Zur Kenntnis der Epithelcysten der Haut

Ohne ZusammenfassungMit 2 Textabbildungen.     

Neuritis retrobulbaris (Leber) und endokrines System

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Über den Nachweis Biologischer Wirkungen Bestrahlter Kalisalzlösungen Mittels der Schultz-Daleschen Versuchsanordnung

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THE DISTRIBUTION OF FAT IN THE LIVER

1. Nearly all livers at autopsy contain fat which is histologically demonstrable. 2. Fatty substances in the liver appear chiefly in two forms, as small granules and as globules of various sizes. 3. We suppose that granules indicate the (protoplasmic) change commonly spoken of as fatty degeneration, and that globules of small size are excess of fat, stored up by reason of some pathological change which may be merely temporary. 4. Fat is oftenest central, least often in the mid-zone. 5. A heavy deposit of fat is compatible with a competent liver. 6. Intense fattiness, generally globular, occurs with intoxications of bacterial and chemical nature, as well as in cases where a complex toxin is manufactured by the body-cells. 7. Granular fat occurs oftener than globular: it affects most often the central zone; globular affects most often the peripheral. 8. " Accidental " masses of globular fat are found at times, and appear to follow no rule of position: these are comparable to lipomata, which are evidently the result of a pathological process. 9. We found no deposit of fat characteristic of uremia. 10 We know of no analysis of the liver fats in the granular and globular states respectively: it seems to have been taken for granted that the deposits were one and the same. To determine the relationship, if any, between these two forms should be the basis of investigation.     

Vascular endothelial growth factor in thyroid cyst fluids

BACKGROUND: The pathogenesis of cystic thyroid nodules is incompletely understood. Based on the assumption that vascular endothelial growth factor (VEGF) may play an important role in the pathogenesis of thyroid cyst fluid, we investigated the VEGF concentration in cyst fluids of thyroid lesions. DESIGN: Cyst fluids from 24 patients (age 31-84 years) were obtained using ultrasound-guided fine-needle aspiration. The patients' cystic thyroid nodules were of different origins. METHODS: Thyroid and cyst volumes were determined using high-resolution ultrasonography. VEGF concentrations were determined using a solid-phase enzyme-linked immunosorbent assay (ELISA). RESULTS: Differing elevated VEGF concentrations were demonstrated in cyst fluids of thyroid nodules of varied origins. The VEGF concentration in cyst fluid of patients with adenomatous goiter was significantly higher (P < 0.05) than that in thyroid nodules with cystic degeneration. The highest level of VEGF was found in bloody cyst fluid when compared with levels in other cyst fluids (P < 0.05). Interestingly, there was significant correlation (P < 0.01) between thyroid volume and VEGF concentration in cyst fluid, but no significant correlation (P = 0.20) between cyst volume and VEGF concentration. CONCLUSION: Significantly increased VEGF concentrations were found in bloody cyst fluid and in cyst fluid of thyroid adenomatous goiter, compared with VEGF concentrations in degenerative thyroid cysts. Our results suggest that VEGF may play an important role in the pathogenesis of thyroid cyst fluid.