent organized contractility and rhythmic opening of the mitral valve on echocardiogram despite VF on electrocardiogram. 相似文献
996.
997.
Lauren L. O'Mahoney PhD Patrick J. Highton PhD Laura Kudlek MSc Jessica Morgan BA Rosie Lynch BA Ella Schofield BMBCh Nayanika Sreejith BA Ajay Kapur BMBCh Afolarin Otunla BA Sven Kerneis BMBCh Olivia James BA Karen Rees PhD Ffion Curtis PhD Kamlesh Khunti FMedSci Jamie Hartmann-Boyce DPhil 《Diabetes, obesity & metabolism》2022,24(9):1850-1860
998.
Gagan Kaur Patrick Baghdasaryan Balaji Natarajan Prabhdeep Sethi Ashis Mukherjee Padmini Varadarajan Ramdas G. Pai 《The International journal of angiology》2021,30(1):15
Coronary no-reflow phenomenon is a lethal mechanism of ongoing myocardial injury, following successful revascularization of an infarct-related coronary artery. Incidence of this phenomenon is high following percutaneous intervention, and is associated with adverse in-hospital and long-term outcomes. Several mechanisms such as ischemia-reperfusion injury and distal microthromboembolism in genetically susceptible patients and those with preexisting endothelial dysfunction have been implicated. However, the exact mechanism in humans is still poorly understood. Several investigative and treatment strategies within and outside the cardiac catheterization laboratory have been proposed, but have not uniformly shown success in reducing mortality or in preventing adverse left ventricular remodeling resulting from this condition. The aim of this article is to provide a brief and concise review of the current understanding of the pathophysiology, clinical predictors, and investigations and management of coronary no-reflow phenomenon. 相似文献
999.
Craig Stephen Harvey Artsob William R Bowie Michael Drebot Erin Fraser Ted Leighton Muhammad Morshed Corinne Ong David Patrick 《The Canadian Journal of Infectious Diseases & Medical Microbiology》2004,15(6):339-344
Zoonoses are fundamental determinants of community health. Preventing, identifying and managing these infections must be a central public health focus. Most current zoonoses research focuses on the interface of the pathogen and the clinically ill person, emphasizing microbial detection, mechanisms of pathogenicity and clinical intervention strategies, rather than examining the causes of emergence, persistence and spread of new zoonoses. There are gaps in the understanding of the animal determinants of emergence and the capacity to train highly qualified individuals; these are major obstacles to preventing new disease threats. The ability to predict the emergence of zoonoses and their resulting public health and societal impacts are hindered when insufficient effort is devoted to understanding zoonotic disease epidemiology, and when zoonoses are not examined in a manner that yields fundamental insight into their origin and spread.EMERGING INFECTIOUS DISEASE RESEARCH SHOULD REST ON FOUR PILLARS: enhanced communications across disciplinary and agency boundaries; the assessment and development of surveillance and disease detection tools; the examination of linkages between animal health determinants of human health outcomes; and finally, cross-disciplinary training and research. A national strategy to predict, prevent and manage emerging diseases must have a prominent and explicit role for veterinary and biological researchers. An integrated health approach would provide decision makers with a firmer foundation from which to build evidence-based disease prevention and control plans that involve complex human/animal/environmental systems, and would serve as the foundation to train and support the new cadre of individuals ultimately needed to maintain and apply research capacity in this area. 相似文献
1000.
Garnero P Landewé R Boers M Verhoeven A Van Der Linden S Christgau S Van Der Heijde D Boonen A Geusens P 《Arthritis and rheumatism》2002,46(11):2847-2856
OBJECTIVE: The known risk factors for radiologic progression in rheumatoid arthritis (RA) are not optimally discriminative in patients with early disease who do not have evidence of radiologic damage. We sought to determine whether urinary C-terminal crosslinking telopeptide of type I (CTX-I) and type II (CTX-II) collagen (markers of bone and cartilage destruction, respectively) are associated with long-term radiologic progression in patients with early RA. METHODS: This was a prospective study of 110 patients with early RA who were participating in the COBRA (Combinatietherapie Bij Reumato?de Artritis) clinical trial and followup study, a randomized controlled trial comparing the efficacy of oral pulse prednisolone, methotrexate, plus sulfasalazine with sulfasalazine alone. We investigated the relationship between baseline levels of urinary CTX-I and CTX-II and the mean annual progression of joint destruction over a median of 4 years, as measured by changes in the modified Sharp score (average of 2 independent readers). RESULTS: In multivariate logistic regression analysis, baseline urinary CTX-I and CTX-II levels in the highest tertile were the strongest predictors of radiologic progression (Sharp score increase >2 units/year; odds ratio 7.9 and 11.2, respectively), independently of treatment group, erythrocyte sedimentation rate (ESR), Disease Activity Score in 28 joints, rheumatoid factor (RF), and baseline joint damage (Sharp score). The likelihood ratios for a positive test were 3.8 and 8.0 for CTX-I and CTX-II, respectively, which compared favorably with the likelihood ratios for the ESR (3.0), baseline joint damage (1.6), and RF (1.8). When patients were grouped according to the presence (Sharp score >/=4, n = 49) and absence (Sharp score <4, n = 61) of joint damage at baseline, CTX-I and CTX-II levels were predictive only in those without baseline joint damage (odds ratio 14.9 and 25.7, respectively). CONCLUSION: High baseline levels of urinary CTX-I and CTX-II independently predict an increased risk of radiologic progression over 4 years in patients with early RA, especially those without radiologic joint damage. Urinary CTX-I and CTX-II may be useful for identifying individual RA patients at high risk of progression very early in the disease, before erosions can be detected radiographically. Such patients may be in special need of treatments that inhibit bone and cartilage degradation. 相似文献