全文获取类型
收费全文 | 2378195篇 |
免费 | 195135篇 |
国内免费 | 4217篇 |
专业分类
耳鼻咽喉 | 34398篇 |
儿科学 | 72933篇 |
妇产科学 | 63132篇 |
基础医学 | 335364篇 |
口腔科学 | 67563篇 |
临床医学 | 215708篇 |
内科学 | 469283篇 |
皮肤病学 | 47958篇 |
神经病学 | 201065篇 |
特种医学 | 96035篇 |
外国民族医学 | 886篇 |
外科学 | 360697篇 |
综合类 | 56232篇 |
现状与发展 | 1篇 |
一般理论 | 978篇 |
预防医学 | 190829篇 |
眼科学 | 55592篇 |
药学 | 178043篇 |
4篇 | |
中国医学 | 4378篇 |
肿瘤学 | 126468篇 |
出版年
2018年 | 24298篇 |
2016年 | 20654篇 |
2015年 | 23359篇 |
2014年 | 33643篇 |
2013年 | 50989篇 |
2012年 | 68991篇 |
2011年 | 72562篇 |
2010年 | 42593篇 |
2009年 | 40928篇 |
2008年 | 68933篇 |
2007年 | 73286篇 |
2006年 | 74204篇 |
2005年 | 72235篇 |
2004年 | 69580篇 |
2003年 | 67220篇 |
2002年 | 66449篇 |
2001年 | 112518篇 |
2000年 | 116602篇 |
1999年 | 98391篇 |
1998年 | 27878篇 |
1997年 | 25534篇 |
1996年 | 25459篇 |
1995年 | 24616篇 |
1994年 | 23168篇 |
1993年 | 21556篇 |
1992年 | 79416篇 |
1991年 | 76425篇 |
1990年 | 73605篇 |
1989年 | 70871篇 |
1988年 | 65885篇 |
1987年 | 64818篇 |
1986年 | 61364篇 |
1985年 | 58433篇 |
1984年 | 44238篇 |
1983年 | 37678篇 |
1982年 | 22902篇 |
1981年 | 20340篇 |
1980年 | 19043篇 |
1979年 | 41314篇 |
1978年 | 28996篇 |
1977年 | 24357篇 |
1976年 | 22847篇 |
1975年 | 23994篇 |
1974年 | 29653篇 |
1973年 | 28056篇 |
1972年 | 26233篇 |
1971年 | 24163篇 |
1970年 | 22760篇 |
1969年 | 21095篇 |
1968年 | 19146篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
931.
Catecholaminergic polymorphic ventricular tachycardia is important to be diagnosed as an underlying disease in children with syncope and normal heart, because of its poor prognosis. CASE REPORT: A 3-year-old boy was referred for stress and emotion induced syncope. Primary ventricular arrhythmia, consisting of salvos of bidirectional ventricular tachycardia, was reproducibly induced by physical exertion. The syncopal events and severe arrhythmia disappeared with beta-blocking therapy. CONCLUSION: Despite its rare occurrence, catecholaminergic polymorphic ventricular tachycardia is an important cause of stress and emotion induced syncope and sudden death in children. 相似文献
932.
933.
934.
935.
Scott S Auerbach Joshua G Dekeyser Matthew A Stoner Curtis J Omiecinski 《Drug metabolism and disposition》2007,35(3):428-439
The constitutive androstane receptor (CAR; NR1I3) regulates the expression of genes involved in xenobiotic metabolism. Alternative splicing of the human CAR gene yields an array of mRNAs that encode structurally diverse proteins. One form of CAR, termed CAR2, contains an additional four amino acids (SPTV) that are predicted to reshape the ligand-binding pocket. The current studies show a marked, ligand-independent, CAR2-mediated transactivation of reporters containing optimal DR-3, DR-4, and DR-5 response elements, and reporters derived from the natural CYP2B6 and CYP3A4 gene promoters. Overexpression of the RXRalpha ligand binding domain was critical for achieving these effects. CAR2 interaction with SRC-1 was similarly dependent on the coexpression of RXRalpha. Mutagenesis of Ser233 (SPTV) to an alanine residue yielded a receptor possessing higher constitutive activity. Alternatively, mutating Ser233 to an aspartate residue drastically reduced the transactivation capacity of CAR2. The respective abilities of these mutagenized forms of CAR2 to transactivate a DR-4 x 3 reporter element correlated with their ability to interact with RxRalpha and to recruit SRC-1 in a ligand-regulated manner. Together, these results demonstrate a robust RXRalpha-dependent recruitment of coactivators and transactivation by CAR2. In addition, CAR2 displays novel dose responses to clotrimazole and androstanol compared with the reference form of the receptor while at the same time retaining the ability to bind CITCO. This result supports a hypothesis whereby the four-amino-acid insertion in CAR2 structurally modifies its ligand binding pocket, suggesting that CAR2 is regulated by a set of ligands distinct from those governing the activity of reference CAR. 相似文献
936.
937.
938.
939.
940.