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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
足组织缺损的显微修复 总被引:15,自引:11,他引:4
1984年~1994年共收治各种足部组织创伤缺损236例,均采用显微外科技术进行组织移植修复,其中单纯皮瓣移植修复187例,复合皮瓣移植修复49例。吻合血管游离移植修复97例,带血管蒂移位修复139例。4例前足缺损者用带肩胛骨的复合皮瓣移植修复,6例足跟严重缺损者用带血管的腓骨复合皮瓣移植修复。经1~10年随访,皮瓣、复合皮瓣、移植或再植的骨骨各全部成活,愈合良好,足功能基本得到恢复,可行走、负重,186例恢复了原工作。认为,恢复足部结构完整与重建足跟、足底的感觉是获得良好功能的关键 相似文献
32.
Viral markers were studied in 79 cases of viral hepatitis with hepatic failure. The results were shown as follows: 8 cases were positive for anti-HAV IgM (10.12%); 76 cases positive for HBsAg or anti-HBc IgM (96.20%) and 41 cases positive for anti-HCV antibodies (51.89%). Among those with anti-HCV positive, 35 cases were co-infected with HBV, 5 cases with HAV and/or HCV, only one was infected with HCV alone 2 cases were HD-Ag positive (2.52%) and one not identified (1.27%). With the reference of clinical findings, patients co-infected with HBV/HCV or anti-HBc IgM positive were more critical and usually entail higher mortality. In cases with HCV co-infections, the positive HBV replication markers seems to be reduced. Hepatic failure without HBV replicative markers had a high rate of hepatic coma as well as poor outcome. 相似文献
33.
本文对5例典型尖锐湿疣标本及10例可疑人乳头瘤病毒感染标本进行透射电子显微镜观察。结果典型尖锐湿疣标本中仅1例于细胞核内见到人乳头瘤病毒,排列规则呈结晶状。其余14例标本的细胞内均见不同程度的由病毒感染所引起的非特异性病理变化。本文对人孔头瘤病毒及受感染细胞的超微结构进行了初步探讨。 相似文献
34.
应用单链构象多态性分析多聚酶链反应EB染色法(PCR-SSCP-EB)对40例肺癌组织标本的P53基因序列5~8外显子突变进行分析,同时应用PCR方法检测上述标本及18例肺良性疾病组织标本中HPV16、18型DNA相关序列,旨在分析二者在肺鳞癌发病中的作用及相互关系,并就肺鳞癌与P53基因结构和功能异常的关系进行初步探讨。 相似文献
35.
Xian ZH Zhang SH Cong WM Wu WQ Wu MC 《第二军医大学学报》2005,26(11):1320-1320
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent fatal cancers in the world. Despite advances in early diagnosis and improvements in surgical techniques, the survival of patients with HCC even after resection is poor because of the high incidence of recurrences. Therefore, the identification of prognostic factors may be helpful in the development of new treatment protocols. AIMS: To investigate HER-2/neu status in HCC by immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH), and to explore the possibility of using trastuzumab in the treatment of HCC. METH ODS: Eight hundred and sixty eight surgical samples from patients with primary HCC were examined for their HER-2/neu status. IHC for HER-2/neu was performed with the HercepTest kit; FISH analysis was performed with the PathVysion HER-2 DNA probe kit. The correlations between HER-2/neu overexpression and clinicopathological characteristics were analysed statistically. RESULTS: HER-2/neu overexpression was detected in 21 (2.42%) of the 868 primary HCCs. Only one specimen showed HER-2/neu gene amplification by FISH. No significant associations were found between HER-2/neu overexpression and the clinicopathological parameters. CONCLUSIONS: There is a low frequency of HER-2/neu overexpression/amplification in HCC. There appears to be no role for HER-2/neu as a prognostic marker and no benefit of anti-HER-2/neu trastuzumab treatment in patients with HCC. 相似文献
36.
目的 了解本社区高血压患者的危险因素现状,探讨干预对策。方法 采用分层整群抽样的方法,随机抽取社区4个里委2级、3级高血压患者402例作为研究对象,收集各项危险因素如性别、年龄、血脂、血糖、吸烟、饮食、体育锻炼、体重等,并进行统计分析。结果402例高血压患者1年内进行所有相关辅助检查者有14例,占3.48%;1年内进行相关辅助检查一项者306例,占76.12%。饮食控制及进行体育锻炼有300例,占74.43%;吸烟62例,占15.42%。结论 高血压患者对饮食控制及体育锻炼、吸烟有害的知晓率明显提高,而对相关辅助检查认识不足。 相似文献
37.
Pan Jing-xin Guo Yi-bin Guo Xi-zhe Guo Jian-xin Chen Yun-feng Wang Zhi-dong 《中国结合医学杂志》2004,10(1):36-39
Objective: To explore the effect of Shenfu Injection, SFI) on the secondary aplastic anemia (AA) of tumor patients after chemotherapy
(CT).Methods: The 15 cases of SFI treated group, 10 cases of control group, 25 cases of SFI + granulocyte-macrophage colony stimulating
factor (GMCSF) treated group and the group of 23 GM-CSF-treated tumor cases of secondary AA after CT were compared, with their
increasing rate and the rebound speed of neutrophil, platelet, bone marrow nucleated RBC, granulocyte, and megakaryocyte all
being investigated.Results: The increasing rate and rebound speed of granulocyte, platelet, and the increasing rate of bone marrow nucleated RBC, granulocyte,
megakaryocyte were obviously higher than those of the control, and the clinical manifestations were also obviously improved.
The increasing rate of platelet, bone marrow nucleated RBC, megakaryocyte of the SFI + GM-CSF group were higher than those
of the group which used GM-CSF alone, while the increasing rate of granulocyte in blood and bone marrow in both groups was
similar.Conclusion: Significant efficacy was shown in SFI for the treatment of secondary AA of tumor patients after CT. 相似文献
38.
The blood–brain barrier (BBB) is an immense neurovascular interface. In neurodegenerative, ischemic, and traumatic disorders of the central nervous system (CNS), the BBB may hinder the delivery of many therapeutic peptides and proteins to the brain and spinal cord. Fortunately, the mistaken dogma that peptides and proteins do not cross the BBB has been corrected during the past two decades by the accumulating evidence that peptides and proteins in the periphery exert potent effects in the CNS. Not only can peptides and proteins serve as carriers for selective therapeutic agents, but they themselves may directly cross the BBB after delivery into the bloodstream. Their passage may be mediated by simple diffusion or specific transport, both of which can be affected by interactions in the blood compartment (outside the BBB) and within the endothelial cells (at the BBB level). Although the majority of current delivery strategies focuses on modification of the molecule to be delivered, understanding the mechanisms of transport will eventually facilitate regulation of the BBB directly. We review the different aspects of interactions and discuss recent advances in the cell biology of peptide/protein transport across the BBB. Better understanding of the nature and regulation of the transport systems at the BBB will provide a new direction to enhance the interactions of peripheral peptides and proteins with the CNS. 相似文献
39.
肾上腺皮质腺癌的诊断与治疗 总被引:2,自引:0,他引:2
目的 探讨肾上腺皮质腺癌的早期诊断、手术及围手术期处理。方法 回顾分析了1990年至2001年间31例肾上腺皮质腺癌临床资料.并与1978年至1989年同种病例作比较。结果 近10年患者病理分期更趋向早期,更易行根治性切除,5年的存活率明显提高。结论 影像学的发展,使患者易早期诊断;围手术期的充分准备是减少手术并发症及死亡率的关键。 相似文献
40.
目的探讨声敏剂血卟啉衍生物在肿瘤组织中的富集情况,以便在给药后超声结合血卟啉治疗肿瘤时选择最佳的超声处理时间。方法H-22肝癌荷瘤小鼠尾静脉注射HpD后,不同时间点取材,采用荧光分光光度法测定不同组织提取液中HpD的荧光强度,研究HpD在不同组织中的分布以及代谢变化。结果给药后2 h肿瘤组织以外的其他各组织内(血浆、肝、肾、皮肤、肌肉)血卟啉含量均达到其代谢过程的最高点,后逐渐下降;肿瘤组织中的HpD含量注射后不断上升,6 h时达到顶峰,随后又开始下降,10~24 h代谢比较缓慢,表现为肿瘤组织中对HpD的滞留作用,24 h时肿瘤组织中的HpD含量高于其他各组织,48~72 h趋于稳定在较低水平。结论提出了不同部位的肿瘤应选择各自适当的时间点进行超声处理。 相似文献