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81.
Intensive chemotherapy for peripheral T-cell lymphomas. 总被引:3,自引:0,他引:3
Forty-two patients with previously untreated peripheral T-cell lymphomas (PTCL) were treated with an intensive chemotherapy protocol. Either the BACOP or the m-BACOD regimen was used for induction. Patients achieving complete clinical remission after three courses were given intensive consolidation and maintenance chemotherapy similar to the L10/L17M protocol designed by the Memorial Sloan-Kettering Group for acute lymphoblastic leukemia and lymphoblastic lymphoma. There were 27 (64 per cent) males and 15 (36 per cent) females. The median age was 54 years (mean 53, range 15 to 68). Seven of them (17 per cent) had stage I disease, four (10 per cent) stage II, seven (17 per cent) stage III and 24 (57 per cent) stage IV. Eighteen patients (43 per cent) had B symptoms and four (10 per cent) had bulky disease. According to the Working Formulation, the histology was diffuse mixed in 16 patients (38 per cent), diffuse large cell in 18 (43 per cent), diffuse immunoblastic in four (10 per cent) and unclassifiable in four (10 per cent). According to a modified Japanese Lymphoma Study Group's classification, the histology in 24 patients (57 per cent) was the pleomorphic type, in 13 (31 per cent) immunoblastic-lymphadenopathy-like (IBL-like), and in five (12 per cent) unclassifiable. The overall complete remission rate was 67 per cent. Twenty-five per cent of the complete responders relapsed and the DFS of the CR patients was 62 per cent at three years. The overall survival of all patients at three years was 52 per cent. Patients with stage I, II and III disease had significantly better CR rate (100 per cent versus 42 per cent, p = 0.001) and overall survival (82 per cent versus 35 per cent at three years, p = 0.01) than those with stage IV disease but the relapse rate and DFS of CR patients were similar. This study shows that the prognosis of patients with PTCL can be improved by intensive therapy. 相似文献
82.
83.
Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine 总被引:2,自引:0,他引:2
J B Clarke K Neftel N R Kitteringham B K Park 《International archives of allergy and applied immunology》1991,95(4):369-375
Antidrug IgG antibodies have been detected in some patients receiving amodiaquine (AQ). Antidrug antibodies were detected in 6/7 patients who experienced serious well-defined adverse drug reactions during malaria prophylaxis and in 7/22 patients who received comparable doses of the drug (at least 400 mg weekly x 6) but did not present with clinical adverse drug reactions. In contrast antidrug antibodies were not detected in 7 patients who received the drug for treatment (1.0-1.2 g total over 3 days). The specificity of the IgG response was defined by hapten inhibition experiments (IC50 value for AQ ranged between 0.050 and 0.282 microM) which suggest that the antibody recognised the drug linked to cysteine residues in protein via the 4-hydroxyanilino side chain. The data show that AQ is immunogenic in man and are consistent with the hypothesis that idiosyncratic adverse reactions to the drug have an immunological aetiology. 相似文献
84.
85.
86.
The methanol extract of Cinnamomi Cortex showed antibacterial action against cariogenic bacterium,Streptococcus mutans OMZ 176. The active principle of the extract was identified to betrans-cinnamaldehyde, which was bactericidal in the minimal inhibitory concentration (MIC) of 100 μg/ml againt the strain. From the results of antibacterial activity of cinnamaldehyde and its derivatives, the acrolein group in the cinnamal-dehyde was elucidated to be an essential element for the activity. 相似文献
87.
M Shaves D Barnhill J Bosscher S Remmenga M Hahn R Park 《Obstetrics and gynecology》1991,77(4):642-644
Seven patients with severe pain caused by an advanced, incurable gynecologic malignancy were treated with an indwelling epidural catheter connected to an implantable subcutaneous port through which morphine was infused. There were few major complications associated with insertion or maintenance of the system. The average usage was 60 days, although the system functioned continuously for 6 months in one patient. Pain distribution in these women ranged from the upper abdomen to the lower extremities. All patients, including one with liver metastases, reported good to excellent pain control with the epidural narcotics. Two subjects with upper abdominal pain occasionally required supplemental oral oxycodone, but the other five patients had adequate pain relief with the epidural system alone. The indwelling epidural system provides excellent analgesia for patients with advanced, incurable gynecologic cancer. 相似文献
88.
Selective inactivation of viruses in the presence of human platelets: UV sensitization with psoralen derivatives. 下载免费PDF全文
R P Goodrich N R Yerram B H Tay-Goodrich P Forster M S Platz C Kasturi S C Park N J Aebischer S Rai L Kulaga 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(12):5552-5556
Inactivation of viruses in blood products requires that the method employed display selectivity in its action for viral elements while not affecting the biological entity of interest. Several methods have been developed for the treatment of human plasma or products derived from human plasma. An effective technique for the treatment of the cellular components of blood has been lacking, in part due to the inability to develop agents capable of selectively targeting viral agents in the milieu of cellular material. In this paper, we examine the behavior of a group of viral sensitizers designed to be added to cellular samples and be activated upon exposure to UVA light. Upon activation, these agents are capable of disrupting nucleic acids of the virus in a manner that renders them inactive for proliferation. The selectivity observed in this inactivation is determined by the chemical structure of the sensitizer, which can be varied to increase viral killing capacity while diminishing collateral damage to cellular and protein constituents. 相似文献
89.
Effects of inotropes on human leucocyte numbers, neutrophil function and lymphocyte subtypes 总被引:1,自引:1,他引:0
Burns A. M.; Keogan M.; Donaldson M.; Brown D. L.; Park G. R. 《British journal of anaesthesia》1997,78(5):530-535
We have investigated the effects of inotropes with different adrenergic
receptor specificity on differential white cell count, lymphocyte subtypes
and neutrophil function in healthy volunteers. Six healthy, male volunteers
were enrolled into this randomized, placebo-controlled pilot study. Each
volunteer was studied on four separate occasions during a 2-h infusion of
various agents, and for 2 h after stopping the infusion. The agents
investigated were adrenaline 0.1 microgram kg-1 min-1, dobutamine 5
micrograms kg-1 min-1, dopexamine 2 micrograms kg-1 min-1 and 5% glucose
0.5 ml kg-1 h-1. Venous blood was sampled at 0, 30, 120 and 240 min.
Haemodynamic monitoring was continued throughout the study. Full blood
count, white cell differential count and enumeration of lymphocyte subtypes
were performed. Neutrophil function tests included chemoluminescence, and
assessment of neutrophil chemotaxis, phagocytosis and adhesion. The
Wilcoxon signed rank test was used to compare differences between placebo
and active drugs at each time compared with baseline. There was a
significant increase in white cell count, lymphocyte count and neutrophil
count with adrenaline, and a small but significant decrease in these
variables with dobutamine and dopexamine. These changes were also apparent
for absolute CD3+, CD4+ and CD8+ lymphocyte counts. Neutrophil respiratory
burst in response to f-methionyl-leucyl-phenylalanine increased
significantly only with adrenaline at 30 min (P = 0.046). There were no
other significant changes in tests of neutrophil function. Infusion of
inotropes was associated with changes in white cell numbers, lymphocyte
subtypes and neutrophil respiratory burst. In healthy volunteers,
adrenaline had effects different from those of dobutamine and dopexamine.
The clinical relevance of such effects requires further investigation in
critically ill patients.
相似文献
90.
T M Ko C Y Hsieh H N Ho F J Hsieh T Y Lee 《American journal of obstetrics and gynecology》1991,164(3):901-906
To determine the genetic origin of the complete hydatidiform mole, 20 abnormal pregnancies were studied with restriction fragment length polymorphism with five genomic probes: EJ 6.6, beta-globin gene, 3'alpha-hypervariable region, J-Bir, and St14. In the 12 cases of molar pregnancy, pure paternal origin was proved in 11 cases, but both maternal and paternal inheritance were shown in only one case. In the cases with pure paternal origin, all of the restriction fragment length polymorphisms were homozygous, although those of the fathers were heterozygous at 15 loci. In the four cases that mimicked hydatidiform mole but were diagnosed as hydropic change of villi, both paternal and maternal inheritance were noted. In the four pregnancies with blighted ovum, both paternal and maternal inheritance were shown in three cases; and in one case with a balanced translocation between chromosomes 13 and 14, only paternal inheritance was noted. This study showed that most of the complete hydatidiform moles were caused by fertilization of an empty egg by a duplicated haploid sperm, but rare exceptions may exist. 相似文献