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BACKGROUND: Recently, it was shown that fat tissue produces and releases inflammatory cytokines, and that obesity may be regarded as a state of low-grade inflammation. In this regard, we aimed to establish an association between obesity and persistent leukocytosis. PATIENTS AND METHODS: We present clinical observations of obese subjects primarily referred for further evaluation of leukocytosis without a cause and validated the link between leukocytosis and elevated body mass index (BMI) in a cross-sectional study. RESULTS: During 1999-2005, 327 patients were referred for further investigation because of persistent leukocytosis. Of these, 15.3% were asymptomatic obese, mostly females, with mild persistent neutrophilia accompanied by elevated acute-phase reactants. After careful evaluation, no recognized cause for leukocytosis was found other than the fact that the patients were obese. During a mean follow-up of 45.6 months, the leukocytosis and the elevated acute-phase reactants persisted and no new causes for leukocytosis were evident. Furthermore, in a cross-sectional analysis of 3716 non-smoker subjects, 62 were found to have leukocytosis. Compared with the population with a normal white blood count range, these subjects with leukocytosis had higher BMI, serum C-reactive protein (CRP) levels, waist circumference, and neutrophil and platelet count (all P < 0.0005). After logistic regression analysis, only BMI was shown to be associated with leukocytosis (P < 0.0005). CONCLUSIONS: Obesity is recognized as a possible cause for reactive leukocytosis. Awareness of this 'obesity-associated leukocytosis' may help the clinician to avoid more extensive and unnecessary diagnostic work-up, particularly in similar obese subjects. 相似文献
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Anat Gafter-Gvili Michal Herman Yaacov Ori Asher Korzets Avry Chagnac Boris Zingerman Benaya Rozen-Zvi Uzi Gafter Tsipora Malachi 《Leukemia research》2011,35(2):219-225
Background
Mitochondria provide ATP and Ca2+ needed for DNA repair, but also produce reactive oxygen species (ROS), which may damage DNA.Aim
To investigate the effect of mitochondrial function inhibition on DNA repair.Method
Five mitochondrial inhibitors acting at various sites of electron transport were studied. Human peripheral blood mononuclear cells, spontaneous and H2O2-indcued DNA repair, as well as %-double-stranded-DNA, were measured.Results
All mitochondrial inhibitors suppressed spontaneous and H2O2-induced DNA repair. However, their effect on %-double-stranded-DNA differed, which is partly related to ROS suppression.Conclusion
Mitochondrial inhibition may enhance efficacy and reduce toxicity of radiation and cytotoxic drugs therapy. 相似文献997.
K B Schechtman B Barzilai K Rost E B Fisher Jr 《American journal of public health》1991,81(6):771-773
Using 1,004 subjects enrolled in a worksite health promotion program, this report evaluated the validity of a single question about participation in regular exercise. Measured at baseline, this one question had a significant age-adjusted association with body mass index (p less than 0.0001 in women and p = 0.001 in men), HDL cholesterol (p less than 0.0001 in women), and oxygen capacity (p = 0.0007 in women and p = 0.002 in men). Thus, one self-reported question can provide useful information about who is and who is not participating in regular exercise. The potential validity of a single exercise question is particularly relevant in complex epidemiologic studies where lengthy questionnaires highlight the importance of brief instruments. 相似文献
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Paran D Caspi D Levartovsky D Elkayam O Kaufman I Litinsky I Keren G Koifman B 《Annals of the rheumatic diseases》2007,66(4):506-510
OBJECTIVE: To comparatively assess the parameters of systolic and diastolic cardiac function in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). METHODS: Consecutive patients (n=74) who were free of cardiovascular symptoms were divided into four groups: (1) SLE (n=23); (2) SLE with antiphospholipid antibodies (aPL; n=18); (3) SLE with APS (n=20); and (4) primary antiphospholipid syndrome (PAPS; n=13). Pulsed, continuous, colour Doppler echocardiography, and M-mode and B-mode studies were performed. RESULTS: Left ventricular end diastolic and end systolic dimensions were higher in SLE as compared with patients with PAPS (p=0.022 and 0.022, respectively), with a trend towards a lower fractional shortening in SLE (p=0.07), suggesting systolic dysfunction. Parameters of diastolic function were more impaired in patients with APS, reflected by lower left ventricular and right ventricular E wave to A wave (E:A) ratios in patients with APS (groups 3, 4) compared with those without APS (groups 1, 2; 1.15 (0.40) v 1.49 (0.43), p=0.001 and 1.19 (0.31) v 1.49 (0.41), p=0.001, respectively) and a more prolonged left ventricular isovolumic relaxation time (IVRT; 94.2 (24.6) v 84.4 (17) ms, respectively, p=0.055). Patients with APS were older than those without APS (47.12 (14.86) v 34.29 (12.6), p=0.0001). Patients with SLE were younger than those with PAPS (38.19 (14.68) v 48.53 (13.97), p=0.023). CONCLUSION: Abnormal echocardiographic findings were detected frequently in asymptomatic patients with SLE or PAPS. Although patients with SLE were younger, left ventricular systolic function was more impaired in patients with SLE compared with those with PAPS, whereas left ventricular and right ventricular diastolic function, as reflected by IVRT and E:A ratios, were significantly more impaired in patients with APS. 相似文献
999.
Harris KM Petrovic O Dávila-Román VG Yusen RD Littenberg B Barzilai B 《Echocardiography (Mount Kisco, N.Y.)》1999,16(6):559-565
Since its advent, the use of transesophageal echocardiography (TEE) has grown rapidly. In patients undergoing TEE in the intensive care unit over two time periods (4 years apart), we evaluated whether TEE led to new/unsuspected findings or changes in patient management. Results showed that the indications for which patients underwent TEE changed considerably between the two time periods. Hemodynamic instability was an indication for TEE in 41% of the patients in the first interval and 56% of the patients in the second interval. TEE frequently established a new diagnosis (41%) and led to significant management changes (28%) in both time periods. These changes occurred despite the use of a pulmonary artery catheter in nearly 2/3 of the patients studied. Therefore, despite increasing and changing use, TEE frequently establishes unsuspected diagnosis and directly influences patient management when used in intensive care patients. 相似文献
1000.
Toker Ori Broides Arnon Lev Atar Simon Amos J. Megged Orli Shamriz Oded Tal Yuval Somech Raz Lee Yu Nee Nahum Amit 《Immunologic research》2022,70(2):216-223
Immunologic Research - X-linked agammaglobulinemia (XLA) is caused by mutations in the Bruton tyrosine kinase) BTK) gene. Affected patients have severely reduced amounts of circulating B cells.... 相似文献