全文获取类型
收费全文 | 1521篇 |
免费 | 59篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 87篇 |
妇产科学 | 11篇 |
基础医学 | 121篇 |
口腔科学 | 39篇 |
临床医学 | 152篇 |
内科学 | 243篇 |
皮肤病学 | 22篇 |
神经病学 | 37篇 |
特种医学 | 427篇 |
外科学 | 138篇 |
综合类 | 24篇 |
预防医学 | 108篇 |
眼科学 | 16篇 |
药学 | 61篇 |
中国医学 | 1篇 |
肿瘤学 | 127篇 |
出版年
2022年 | 6篇 |
2021年 | 13篇 |
2020年 | 7篇 |
2019年 | 9篇 |
2018年 | 31篇 |
2017年 | 21篇 |
2016年 | 21篇 |
2015年 | 33篇 |
2014年 | 37篇 |
2013年 | 57篇 |
2012年 | 51篇 |
2011年 | 55篇 |
2010年 | 66篇 |
2009年 | 65篇 |
2008年 | 56篇 |
2007年 | 79篇 |
2006年 | 63篇 |
2005年 | 80篇 |
2004年 | 51篇 |
2003年 | 40篇 |
2002年 | 31篇 |
2001年 | 49篇 |
2000年 | 40篇 |
1999年 | 38篇 |
1998年 | 54篇 |
1997年 | 55篇 |
1996年 | 55篇 |
1995年 | 43篇 |
1994年 | 44篇 |
1993年 | 39篇 |
1992年 | 26篇 |
1991年 | 25篇 |
1990年 | 13篇 |
1989年 | 25篇 |
1988年 | 57篇 |
1987年 | 28篇 |
1986年 | 25篇 |
1985年 | 38篇 |
1984年 | 9篇 |
1983年 | 5篇 |
1982年 | 6篇 |
1981年 | 13篇 |
1980年 | 9篇 |
1979年 | 10篇 |
1978年 | 5篇 |
1977年 | 6篇 |
1976年 | 13篇 |
1975年 | 7篇 |
1974年 | 4篇 |
1972年 | 2篇 |
排序方式: 共有1620条查询结果,搜索用时 15 毫秒
991.
992.
Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutical evaluation of patients with multiple myeloma 总被引:1,自引:0,他引:1
Susanne Lütje Jacky W. J. de Rooy Sandra Croockewit Emmeline Koedam Wim J. G. Oyen Reinier A. Raymakers 《Annals of hematology》2009,88(12):1161-1168
Multiple myeloma is a malignant B-cell neoplasm that involves the skeleton in approximately 80% of the patients. With an average
age of 60 years and a 5-years survival of nearly 45% Brenner et al. (Blood 111:2516–2520, 35) the onset is to be classified as occurring still early in life while the disease can be very aggressive and debilitating.
In the last decades, several new imaging techniques were introduced. The aim of this review is to compare the different techniques
such as radiographic survey, multidetector computed tomography (MDCT), whole-body magnetic resonance imaging (WB-MRI), fluorodeoxyglucose
positron emission tomography- (FDG-PET) with or without computed tomography (CT), and 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy. We conclude that both FDG-PET in combination with low-dose CT and whole-body MRI are more sensitive
than skeleton X-ray in screening and diagnosing multiple myeloma. WB-MRI allows assessment of bone marrow involvement but
cannot detect bone destruction, which might result in overstaging. Moreover, WB-MRI is less suitable in assessing response
to therapy than FDG-PET. The combination of PET with low-dose CT can replace the golden standard, conventional skeletal survey.
In the clinical practise, this will result in upstaging, due to the higher sensitivity. 相似文献
993.
Huub J J M Rennen Otto C Boerman Wim J G Oyen Frans H M Corstens 《Journal of nuclear medicine》2003,44(9):1502-1509
The cytokine interleukin-8 (IL-8) binds with high affinity to the CXCR1 and CXCR2 receptors on neutrophils. In previous studies, we showed that (99m)Tc-IL-8 could rapidly and effectively delineate foci of infection and inflammation in rabbit models of intramuscular infection, colitis, and osteomyelitis. Here, the in vivo kinetics and pharmacodynamics of (99m)Tc-IL-8 are studied in detail. A derivative of hydrazinonicotinamide (HYNIC) was used as a bifunctional coupling agent to label the protein with (99m)Tc. METHODS: To address specificity of uptake of (99m)Tc-IL-8 in the abscess, uptake in turpentine-induced abscesses in neutropenic rabbits was compared with uptake in turpentine-induced abscesses in normal rabbits. The pharmacokinetics of (99m)Tc-IL-8 were studied in neutropenic rabbits and compared with those in normal rabbits. To investigate the interaction of (99m)Tc-IL-8 with blood cells in circulation in normal rabbits, the distribution of the radiolabel over circulating white and red blood cells and plasma was determined. The in vivo kinetics of (99m)Tc-IL-8 were studied by quantitative analysis of whole-body images acquired between 0 and 6 h after injection. The results of this analysis (in vivo biodistribution) were validated by ex vivo counting of radioactivity in dissected tissues. RESULTS: The abscess uptake (percentage of injected dose per gram of tissue [%ID/g] +/- SEM) in immunocompetent rabbits (0.41 +/- 0.05) was 10 times higher than that in neutropenic rabbits (0.038 +/- 0.014), demonstrating specificity of the target uptake of (99m)Tc-IL-8. Abscess-to-muscle ratios +/- SEM were also 10 times higher (110 +/- 10 vs. 10 +/- 5). Lung and spleen uptake in normal rabbits was 3 times higher than that in neutropenic rabbits. The blood clearance of the radiolabel in neutropenic rabbits was similar to that in normal rabbits. In circulation, most of (99m)Tc-IL-8 (70%) was found in the plasma fraction. Less than one third was associated with red blood cells, and only a very low percentage (<2.5%) was associated with white blood cells. Image analysis revealed a gradually increasing abscess uptake over time up to >15%ID, which was confirmed by ex vivo gamma-counting of the infected muscle. The highest increase in uptake in the abscess was observed after 2 h following injection, when most of (99m)Tc-IL-8 was cleared from the blood, suggesting specific neutrophil-mediated accumulation of (99m)Tc-IL-8 in the abscess. Furthermore, region-of-interest analysis revealed that gradual accumulation of (99m)Tc-IL-8 in the abscess was accompanied by a simultaneous clearance of activity from the lungs, suggesting that neutrophil-associated (99m)Tc-IL-8 that was initially trapped in the lungs migrates to the abscess at later time points, favoring neutrophil-bound transportation from the lungs to the abscess. CONCLUSION: Substantial support is given for the hypothesis that (99m)Tc-IL-8 localizes in the abscess, mainly bound to peripheral neutrophils. Accumulation in the abscess is a highly specific, neutrophil-driven process. As assessed by in vivo and ex vivo analysis, the total fraction that accumulates in the inflamed tissue is extremely high (up to >15 %ID) compared with that of other agents used for imaging infection and inflammation. 相似文献
994.
995.
996.
997.
998.
999.
Herman Van Oyen Nathalie Bossuyt Patrick Deboosere Sylvie Gadeyne Emmanuel Abatih Stefaan S. Demarest 《Sozial- und Pr?ventivmedizin》2006,51(1):67
No Abstract. .
The online version of the original article can be found at 相似文献
1000.
C. Jagger K. Ritchie H. Brnnum-Hansen D. Deeg R. Gispert J. Grimley Evans M. Hibbett B. Lawlor R. Perenboom C. Polge H. Van Oyen 《Acta psychiatrica Scandinavica》1998,98(2):85-91
The increase in life expectancy observed over the last decade has particular relevance for mental health conditions of old age, such as dementia. Although mental disorders have been estimated to be responsible for 60% of all disabilities, until recently population health indicators such as health expectancies have concentrated on calculating disability-free life expectancy based on physical functioning. In 1994, a European Network for the Calculation of Health Expectancies (Euro-REVES) was established, one of its aims being the development and promotion of mental health expectancies. Such indicators may have an important role in monitoring future changes in the mental health of populations and predicting service needs. This article summarizes the proceedings and recommendations of the first European Conference on Mental Health Expectancy. 相似文献