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Reference Values for Echocardiography in Middle‐Aged Population: The Cardiovascular Risk in Young Finns Study
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Saku Ruohonen Ph.D Juha W. Koskenvuo M.D. Ph.D. Maria Wendelin‐Saarenhovi M.D. Ph.D. Mikko Savontaus M.D. Ph.D. Mika Kähönen M.D. Ph.D. Tomi Laitinen M.D. Ph.D. Terho Lehtimäki M.D. Ph.D. Eero Jokinen M.D. Ph.D. Jorma Viikari M.D. Ph.D. Markus Juonala M.D. Ph.D. Leena Taittonen M.D. Ph.D. Päivi Tossavainen M.D. Ph.D. Merja Kallio M.D. Ph.D. Jeroen J. Bax M.D. Ph.D. Olli Raitakari M.D. Ph.D. 《Echocardiography (Mount Kisco, N.Y.)》2016,33(2):193-206
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Emily W. Harville Markus Juonala Jorma S. A. Viikari Olli T. Raitakari 《Gynecological endocrinology》2014,30(11):840-844
Pregnancy conditions such as gestational diabetes (GDM) and macrosomia lead to an increased risk of diabetes and cardiovascular disease in the offspring, perpetuating a cycle of poor health. We hypothesized that (1) pre-pregnancy indicators of metabolism would be associated with GDM and birthweight; and (2) the lipid accumulation product (LAP; incorporating waist circumference and triglycerides) and visceral adiposity index (VAI; incorporating waist circumference, triglycerides, and HDL-c) would be better predictors of GDM and birthweight than other indicators. Data from the Cardiovascular Risk in Young Finns Study were linked to the Finnish birth registry for 349 women. BMI, triglycerides, waist circumference, insulin, HOMA-IR, LAP, and VAI at the visit prior to the pregnancy were examined as predictors of GDM and large-for-gestational-age (LGA) using logistic regression with adjustment for age, parity, and smoking. Waist circumference was the strongest predictor of GDM (adjusted odds ratio [aOR] 1.66, 95% confidence interval 1.16–2.38) and LGA (aOR 1.41, 1.00–1.99). For GDM, all markers had similar discrimination; for LGA, the area under the receiver operating curve for waist circumference was significantly higher than for BMI (p?0.01). This analysis suggests that pregnancy and even offspring health is affected by risk factors outside the immediate time period of pregnancy. 相似文献
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Rissanen TT Korpisalo P Markkanen JE Liimatainen T Ordén MR Kholová I de Goede A Heikura T Gröhn OH Ylä-Herttuala S 《Circulation》2005,112(25):3937-3946
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Ungureanu D Vanhatupa S Kotaja N Yang J Aittomaki S Jänne OA Palvimo JJ Silvennoinen O 《Blood》2003,102(9):3311-3313
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Increased carotid atherosclerosis in andropausal middle-aged men 总被引:2,自引:0,他引:2
Mäkinen J Järvisalo MJ Pöllänen P Perheentupa A Irjala K Koskenvuo M Mäkinen J Huhtaniemi I Raitakari OT 《Journal of the American College of Cardiology》2005,45(10):1603-1608
OBJECTIVES: This study examined the association between carotid artery intima-media thickness (IMT), serum sex hormone levels, and andropausal symptoms in middle-aged men. BACKGROUND: Male sex hormones may play a dual role in the pathogenesis of atherosclerosis in men by carrying both proatherogenic and atheroprotective effects. METHODS: We studied 239 40- to 70-year-old men (mean +/- SD: 57 +/- 8 years) who participated in the Turku Aging Male Study and underwent serum lipid and sex hormone measurements. Ninety-nine men (age 58 +/- 7 years) were considered andropausal (i.e., serum testosterone <9.8 nmol/l or luteinizing hormone [LH] >6.0 U/l and testosterone in the normal range), and in both situations, they had subjective symptoms of andropause (a high symptom score in questionnaire). Three were excluded because of diabetes. The rest of the men (age 57 +/- 8 years) served as controls. Carotid IMT was determined using high-resolution B-mode ultrasound, and serum testosterone, estradiol (E2), LH, and sex hormone-binding globulin were measured using standard immunoassays. RESULTS: Andropausal men had a higher maximal IMT compared with controls in the common carotid (1.08 +/- 0.34 vs. 1.00 +/- 0.23, p < 0.05) and in the carotid bulb (1.44 +/- 0.48 vs. 1.27 +/- 0.35, p = 0.003). Common carotid IMT correlated inversely with serum testosterone (p = 0.003) and directly with LH (p = 0.006) in multivariate models adjusted for age, total cholesterol, body mass index, blood pressure, and smoking. CONCLUSIONS: Middle-aged men with symptoms of andropause, together with absolute or compensated (as reflected by high normal to elevated LH) testosterone deficiency, show increased carotid IMT. These data suggest that normal testosterone levels may offer protection against the development of atherosclerosis in middle-aged men. 相似文献
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Päivä H Laakso J Laine H Laaksonen R Knuuti J Raitakari OT 《Journal of the American College of Cardiology》2002,40(7):1241-1247
OBJECTIVE: The goal of this study was to examine the relationship between plasma asymmetric dimethylarginine (ADMA) level and hyperemic myocardial blood flow (MBF) in subjects with borderline hypertension (BHT) and familial hypercholesterolemia (FH). METHODS: Asymmetric dimethylarginine is an endogenous competitive inhibitor of nitric oxide synthase that may modulate vascular function.We measured plasma ADMA levels and myocardial flow in 77 young men (mean age 35 +/- 5 years), including 47 healthy controls, 16 men with BHT, and 14 men with FH. Basal and dipyridamole-induced myocardial flow was measured using positron emission tomography. Plasma ADMA levels were measured using high-pressure liquid chromatography. RESULTS: Asymmetric dimethylarginine levels were significantly elevated in the BHT group compared with controls (0.59 +/- 0.13 micromol/l vs. 0.43 +/- 0.12 micromol/l, p < 0.001), and they had significantly lower dipyridamole flow (2.85 +/- 1.20 ml/min/g vs. 3.69 +/- 1.68 ml/min/g, p < 0.05). In a multivariate regression model adjusted for the study group, dipyridamole flow was inversely associated with ADMA (p < 0.05), age (p < 0.05), and apolipoprotein B concentration (p < 0.05). CONCLUSIONS: We conclude that plasma ADMA concentration is related to dipyridamole-induced vasodilatory function in young men, independently of blood pressure elevation and hypercholesterolemia. Subjects with BHT have significantly increased plasma ADMA levels, which may partly explain the impaired hyperemic MBF in this condition. 相似文献
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Tom Rosenström Markus Jokela Mirka Hintsanen Kim Josefsson Markus Juonala Mika Kivimäki Laura Pulkki-Råback Jorma S.A. Viikari Nina Hutri-Kähönen Erkki Heinonen Olli T. Raitakari Liisa Keltikangas-Järvinen 《Journal of affective disorders》2013