Pulmonary thromboembolism in neurosurgical patients. Part 2. Estimation of the informative value of determination of fibrinogen D-dimer levels in the preoperative period

The paper presents the results of clinical evaluation of the informative value of determination of blood fibrinogen D-dimer in 177 neurosurgical patients undergoing intracranial interventions for brain tumors. Screening detection of patients at high risk for thromboembolic complications is based on the determination of the blood levels of D-dimer on the first day after admission. To verify the diagnostic informative value of D-dimer determination, the patients with higher values (0.5+/-0.03 ng/l) underwent ultrasound scanning of lower extremity veins within the following 1-2 days. Despite its preliminary nature, the study showed the predictive value of determination of blood D-dimer levels in neurosurgical patients in the preoperative period and in the screening of prethrombotic events.     

Pulmonary thromboembolism in neurosurgical patients. Part 3. Analysis of the clinical effectiveness and safety of combined prevention of thromboembolic events in neurosurgical patients in the perioperative period

The paper presents the results of clinical evaluation of combined prevention of leg deep vein thrombosis and pulmonary thromboembolism in 130 neurosurgical patients undergoing intracranial interventions for brain tumors. Combined prevention comprises mechanical (compression knitted wear + periodic pneumatic leg compression by a special device) and pharmacological (subcutaneous injection of low molecular-weight heparins on postoperative day 2, followed by the daily administration of acetylsalicylic acid from the moment of a patient's activation) treatments. The study has indicated that this preventive procedure is effective and at the same time safe against the development of intracranial hemorrhagic complications.     

Combined Effects of Irradiation and Hindlimb Suspension on Erythroid Lineage Precursors from Rat Bone Marrow

Bulletin of Experimental Biology and Medicine - Erythroid precursors from the femoral bone marrow of Wistar rats were characterized after 30-day hindlimb suspension, fractionated γ-radiation,...     

Effect of the novel aminoadamantane derivative A-7 on Parkinsonian syndrome induced by systemic administration of neurotoxin MPTP

A new antiparkinsonian drug, N-(2-adamantyl)hexamethyleneimine hydrochloride (A-7), was studied on the model of parkinsonism syndrome (PS) induced by MPTP neurotoxin. A-7 (5-20 mg/kg) attenuated the MPTP induced akinesia and rigidity manifestations in C57B1/6 mice, the effect being more pronounced than that of cyclodol and levodopa and comparable to that of midantane (amantadine). A-7 also decreased the PS manifestations in rats: removed tremor, rigidity, and oligokinesia, normalized the MPTP-violated bioelectrical activity of nucleus caudatus, sensomotor cortex, and dorsal hippocamp, and eliminated pathologic slow activity, paroxysmal discharges, and high-frequency activity discharges. The activity of A-7 exceeded that of levodopa (enhancing tremor) and cyclodol (not eliminating the pathologic slow activity).     

The Effects of Transcranial Electrostimulation on the Adaptive State

The effects of transcranial electrostimulation on medical students with different types of adaptive responses (training, activation, stress, reactivation), levels of reactivity, and psychophysiological and autonomic status were studied. These experiments showed that transcranial electrostimulation was effective for subjects with adaptive responses of the training and activation types but not in those with stress combined with marked vagal tension. Transcranial electrostimulation facilitated improvements in psychophysiological parameters of the students and increased the level of body reactivity.     

Correlations of the antigenic specificity of human blood with the levels of antihemagglutinins to influenza viruses

The results of the observations show that after active circulation of influenza A (H1N1), A (H3N2), and B viruses the degree of immune response (a rise in antihemagglutinin titres to the causative agent of an epidemic) differed significantly in subjects with different blood groups of the ABO(H) system. After active circulation of influenza A(H1N1) and A(H3N2) viruses, rises in the antibody titres to the etiological factor of the epidemic was more marked in subjects with blood groups O and A than in those with blood group B. After an influenza A(H3N2) epidemic a rise in the titres to this virus in subjects with blood group B occurred a season later and did not reach those high levels observed in subjects with blood groups O and A. A reverse picture was observed during increasing morbidity and epidemic of influenza B virus. A rise in the antibody titres to this virus in subjects with blood group B significantly different from that among subjects with the other two blood groups occurred earlier, in the pre-epidemic season (the spring of 1980) and persisted till the end of the epidemic season. This time difference in the onset of the antibody titre rises appears to indicate a higher genetic sensitivity of subjects with blood group O followed by blood group A to influenza A viruses and, first of all, their increased sensitivity to A(H3N2) virus, as well as higher susceptibility to influenza B virus in subjects with blood group B.