全文获取类型
收费全文 | 2121篇 |
免费 | 112篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 65篇 |
妇产科学 | 64篇 |
基础医学 | 221篇 |
口腔科学 | 16篇 |
临床医学 | 163篇 |
内科学 | 525篇 |
皮肤病学 | 11篇 |
神经病学 | 198篇 |
特种医学 | 155篇 |
外科学 | 227篇 |
综合类 | 12篇 |
一般理论 | 2篇 |
预防医学 | 82篇 |
眼科学 | 7篇 |
药学 | 205篇 |
中国医学 | 14篇 |
肿瘤学 | 264篇 |
出版年
2023年 | 11篇 |
2022年 | 38篇 |
2021年 | 34篇 |
2020年 | 36篇 |
2019年 | 51篇 |
2018年 | 57篇 |
2017年 | 37篇 |
2016年 | 29篇 |
2015年 | 54篇 |
2014年 | 72篇 |
2013年 | 78篇 |
2012年 | 152篇 |
2011年 | 163篇 |
2010年 | 89篇 |
2009年 | 73篇 |
2008年 | 109篇 |
2007年 | 103篇 |
2006年 | 103篇 |
2005年 | 90篇 |
2004年 | 115篇 |
2003年 | 86篇 |
2002年 | 83篇 |
2001年 | 49篇 |
2000年 | 65篇 |
1999年 | 37篇 |
1998年 | 22篇 |
1997年 | 16篇 |
1996年 | 16篇 |
1995年 | 20篇 |
1994年 | 15篇 |
1993年 | 14篇 |
1992年 | 29篇 |
1991年 | 26篇 |
1990年 | 33篇 |
1989年 | 21篇 |
1988年 | 24篇 |
1987年 | 13篇 |
1986年 | 16篇 |
1985年 | 16篇 |
1984年 | 18篇 |
1983年 | 12篇 |
1982年 | 7篇 |
1980年 | 9篇 |
1979年 | 12篇 |
1976年 | 7篇 |
1975年 | 10篇 |
1974年 | 10篇 |
1973年 | 6篇 |
1969年 | 6篇 |
1967年 | 6篇 |
排序方式: 共有2239条查询结果,搜索用时 31 毫秒
41.
Predictors of cognitive improvement after reality orientation in Alzheimer's disease 总被引:1,自引:0,他引:1
Zanetti O Oriani M Geroldi C Binetti G Frisoni GB Di Giovanni G De Vreese LP 《Age and ageing》2002,31(3):193-196
BACKGROUND: there is increasing evidence to support the efficacy of reality orientation in cognitive deficits in patients with Alzheimer's disease. The clinical characteristics of patients who respond to reality orientation are poorly understood; this knowledge could be important, given that the provision of reality orientation therapy is labour-intensive and may provoke emotional distress. AIM: to evaluate retrospectively which demographic and clinical characteristics of Alzheimer's patients predict cognitive outcomes. METHOD: we analysed 38 mild-to-moderately demented outpatients who regularly attended a one-month formal reality orientation programme. The mini mental state examination score changes from baseline-and immediately after-reality orientation were correlated with demographic and pre-treatment clinical characteristics by a linear regression analysis. RESULTS: short-term responsiveness to reality orientation was significantly predicted by a lower level of cognitive functioning (as measured by the mini mental state examination) at baseline and by the absence of euphoria, accounting together for 57.6% of variance. CONCLUSION: a lower mini mental state examination and the absence of euphoric behaviour in patients with mild-to-moderate Alzheimer's disease may predict a good cognitive outcome of reality orientation therapy. 相似文献
42.
43.
Gagliardi Federica Lauro Augusto Tripodi Domenico Amabile Maria Ida Palumbo Piergaspare Di Matteo Filippo Maria Palazzini Giorgio Forte Flavio Frattaroli Stefano Khouzam Simone Marino Ignazio R. DAndrea Vito Sorrenti Salvatore Pironi Daniele 《Digestive diseases and sciences》2022,67(3):786-798
Digestive Diseases and Sciences - Mesenteric cysts are defined as a heterogeneous group of intra-abdominal cystic lesions of the mesentery or omentum that may be found in any portion of the... 相似文献
44.
Russo Vincenzo Bottino Roberta D’Andrea Antonello Silverio Angelo Di Maio Marco Golino Paolo Nigro Gerardo Valsecchi Orazio Attena Emilio Canonico Mario Enrico Galasso Gennaro Parodi Guido Scudiero Fernando 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2022,36(4):705-712
Cardiovascular Drugs and Therapy - The clinical course of COVID-19 may be complicated by acute respiratory distress syndrome (ARDS) and thromboembolic events, which are associated with high risk of... 相似文献
45.
Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells 总被引:39,自引:6,他引:39
Detailed studies of tumor cell-associated procoagulants and fibrinolytic factors have implied that local thrombin generation and fibrin deposition and dissolution may be important in tumor growth and dissemination. To directly determine whether fibrin(ogen) or plasmin(ogen) are determinants of the metastatic potential of circulating tumor cells, this study examined the impact of genetic deficits in each of these key hemostatic factors on the hematogenous pulmonary metastasis of 2 established murine tumors, Lewis lung carcinoma and the B16-BL6 melanoma. In both tumor models, fibrinogen deficiency strongly diminished, but did not prevent, the development of lung metastasis. The quantitative reduction in metastasis in fibrinogen-deficient mice was not due to any appreciable difference in tumor stroma formation or tumor growth. Rather, tumor cell fate studies indicated an important role for fibrin(ogen) in sustained adhesion and survival of tumor cells within the lung. The specific thrombin inhibitor, hirudin, further diminished the metastatic potential of circulating tumor cells in fibrinogen-deficient mice, although the inhibitor had no apparent effect on tumor cell proliferation in vitro. The absence of plasminogen and plasmin-mediated fibrinolysis had no significant impact on hematogenous metastasis. The authors concluded that fibrin(ogen) is a critical determinant of the metastatic potential of circulating tumor cells. Furthermore, thrombin appears to facilitate tumor dissemination through at least one fibrin(ogen)-independent mechanism. These findings suggest that therapeutic strategies focusing on multiple distinct hemostatic factors might be beneficial in the containment of tumor metastasis. 相似文献
46.
47.
G. Frieri M. Pimpo B. Galletti G. Palumbo G. Corrao G. Latella M. Chiaramonte R. Caprilli 《Digestive and liver disease》2005,37(2):92-96
BACKGROUND: In cross-sectional studies, it was demonstrated that the therapeutic effect of mesalazine is closely related to its mucosal concentration. AIM: This study was carried out to verify in a longitudinal study if it was possible to improve the clinical course of ulcerative colitis at high risk of recurrence by increasing mucosal mesalazine concentration. METHODS: Eighteen consecutive ulcerative colitis patients on continuous oral 5-ASA treatment (2.4-3.2 g/day) in clinical remission who had had at least four moderate to severe relapses in the preceding 2 years (referred period) were assigned to assume oral (3.2-4.8 g/day) and topical (4 g/day) mesalazine in order to increase mucosal drug concentration and were followed up for 2 years (study period). The localisation of disease was 12 pancolitis, six left colitis. The number and severity of recurrences, number of visits and endoscopies, courses of steroids and days of hospitalisation were compared with those of the previous 2 years. Rank signed test for paired data was used for statistical analysis. RESULTS: The total number of recurrences was significantly lower during the study period in comparison with that of referred period (8 versus 80, respectively, p < 0.0001). No courses of steroids or hospitalisation were necessary during study period in comparison with those of referred period (0 versus 33, p < 0.0001; 0 versus 93, p = 0.03, respectively). A total number of 249 visits were done during the referred period and 116 during the study period (p < 0.0001) with a total of 87 endoscopies during referred period and 44 during study period (p < 0.0001). CONCLUSIONS: The continuous use of topical mesalazine associated with a high oral dosage significantly improves the clinical course of ulcerative colitis patients at high risk of relapse. 相似文献
48.
In six healthy subjects serum oestradiol was selectively decreased by administering an aromatase activity inhibitor, hydrotestolactone (HT). After HT administration serum oestradiol (Oe2) decreased from 18.7 +/- 2.3 (SEM) to 6.7 +/- 0.6 pg/ml whereas testosterone (T) and dihydrotestosterone (DHT) blood levels were not modified. These oestradiol changes were associated with a significant increase in serum LH and FSH concentrations (P less than 0.001). The administration of tamoxifen, an oestrogen antagonist, to 5 subjects caused a sharp increase in LH and FSH levels (P less than 0.001). Oe2 was unchanged after the treatment with tamoxifen, whereas T levels were significantly higher. The sum of these data suggests that oestradiol under physiological conditions plays a specific role in the feedback mechanism of gonadotrophin release. 相似文献
49.
Latiano A Palmieri O Valvano MR D'Incà R Cucchiara S Riegler G Staiano AM Ardizzone S Accomando S de Angelis GL Corritore G Bossa F Annese V 《World journal of gastroenterology : WJG》2008,14(29):4643-4651
AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age 〈 19 years), 843 with ulcerative colitis (UC, 179 diagnosed 〈19 years), 749 healthy controls, and 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381Gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P 〈 0.01), compared with controls (6% and 38%, respectively). The A allele (but not G) was also reduced signifi cantly in UC (4%, OR = 0.69, CI = 0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARD15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population. 相似文献
50.
Subpopulation heterogeneity in human acute myeloid leukemia determined by monoclonal antibodies 总被引:2,自引:0,他引:2
S Pessano A Palumbo D Ferrero G L Pagliardi L Bottero S K Lai P Meo C Carter H Hubbell B Lange 《Blood》1984,64(1):275-281
The leukemic population in 63 patients with acute myeloid leukemia (AML) was studied with 15 monoclonal antibodies that detect lineage-related and stage-related antigens on normal hemopoietic cells. Indirect immunofluorescence and fluorescence-activated cell sorting showed that subpopulations of leukemic cells reacted with some or all antibodies, but the percentage of cells reacting with a single antibody varied widely among patients. The composite antigenic phenotype of the various cases, as determined by immunofluorescence assay, did not correlate with the French-American-British morphological classification. Furthermore, some cells in each case failed to express any antigen normally expressed on myelomonocytic precursors from the level of the early CFU-GM to the mature granulocyte or monocyte. In double-fluorescence experiments, the individual cells expressed none, one, or both antigens. These results demonstrate that there is considerable subpopulation heterogeneity in AML. This heterogeneity may considerably limit or complicate the use of monoclonal antibodies for diagnosis, prognosis, and treatment of acute nonlymphocytic leukemia (ANLL). 相似文献