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61.
Purpose
We aimed to estimate the prevalence of suicidal behaviours, i.e. ideation and attempt, in the adult population of Belgium, and to explore their association with household composition.Methods
Data of 4,459 adults (25–64 years) from the 2004 Belgian Health Interview Survey were used for analyses. Bivariate and multivariate logistic regressions were used to calculate the odds of engaging in suicidal behaviours according to household type, further controlling for age, sex, income, employment status and social support.Results
Lifetime prevalence of ideation and attempts was 14 and 4.7 %, respectively. Current prevalence of ideation was 4.0 % and past year prevalence of attempts was 0.5 %. Compared to other household compositions, living alone (A) and as lone parent (P) increased the odds of lifetime and current suicidal thoughts (ORA 2.3, 95 % CI 1.7–2.9 and ORP 3.8, 95 % CI 1.9–7.7) and lifetime attempts (ORA 2.3, 95 % CI 1.4–3.6 and ORP 4.5, 95 % CI 2.4–8.5). When controlling for confounders, single person and single parent households still presented increased adjusted-odds of lifetime and current suicidal thoughts (a-ORA 1.8, 95 % CI 1.1–2.9 and a-ORP 2.3, 95 % CI 1.0–5.5). The likelihood of ever attempted suicide was also higher among single parent households (a-ORP 4.5, 95 % CI 2.4–8.5) after adjustment, but not among those living alone (a-ORA 1.4, 95 % CI 0.8–2.8).Conclusion
Living alone or as lone parent place adults at higher risk for suicide behaviour, and this is only partly explained by lower socio-economic status or poor perceived support. 相似文献62.
63.
Kim D Harrison Beverly D Hiebert Arash Panahifar Janna M Andronowski Amir M Ashique Gavin A King Terra Arnason Kurtis J Swekla Peter Pivonka David ML Cooper 《Journal of bone and mineral research》2020,35(11):2211-2228
Cortical bone porosity is intimately linked with remodeling, is of growing clinical interest, and is increasingly accessible by imaging. Thus, the potential of animal models of osteoporosis (OP) to provide a platform for studying how porosity develops and responds to interventions is tremendous. To date, rabbit models of OP have largely focused on trabecular microarchitecture or bone density; some such as ovariectomy (OVX) have uncertain efficacy and cortical porosity has not been extensively reported. Our primary objective was to characterize tibial cortical porosity in rabbit-based models of OP, including OVX, glucocorticoids (GC), and OVX + GC relative to controls (SHAM). We sought to: (i) test the hypothesis that intracortical remodeling is elevated in these models; (ii) contrast cortical remodeling and porosity in these models with that induced by parathyroid hormone (1–34; PTH); and (iii) contrast trabecular morphology in the proximal tibia across all groups. Evidence that an increase in cortical porosity occurred in all groups was observed, although this was the least robust for GC. Histomorphometric measures supported the hypothesis that remodeling rate was elevated in all groups and also revealed evidence of uncoupling of bone resorption and formation in the GC and OVX + GC groups. For trabecular bone, a pattern of loss was observed for OVX, GC, and OVX + GC groups, whereas the opposite was observed for PTH. Change in trabecular number best explained these patterns. Taken together, the findings indicated rabbit models provide a viable and varied platform for the study of OP and associated changes in cortical remodeling and porosity. Intriguingly, the evidence revealed differing effects on the cortical and trabecular envelopes for the PTH model. © 2020 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).. 相似文献
64.
Marlein Miranda Cona Yeranddy Aguiar Alpizar Junjie Li Matthias Bauwens Yuanbo Feng Ziping Sun Jian Zhang Feng Chen Karel Talavera Peter de Witte Alfons Verbruggen Raymond Oyen Yicheng Ni 《Pharmaceutical research》2014,31(2):278-290
Purpose
To study whether formulation influences biodistribution, necrosis avidity and tumoricidal effects of the radioiodinated hypericin, a necrosis avid agent for a dual-targeting anticancer radiotherapy.Methods
Iodine-123- and 131-labeled hypericin (123I-Hyp and 131I-Hyp) were prepared with Iodogen as oxidant, and formulated in dimethyl sulfoxide (DMSO)/PEG400 (polyethylene glycol 400)/water (25/60/15, v/v/v) or DMSO/saline (20:80, v/v). The formulations with excessive Hyp were optically characterized. Biodistribution, necrosis avidity and tumoricidal effects were studied in rats (n?=?42) without and with reperfused liver infarction and implanted rhabdomyosarcomas (R1). To induce tumor necrosis, R1-rats were pre-treated with a vascular disrupting agent. Magnetic resonance imaging, tissue-gamma counting, autoradiography and histology were used.Results
The two formulations differed significantly in fluorescence and precipitation. 123I-Hyp/Hyp in DMSO/PEG400/water exhibited high uptake in necrosis but lower concentration in the lung, spleen and liver (p?<?0.01). Tumor volumes of 0.9?±?0.3 cm3 with high radioactivity (3.1?±?0.3% ID/g) were detected 6 days post-treatment. By contrast, 131I-Hyp/Hypin DMSO/saline showed low uptake in necrosis but high retention in the spleen and liver (p?<?0.01). Tumor volumes reached 2.6?±?0.7 cm3 with low tracer accumulation (0.1?±?0.04%ID/g).Conclusions
The formulation of radioiodinated hypericin/hypericin appears crucial for its physical property, biodistribution, necrosis avidity and tumoricidal effects. 相似文献65.
Herman Van Oyen Bianca Cox Stefaan Demarest Patrick Deboosere Vincent Lorant 《European journal of ageing》2008,5(2):137-146
The objective is to assess if longer life in Belgium is associated with more healthy years through the evaluation of trends
(1997–2004) in health expectancy indicators at ages 65 and 80 covering different health domains: self-perceived health, chronic
morbidity, disease clusters, and disability. Information was obtained from Belgian Health Interview Surveys. Health expectancies
were calculated using the Sullivan method. Among males at age 65, the increase in years expected to live without chronic morbidity,
without a disease cluster or without disability exceeded the increase of the life expectancy (LE). The rise in LE in good
self-perceived health was equal to the gain in LE. Among women at age 65 and among men and women at age 80, none of the changes
in the expected years of life in good health in any health domain were statistically significant. At age 65 among women, the
increase in LE was smaller than the increase in years without chronic disease or without disability. The increase in years
without disease clusters was less that the LE increase. At age 80 among men, the years without disability increased as the
LE, with a shift toward years with moderate limitations. In any other health domains for men (except co-morbidity) and in
all domains for women the years in good health either decreased or increased less than the LE. The recent rise in life expectancy
in Belgium is, among the youngest old and especially among males, accompanied by an improved health status. At age 80 and
particularly among women expansion of unhealthy years prevails.
相似文献
Herman Van OyenEmail: |
66.
Auber ML; Horwitz LJ; Blaauw A; Khorana S; Tucker S; Woods T; Warmuth M; Dicke KA; McCredie KB; Spitzer G 《Blood》1988,71(1):166-172
Relatively nonmyelotoxic drugs and drug combinations were investigated for their ability to eliminate malignant cells from human bone marrow. In vitro 90% inhibitory concentration (IC90) doses were established on granulocyte macrophage colony-forming units (GM-CFU) in culture of bone marrow by using the GM-CFU assay for the following drugs: 4- hydroperoxycyclophosphamide (4-HC), Adriamycin, L-asparaginase, bleomycin, hydrocortisone, VP-16, spirogermanium, Taxol, and vincristine. The leukemic cell kill efficiency of these drugs at IC90 doses was compared with that of 4-HC on acute lymphoid leukemia (ALL) cell lines by using the limiting-dilution assay. Under these conditions, no single drug was superior to 4-HC. To increase the in vitro effect in leukemic cell kill, combinations of vincristine with hydrocortisone, Adriamycin, VP-16, and 4-HC were investigated. Vincristine at 1 to 5 micrograms/mL increased the marrow cytotoxicity of hydrocortisone, Adriamycin, and VP-16, but it was protective (subadditive) with 4-HC. Vincristine and 4-HC in combination was additive to supraadditive on ALL cell lines, increased the leukemic cell kill by one to two logs above 4-HC alone at IC90 doses (P less than .05), and was not affected by the addition of excess marrow cells. The recommended doses for chemopurging in clinical studies are vincristine, 1 to 5 micrograms/mL, plus 4-HC, 5 micrograms/mL. 相似文献
67.
van Oostenbrugge Tim J. Langenhuijsen Johan F. Oosterwijk Egbert Boerman Otto C. Jenniskens Sjoerd F. Oyen Wim J. G. Ftterer Jurgen J. Mulders Peter F. A. 《European journal of nuclear medicine and molecular imaging》2020,47(8):1864-1870
European Journal of Nuclear Medicine and Molecular Imaging - Detection of residual or recurrent vital renal tumor on follow-up (FU) cross-sectional imaging after ablative therapy is challenging.... 相似文献
68.
69.
70.
Geert Molenberghs Christel Faes Johan Verbeeck Patrick Deboosere Steven Abrams Lander Willem Jan Aerts Heidi Theeten Brecht Devleesschauwer Natalia Bustos Sierra Franoise Renard Sereina Herzog Patrick Lusyne Johan Van der Heyden Herman Van Oyen Pierre Van Damme Niel Hens 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2022,27(7)
BackgroundCOVID-19 mortality, excess mortality, deaths per million population (DPM), infection fatality ratio (IFR) and case fatality ratio (CFR) are reported and compared for many countries globally. These measures may appear objective, however, they should be interpreted with caution.AimWe examined reported COVID-19-related mortality in Belgium from 9 March 2020 to 28 June 2020, placing it against the background of excess mortality and compared the DPM and IFR between countries and within subgroups.MethodsThe relation between COVID-19-related mortality and excess mortality was evaluated by comparing COVID-19 mortality and the difference between observed and weekly average predictions of all-cause mortality. DPM were evaluated using demographic data of the Belgian population. The number of infections was estimated by a stochastic compartmental model. The IFR was estimated using a delay distribution between infection and death.ResultsIn the study period, 9,621 COVID-19-related deaths were reported, which is close to the excess mortality estimated using weekly averages (8,985 deaths). This translates to 837 DPM and an IFR of 1.5% in the general population. Both DPM and IFR increase with age and are substantially larger in the nursing home population.DiscussionDuring the first pandemic wave, Belgium had no discrepancy between COVID-19-related mortality and excess mortality. In light of this close agreement, it is useful to consider the DPM and IFR, which are both age, sex, and nursing home population-dependent. Comparison of COVID-19 mortality between countries should rather be based on excess mortality than on COVID-19-related mortality. 相似文献