全文获取类型
收费全文 | 310篇 |
免费 | 14篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 4篇 |
妇产科学 | 1篇 |
基础医学 | 50篇 |
临床医学 | 28篇 |
内科学 | 35篇 |
皮肤病学 | 12篇 |
神经病学 | 20篇 |
特种医学 | 1篇 |
外科学 | 32篇 |
综合类 | 1篇 |
预防医学 | 107篇 |
眼科学 | 3篇 |
药学 | 12篇 |
中国医学 | 1篇 |
肿瘤学 | 14篇 |
出版年
2024年 | 1篇 |
2023年 | 8篇 |
2022年 | 14篇 |
2021年 | 14篇 |
2020年 | 3篇 |
2019年 | 15篇 |
2018年 | 17篇 |
2017年 | 5篇 |
2016年 | 8篇 |
2015年 | 10篇 |
2014年 | 12篇 |
2013年 | 14篇 |
2012年 | 30篇 |
2011年 | 29篇 |
2010年 | 27篇 |
2009年 | 13篇 |
2008年 | 17篇 |
2007年 | 19篇 |
2006年 | 15篇 |
2005年 | 15篇 |
2004年 | 12篇 |
2003年 | 15篇 |
2002年 | 11篇 |
排序方式: 共有324条查询结果,搜索用时 15 毫秒
41.
11 beta-hydroxylase deficiency is a rare recessive autosomal disorder. The aim of this report was to describe among a retrospective study of seven cases, different clinical pictures, problems in diagnosis and management. Results: the frequency of 11 beta-hydroxylase deficiency was 17.5% of congenital adrenal hypererplasia etiology in our study. Consanguinity was found in all cases. The sex ratio was 5 boys/2 girls. Median age on diagnosis was 4.3 years. Five cases were revealed with precocious puberty associated with hypertension. One patient had sexual ambiguity, Prader IV stage, hypertension appears later. One patient developed heterosexual precocious puberty and hypertension at five years of age. One patient had bilateral testicular adrenal rests. Hypertension was diagnosed early in 4 cases and secondarly in the other 3 cases. Hypertension was severe complicated by convulsions, facial paralysis and epistaxis. Hypo kaliemia was identified in six cases. Hormonal investigations confirmed diagnosis in all cases. The secondary sexual characteristics were controled by glucocorticoid substitution. Antihypertensive treatment was necessary initially and prolonged only in three cases. Prognosis of final height of patients with late diagnosis was particularly compromised. 相似文献
42.
Ayadi-Kaddour A Abid L Braham E Saïji E Ismail O Smati B Kilani T El Mezni F 《La Tunisie médicale》2006,84(3):205-208
Inflammatory pseudotumors are uncommon benign lesions of the lung of unknown origin, that may show aggressive behavior. Although pseudotumors constitute less than 1% of all lung tumors, they are reported to be the most common cause of solitary lung masses in children. Complete resection, when possible, is safe and leads to excellent survival. The case presented here highlights difficulties in clinical and histologic diagnosis. 相似文献
43.
Rim Ouneissa Olfa Bahri Nissaf Ben Alaya‐Bouafif Sofiene Chouaieb Ahlem Ben Yahia Amel Sadraoui Walid Hammami Noureddine Filali Mohamed Msaddak Azzouz Nabyl Ben Mami Henda Triki 《Journal of medical virology》2012,84(11):1719-1726
Genetic variability of hepatitis B virus (HBV) in the C gene and its association with the different stages of chronic liver disease has been studied inadequately with controversial results. The objectives of the current study were to determine the frequency of core promoter and precore mutations in chronic hepatitis B in Tunisia and to evaluate their impact on viral replication and disease progression. Sequencing was performed in upstream regulatory sequence (URS), pre‐core (PreC) and basal core promoter (BCP) regions for 123 chronic infected patients by HBV genotype D at different status of disease. Mutations were detected in 98.4% of cases, affecting URS, BCP and Pre‐C in 95.1%, 95.9% and 87.8% respectively. Multi‐mutations increased significantly from asymptomatic carrier to advanced liver disease status. G1896A (74.8%), G1764A/T/C (71.5%), G1899A (54.4%) and T1678C (52%) were the most common. Special attention should be paid to A1703T, T1678C/G‐A1703T, and A1652G‐A1679G mutations probably specific of Tunisians sequences; they were observed in 40.6%, 41.5% and 30.1% respectively. A1679G/C, T1753C/G/A, A1762T/G and A1762T‐G1764A were more prevalent in older patients. High DNA levels were associated with G1899A or G1764T/C‐C1766G‐C1799G and advanced liver disease with mutations at positions 1762, 1764 and/or 1899 alone or in double or triple mutations. It was also shown that substitutions at nucleotides 1762, 1764 and 1899 have an impact on the disease progression. It is the first report for specific mutations in the URS region for genotype D. It should be completed by studying eventual correlation with clinical progression and the response to treatment. J. Med. Virol. 84:1719–1726, 2012. © 2012 Wiley Periodicals, Inc. 相似文献
44.
Chaabane NB Mansour IB Hellara O Loghmeri H Bdioui F Safer L Saffar H 《Presse medicale (Paris, France : 1983)》2011,40(3):239-247
Anemia induced by digestive diseases refers to anemia due to iron deficiency. Conventional gastrointestinal diagnostic workup fails to establish the cause of iron deficiency in about one third of patients. Abnormal iron absorption is increasingly recognized as an important cause of unexplained iron deficiency. The importance of coeliac disease as a possible cause of iron deficiency anemia refractory to oral iron treatment, without other manifestations of malabsorption syndrome, is increasingly being recognized. In addition, Helicobacter pylori (HP) has been implicated in several recent studies as a cause of iron deficiency anemia (IDA) refractory to oral iron treatment. Cure of previously refractory IDA by HP eradication provides strong evidence supporting a cause-and-effect relationship. In order to establish a cause-and-effect relationship between HP gastritis and IDA, prospective randomized studies comparing the effects of iron administration with or without H. pylorieradication are highly recommended. 相似文献
45.
Ines Omrane Olfa Baroudi Nadia Kourda Yves-Jean Bignon Nancy Uhrhammer Alexis Desrichard Imen Medimegh Hager Ayari Nejla Stambouli Amel Mezlini Hssan Bouzayenne Raja Marrakchi Amel Benammar-Elgaaid Karim Bougatef 《Tumour biology》2014,35(1):545-551
Toll-like receptors (TLRs) are considered as major endotoxin-signaling receptor and as crucial sensors of innate immunity. TLRs recognize pathogen-associated molecular patterns; induce effectors genes involving inflammatory cytokines and therefore initiation of adaptative immune responses against pathogens. Recently, it has been shown that TLRs are involved in tumor progression. In fact, increased level of TLR4 is associated with progression of colon malignancies. Even, TLR4 polymorphism has been shown associated with susceptibility to have colorectal cancer. Our study aimed to investigate an association between TLR4 Asp299Gly (D299G) and Thr399Ile (T399I) polymorphisms in Tunisian patients with colorectal cancer. Using a primer extension method (SNaPshot), we genotyped two variants of TLR4 D299G and T399I in 100 patients with colorectal cancer and 140 healthy controls in Tunisian population. Interesting, we noted a significant association between T399I polymorphism and tumor differentiation (p?=?0.027) and tumor architecture (p?=?0.02) in colorectal cancer (CRC) patients. We also showed a significant association of D299G with an increased risk of advanced stage (p?=?0.03). Finally, we observed a positive link between D299G and T399I polymorphisms and CRC patients with lymph node (p?=?0.00024; p?=?0.0005, respectively) and metastasis (p?=?0.001; p?=?0.002, respectively). However, we found no evidence to support a significant association between TLR4 D299G and T399I polymorphisms and colorectal cancer susceptibility. Our findings suggest that TLR4 D299G and T399I polymorphisms are significantly associated with clinical features variables. TLR4 polymorphisms may serve as biomarker of disease progression. Therefore, our results need confirmation in even larger studies. 相似文献
46.
47.
48.
Ben Slimene I Tabbene O Djebali N Cosette P Schmitter JM Jouenne T Urdaci MC Limam F 《Research in microbiology》2012,163(5):388-397
An antagonist L194 strain against Phoma medicaginis pathogenic fungi was isolated from Tunisian soil (vicinity of Tunis) and identified as Bacillus subtilis based on biochemical characteristics and partial 16S rDNA sequence. When cells were grown in a minimal medium for 24 h, spore culture supernatant exhibited 2-fold higher antifungal activity than vegetative cells. MALDI-TOF mass spectrometry analysis showed that L194 spores produced mainly iturins, surfactins and fengycins with long-chain fatty acids, and other not yet identified compounds. Both vegetative cells and spores of L194 efficiently reduced germination of P. medicaginis conidia. As revealed by atomic force microscopy, L194 spores modified conidia morphology from a regular to a deflated shape. Data suggest that lipopeptides interacted with the cytoplasmic membrane, causing pore formation. In vivo, L194 spores were highly protective against P. medicaginis by reducing disease symptoms and alleviating growth disturbance of Medicago truncatula seedlings. As a whole, the lipopeptide-producing L194 strain may be successfully used in biocontrol of plant diseases induced by phytopathogenic fungi such as P. medicaginis. 相似文献
49.
50.