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排序方式: 共有166条查询结果,搜索用时 31 毫秒
91.
Pascaline Aimee Uwineza Monika Urbaniak Marcin Brya ukasz Stpie Marta Modrzewska Agnieszka Wakiewicz 《Toxins》2022,14(5)
The objectives of this research were to obtain the extracts of lemon balm (Melissa officinalis) using supercritical CO2 (SC-CO2) and methanol as co-solvent and evaluate the antifungal activity of those extracts against two selected strains of Fusarium species (Fusarium culmorum and Fusarium proliferatum). The extraction conditions were set at 40 and 60 °C and 250 bar. The obtained extracts were characterized in terms of antifungal activity on potato dextrose agar media (PDA). The results showed that the extraction parameters had different effects on mycelium growth and mycotoxins biosynthesis reduction. All studied lemon balm extracts (1, 2.5, 5, 7.5, and 10%) inhibited the growth of F. proliferatum and F. culmorum mycelia compared to the control. The lemon balm extracts significantly reduced ergosterol content and synthesized mycotoxins in both tested strains. These findings support the antifungal activity of lemon balm extracts against F. proliferatum and F. culmorum. However, more research on other Fusarium species is needed, as well as in vivo applications, before considering lemon balm extracts as a natural alternative to synthetic fungicides. 相似文献
92.
Monika Morak Marta Pineda Alexandra Martins Pascaline Gaildrat Hlne Tubeuf Aurlie Drouet Carolina Gmez Estela Dmaso Kerstin Schaefer Verena Steinke-Lange Udo Koehler Andreas Laner Julie Hauchard Karine Chauris Elke Holinski-Feder Gabriel Capell 《European journal of human genetics : EJHG》2022,30(9):1051
93.
94.
Guillemette Crépeaux Pascaline Bouillaud-KremarikNurgul Sikhayeva Guido RychenRachid Soulimani Henri Schroeder 《Toxicology letters》2013
Polycyclic aromatic hydrocarbons (PAHs) are persistent organic pollutants originating from incomplete combustion processes. Humans are mainly exposed through contaminated food ingestion. PAHs are neurotoxic compounds both for human and rodents, and may be found in placenta, umbilical cord blood and breast milk, suggesting that early exposure may impact developing central nervous system. 相似文献
95.
Anne-Emmanuelle?Priot Pascaline?Neveu Olivier?Sillan Justin?Plantier Corinne?Roumes Claude?PrablancEmail author 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2012,219(4):457-465
According to the eye muscle potentiation (EMP) hypothesis, sustained vergence leads to changes in egocentric perceived distance.
This perceptual effect has been attributed to a change in the resting or tonic state of vergence. The goal of the present
study was to test the EMP hypothesis by quantifying the relationship between prism-induced changes in tonic vergence and corresponding
changes in perceived distance and by measuring the dynamics of changes in perceived distance. During a 10-min exposure to
5-diopter base-out prisms that increased the vergence demand, thirteen right-handed subjects pointed to visual targets located
within reaching space using their left hand, without visual feedback. Pre- and post-exposure tests assessed tonic vergence
through phoria measurements and egocentric distance estimate through pointing to visual targets with each hand successively,
without visual feedback. Similar distance aftereffects were observed for both hands, although only the left hand was used
during exposure, indicating that these aftereffects are mediated by visual processes rather than by visuomotor interactions.
The distance aftereffects were significantly correlated with prism-induced changes in phoria, demonstrating a relationship
between perceived distance and the level of tonic vergence. Changes in perceived distance increased monotonically across trials
during prism exposure and remained stable during the post-test, indicating a long time constant for these perceptual effects,
consistent with current models of the vergence control system. Overall, these results support the hypothesis that vergence
plays a role in reduced-cue distance perception. They further illustrate that variations in tonic vergence influence perceived
distance by altering the sensed vergence effort. 相似文献
96.
97.
Julian-Reynier C Mancini J Mouret-Fourme E Gauthier-Villars M Bonadona V Berthet P Fricker JP Caron O Luporsi E Noguès C 《European journal of human genetics : EJHG》2011,19(5):500-506
In a French national cohort of unaffected females carriers/non-carriers of a BRCA1/2 mutation, long-term preventive strategies and breast/ovarian cancer risk perceptions were followed up to 5 years after test result disclosure, using self-administered questionnaires. Response rate was 74%. Carriers (N=101) were younger (average age ± SD=37 ± 10) than non-carriers (N=145; 42 ± 12). There were four management strategies that comprised 88% of the decisions made by the unaffected carriers: 50% opted for breast surveillance alone, based on either magnetic resonance imaging (MRI) and other imaging (31%) or mammography alone (19%); 38% opted for either risk reducing salpingo-oophorectomy (RRSO) and breast surveillance, based on MRI and other imaging (28%) or mammography alone (10%). The other three strategies were: risk reducing mastectomy (RRM) and RRSO (5%), RRM alone (2%) and neither RRM/RRSO nor surveillance (6%). The results obtained for various age groups are presented here. Non-carriers often opted for screening despite their low cancer risk. Result disclosure increased carriers' short-term high breast/ovarian cancer risk perceptions (P ≤ 0.02) and decreased non-carriers' short- and long-term perceptions (P<0.001). During follow-up, high breast cancer risk perceptions increased with time among those who had no RRM and decreased in the opposite case; high ovarian cancer risk perceptions increased further with time among those who had no RRSO and decreased in the opposite case; RRSO did not affect breast cancer risk perceptions. Informed decision-making involves letting women know whether opting for RRSO and breast MRI surveillance is as effective in terms of survival as RRM and RRSO. 相似文献
98.
Dubois Cauwelaert N Ramarokoto H Ravololonandriana P Richard V Rasolofo V 《Journal of clinical microbiology》2011,49(10):3600-3603
We examined the feasibility of using DNA extracted from stained sputum smears for the detection of rifampin and isoniazid resistance with the commercial MTBDRplus assay from Hain Lifescience GmbH, Nehren, Germany. Overall sensitivity was initially low (70.0%) but increased to 96.7% when a multiplex PCR preamplification step was added. We then tested stored Mycobacterium tuberculosis-positive stained smears prepared from 297 patients' sputum samples. Species identification and drug susceptibility testing (DST) had been performed at the Institut Pasteur de Madagascar. Overall, the performance of the MTBDRplus assay applied to slide DNA was similar to that obtained in other studies with DNA extracted from clinical specimens. With the ready availability of stained smears in routine diagnostic laboratories and their easy transport and storage at room temperature, this approach should be useful for optimizing the treatment of multidrug-resistant tuberculosis and for conducting resistance surveys aimed at identifying hot-spot regions and breaking chains of transmission. 相似文献
99.
Here, we address the question of whether normal aging influences action representation by comparing the ability of 14 young (age: 23.6 +/- 2.1 years) and 14 older (age: 70.1 +/- 4.5 years) adults to mentally simulate arm movements under a varying dynamic context. We conducted two experiments in which we experimentally manipulated the gravity and inertial components of arm dynamics: (i) unloaded and loaded vertical arm movements, rotation around the shoulder joint, (ii) unloaded and loaded horizontal arm movements, rotations around the shoulder and elbow joints, in two directions (inertial anisotropy phenomenon). The main findings indicated that imagery ability was equivalent between the two groups of age for the unloaded arm movements, but better for the young than the older group, for the loaded arm movements. For the horizontal movements, we found better imagery ability for the young than the older adults for both movement directions and loads. Finally, young and old adults showed low (<8%)-temporal variability for both overt and covert arm movements in all conditions. Our findings showed a specific decline of action representation in the aging brain and suggest that internal models of action become imprecise with advance in age. This is not exact to say that there is a severe impairment of motor prediction in old adults as they can mentally represent their arm movements with high-temporal consistency. Finally, we propose that motor imagery could be used as a therapeutic tool for motor rehabilitation in aged adults. 相似文献