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101.
Resolution of acyclovir‐associated neurotoxicity with the aid of improved clearance estimates using a Bayesian approach: A case report and review of the literature 下载免费PDF全文
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To determine the preferred investigation of congenital vascular compression of the trachea, preoperative investigation in 40 patients undergoing surgery 1981-91 was analysed. The importance of preoperative identification of detailed arterial anatomy in determining surgical technique was also assessed in 122 consecutive patients undergoing surgery 1952-91. Of the 40 patients (median age 5 months) seen 1981-91, barium swallow before referral suggested the diagnosis of vascular compression in 26 of 27 (96%). Angiography (1/3), bronchoscopy (0/6), and echocardiography (2/6) were generally unhelpful in diagnosing vascular compression before referral. Echocardiography was performed after referral in 18 consecutive patients since 1986 and the correct arterial anatomy was identified in 16 (88%); hyperinflation resulted in inadequate images in the two others. Barium swallow is the investigation of choice to screen for suspected vascular compression of the trachea; echocardiography at the referral centre can define the arterial anatomy in nearly all patients. Further investigation can be reserved for selected cases. 相似文献
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Medullary thyroid carcinoma: role of high-resolution US 总被引:2,自引:0,他引:2
Gorman B; Charboneau JW; James EM; Reading CC; Wold LE; Grant CS; Gharib H; Hay ID 《Radiology》1987,162(1):147
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MR cholangiography: clinical evaluation in 40 cases 总被引:15,自引:0,他引:15
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Oliver?GraupnerEmail authorView authors OrcID profile Silvia?M.?Lobmaier Javier?U.?Ortiz Anne?Karge Bettina?Kuschel 《Archives of gynecology and obstetrics》2018,298(3):567-577
Purpose
The soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio has been shown to be a useful parameter for the diagnosis and prediction of preeclampsia (PE). An increased sFlt-1/PlGF ratio can be closely linked to the need to deliver. The aim of the study was to examine the mean time until delivery (MTUD) in pregnant women with a strongly increased sFlt-1/PlGF ratio.Methods
From 2010 to 2018, the sFlt-1/PlGF ratio was determined in 995 singleton pregnancies with diagnosis or suspicion of PE/HELLP syndrome and/or intrauterine growth restriction (IUGR). MTUD of patients with a value above 655 in?<?34 weeks of gestation (group 1: n?=?13) and above 201 in?≥?34 weeks of gestation (group 2: n?=?15) was calculated. Patients with a value?>?85 but?<?655 in?<?34 weeks of gestation (group 3: n?=?70) and a value?>?110 but?<?201 (group 4: n?=?44) in?≥?34 weeks of gestation acted as controls.Results
28 pregnant women with severely elevated sFlt-1/PlGF ratio and 114 controls were included. In group 1, MTUD was longer compared to group 2 without reaching statistical significance (96.7 h?±?132.2 vs. 47.7 h?±?44, p?=?0.222). In pregnancies?<?34 weeks of gestation (early onset), MTUD was significantly longer in group 3 compared to group 1 (361 h?±?317.3 vs. 96.7 h?±?132.2, p?<?0.001). In pregnancies?≥?34 weeks of gestation (late onset), MTUD was significantly longer in group 4 compared to group 2 (123.6 h?±?139.2 vs. 47.7 h?±?44, p?=?0.002).Conclusions
The sFlt-1/PlGF ratio is suitable for decision-making regarding close monitoring of high-risk patients and need for lung maturation. However, for planning of delivery itself further prospective interventional studies are required to define its role as outcome predictor.109.
Monoclonal antibody 7.1, which recognizes the chondroitin sulfate proteoglycan molecule NG2, was used to screen prospectively blast cells from 104 consecutive children at initial presentation with acute lymphoblastic leukemia (ALL). Reactivity with this antibody was found in 9 cases (8.6%), of whom 5 had a t(4;11)(q21;q23) and 4 had a t(11;19)(p13;q23). None of the NG2- cases had either translocation. Southern blot analysis disclosed MLL gene rearrangement in only the 9 cases with 7.1 reactivity plus the t(4;11)(q21;q23) or t(11;19)(q23;p13) translocation. MLL gene rearrangements were not detected in 89 patient leukemic samples that did not express NG2, including 7 patients with del(11)(q23) or inv(11)(p13q23). As expected from the association with t(4;11) and t(11;19), NG2+ cases were significantly more likely to be infants, to have hyperleukocytosis and central nervous system involvement, to be CD10-, and to express myeloid- associated antigens CD15 and CD65. Despite short follow-up duration, 3 of the NG2+ cases have relapsed while the other 101 patients remain in remission. Thus, blast cell surface expression of NG2 is useful for identifying patients with ALL having t(4;11) or t(11;19) translocations that are associated with poor prognosis, especially in the infant age group. 相似文献
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Alcohol and substance use portrayals in Nigerian video tapes: an analysis of 479 films and implications for public drug education 总被引:1,自引:0,他引:1
There is an observed increasing trend of substance use among the adolescents and young adults. One of the important aetiologies is "modeling" especially from popular artists portraying their use to the viewing public over the electronic media. Indigenous films on video tapes acted in English or "Yoruba" (a popular Nigerian language) were randomly selected from various retail outlets in Lagos for viewing. The settings were the Ikorodu and Ipaja suburbs of Lagos. The viewing audience in each center was made up of a researcher and two adolescent secondary school students. They were to make notes on each film with scenes of substance use, type, and nature of use. A total of 479 video tapes were studied over a 6 month period, of which 268 (55.9%) contained scenes portraying the use of one or more substances. Two hundred forty-seven (51.6%, N = 479) depicted the use of only one type of substance and the rest, 21 (4.3%, N = 479), portrayed the use of multiple substances. The commonest substance portrayed to be used was alcohol, 197 (41.1%, N = 479), followed by tobacco, 81 (16.9%, N = 479). Cannabis was shown to be used in only 3 (0.6%, N = 479); Cocaine and Heroin in 8 (1.6%, N = 479) of the films. There was no statistically significant difference on substance use portrayal between the home movies acted in English and Yoruba (chi2 = 32.8; df = 7 at p > or = 0.05). A significant number of films on video tapes in Nigeria portrayed substance use which could act as triggers or reinforcement for substance use among the viewing audience, especially adolescents and young adults. The need to censor video tapes on substance use portrayal was advocated. 相似文献