Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells

Introduction  

Inhibitors of cyclo-oxygenase (COX)-2 are being extensively studied as anticancer agents. In the present study we evaluated the mechanisms by which a highly selective COX-2 inhibitor, celecoxib, affects tumor growth of two differentially invasive human breast cancer cell lines.     

The embryo versus endometrium controversy revisited as it relates to predicting pregnancy outcome in in-vitro fertilization-embryo transfer cycles

To evaluate embryonic and endometrial factors for their value in predicting pregnancy outcome in in-vitro fertilization (IVF) and embryo transfer, a retrospective data collection and prospective uterine artery colour Doppler imaging study was performed in a university-based IVF-embryo transfer programme setting. A total of 210 patients were included and grouped as follows: (I) IVF with controlled ovarian stimulation (214 cycles); (II) frozen-thaw cycle of autologous embryos (30 cycles); (III) oocyte donation, no cryopreservation (12 cycles); (IV) frozen-thaw cycle with embryos from donated oocytes (10 cycles). Embryo quality was significantly better in pregnant than non-pregnant cycles (group I, P = 0.0104; groups II-IV, P = 0.0418). The endometrial echo was significantly thicker in pregnant versus non-pregnant patients in group I (P = 0.0059), but not in groups II-IV (P = 0.741). Past uterine surgery or abnormalities had no effect on pregnancy outcome. There were no significant differences in mean uterine artery resistance index or peak systolic velocity in pregnant versus non-pregnant patients in groups II-IV. Thus, embryo quality is the most reliable predictor of pregnancy outcome. Endometrial measurements were significantly thicker in subsequently pregnant patients only in group I, where the endometrium reflects the hormonal environment. Doppler parameters were not useful in predicting pregnancy outcome.      

口腔诊所信息管理系统的研究与开发

目的　研究利用计算机信息处理、数据库和图形技术 ,开发用于口腔诊所 (科室 )的信息管理系统。方法　在专家论证诊所 (科室 )的医疗现状和管理需求的基础上 ,制定我国口腔临床医疗操作代码 ,用PowerBuilder6 .0和SQLAnywhere数据库管理系统为开发工具 ;采用C语言作为图形开发工具 ,进行信息管理系统的研制。结果　该系统含 7个子系统 :患者信息管理、工作人员管理、财务管理、诊所资产管理、消耗品管理、技工委托、系统维护。经 8个单位试用 ,一年中累计管理患者约 110 0例。测试结果表明 ,系统具有较强和较完善的临床使用功能及方便的用户界面。结论　该系统能提高使用单位的临床医疗管理水平和效益。对提高医生的病历水平和积累研究资料也具有重要意义。     

番荔枝种子化学成分研究

从番荔枝Annona squamosa L.种子的乙醇提取物分得三个polyketide类化合物:squamostatin-8(Ⅰ),annonin-vl(Ⅱ)和desacetyluvaricin(Ⅲ)以及胡萝卜甙(daucosterol,IV)。其中Ⅰ是一种新的polyketide,经光谱解析方法,测定了Ⅰ的化学结构式和部分碳原子的立体化学.     

胃癌单克隆抗体临床诊断应用及与CP相关性的探讨

目的：研究胃癌单克隆抗体的表达及临床意义。方法：用本室制备的对胃癌有较强特异性的ＭｃＡｂＧＭＧ１：１Ｄ１－２对１５１例内窥镜活检组织压印片进行免疫组织化学检查。结果：用本法检查组织印片中的癌细胞以及具有癌细胞相关抗原的癌前病变组织,特异性强,反应灵敏,结果可靠,结论：如果与内窥镜和常规病理学检查联合应用,会提高早期癌的检出率,本文还就抗人胃癌ＭｃＡｂ与ＣＰ的相关性进行了初步探讨。