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51.
In contrast to the murine system, long-term hamster bone marrow suspension cultures maintain proliferation of both pluripotent and committed stem cells in the absence of an adherent layer and without addition of exogenous factors, such as hydrocortisone. Addition of pokeweed-mitogen-stimulated hamster spleen conditioned medium (SCM) to these long-term suspension cultures produces an increase in the number of mixed colonies assayed in soft-agar, These mixed colonies, which contained four cell lineages--granulocytic, erythroid, megakaryocytic, and macrophage--could be generated from cells grown in suspension for over 6 mo. Addition of SCM also induces an initial rapid expansion of the myeloid compartment, and this expansion results in 70% of the cells being terminally differentiated granulocytes. In contrast, addition of SCM to hamster bone marrow cultures containing both adherent cells and hematopoietic stem cells produced no change in the number of mixed colonies generated in the culture. This system allows the in vitro study of the process of stem cell proliferation and differentiation and also provides a means to examine the relationship of adherent and supernatant bone marrow populations. 相似文献
52.
Cardiac Resynchronization Therapy Delivered Via a Multipolar Left Ventricular Lead is Associated with Reduced Mortality and Elimination of Phrenic Nerve Stimulation: Long‐Term Follow‐Up from a Multicenter Registry 下载免费PDF全文
JONATHAN M. BEHAR M.B.B.S. M.R.C.P. JULIAN BOSTOCK Ph.D. F.H.R.S. ADRIAN PO ZHU LI B.A. B.M.B.Ch. HUI MEN SELINA CHIN B.A. STEPHEN JUBB B.A. B.M.B.Ch. EDWARD LENT B.A.B.M. B.Ch. JAMES GAMBLE M.B.B.S. M.R.C.P. PAUL W.X. FOLEY M.D. F.R.C.P. TIM R. BETTS M.D. F.R.C.P. CHRISTOPHER ALDO RINALDI M.D. F.R.C.P. F.H.R.S. NEIL HERRING D.Phil. M.R.C.P. 《Journal of cardiovascular electrophysiology》2015,26(5):540-546
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A long‐term prospective cohort study on immediately restored single tooth implants inserted in extraction sockets and healed ridges: CBCT analyses,soft tissue alterations,aesthetic ratings,and patient‐reported outcomes 下载免费PDF全文
54.
Chappuis F Pittet A Bovier PA Adams K Godineau V Hwang SY Magnus E Büscher P 《Tropical medicine & international health : TM & IH》2002,7(11):942-948
Most Human African Trypanosomiasis (HAT) control programmes in areas endemic for Trypanosoma brucei gambiense rely on a strategy of active mass screening with the Card Agglutination Test for Trypanosomiasis (CATT)/T. b. gambiense. We evaluated the performance, stability and reproducibility of the CATT/T. b. gambiense on blood-impregnated filter papers (CATT-FP) in Kajo-Keji County, South-Sudan, where some areas are inaccessible to mobile teams. The CATT-FP was performed with a group of 100 people with a positive CATT on whole blood including 17 confirmed HAT patients and the results were compared with the CATT on plasma (CATT-P). The CATT-FP was repeated on impregnated filter papers stored at ambient and refrigerated temperature for 1, 3, 7 and 14 days. Another 82 patients with HAT, including 78 with a positive parasitology, were tested with the CATT-FP and duplicate filter paper samples were sent to a reference laboratory to assess reproducibility. The CATT-FP was positive in 90 of 99 patients with HAT (sensitivity: 91%). It was less sensitive than the CATT-P (mean dilution difference: -2.5). There was no significant loss of sensitivity after storage for up to 14 days both at ambient and cool temperature. Reproducibility of the CATT-FP was found to be excellent (kappa: 0.84). The CATT-FP can therefore be recommended as a screening test for HAT in areas where the use of CATT-P is not possible. Further studies on larger population samples in different endemic foci are still needed before the CATT-FP can be recommended for universal use. 相似文献
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YOUNG SOO LEE M.D. Ph.D. PO‐CHENG CHANG M.D. CHIA‐HSIANG HSUEH Ph.D. MITSUNORI MARUYAMA M.D. Ph.D. HYUNG WOOK PARK M.D. Ph.D. KYOUNG‐SUK RHEE M.D. Ph.D. YU‐CHENG HSIEH M.D. Ph.D. CHANGYU SHEN Ph.D. JAMES N. WEISS M.D. ZHENHUI CHEN Ph.D. SHIEN‐FONG LIN Ph.D. PENG‐SHENG CHEN M.D. 《Journal of cardiovascular electrophysiology》2013,24(10):1144-1153
57.
YU LIU M.D. BENJAMIN J. SCHERLAG Ph.D. YOUQI FAN M.D. VANDANA VARMA M.D. SHAILESH MALE M.D. MUHAMMAD A. CHAUDHRY M.D. CONGXIN HUANG M.D. Ph.D. SUNNY S. PO M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2013,24(2):188-195
Autonomic Blockade and Atrial Fibrillation . Background: Recent clinical reports that used cholinergic and adrenergic blockade (CAB) as an alternative to ganglionated plexi (GP) ablation to terminate atrial fibrillation (AF) showed mixed results. We investigated the role of other neurotransmitters in AF inducibility. Methods: In 23 pentobarbital anesthetized dogs, a left and right thoracotomy allowed the attachment of electrode catheters to the left and right pulmonary veins and atrial appendages (AA). Programmed stimulation was used to determine the effective refractory periods (ERP) and AF inducibility, measured by the window of vulnerability (WOV). AF duration in response to acetylcholine (Ach; 100 mM) applied to the AA was measured before and after GP ablation + CAB and with vagus nerve stimulation (VNS). After GP ablation + CAB, Ach induced AF duration was determined in response to vasoactive intestinal peptide (VIP) and its specific antagonist ([Ac‐Tyr1,D‐phe2]‐VIP). Results: GP ablation + CAB significantly prolonged ERP, eliminated WOV, and suppressed the duration of Ach induced AF (P ≤ 0.01 for all). Also slowing of the heart rate by VNS was essentially blocked; however, with Ach 100 mM applied to the AA, VNS, and VIP applied to the AA markedly prolonged AF duration. This effect was blocked by the VIP antagonist. Conclusions: Neither GP ablation nor CAB can fully suppress AF inducibility arising from the atrial neural network. Our findings suggest that other neurotransmitters, such as VIP released during VNS, can promote sustained AF despite GP ablation and “autonomic blockade,” which may further define the substrate for AF outside the pulmonary vein‐atrial junctions. (J Cardiovasc Electrophysiol, Vol. 24, pp. 188‐195, February 2013) 相似文献
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Cedric P Yansouni Emmanuel Bottieau Pascal Lutumba Andrea S Winkler Lut Lynen Philippe Büscher Jan Jacobs Philippe Gillet Veerle Lejon Emilie Alirol Katja Polman Jürg Utzinger Michael A Miles Rosanna W Peeling Jean-Jacques Muyembe François Chappuis Marleen Boelaert 《The Lancet infectious diseases》2013,13(6):546-558