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Acute Hemodilution: Its Effect on Hemodynamics and Oxygen Transport in Anesthetized Man 总被引:6,自引:0,他引:6 下载免费PDF全文
Hillel Laks Robert N. Pilon W. Peter Klovekorn Warwick Anderson John R. MacCallum Nicholas E. O''Connor 《Annals of surgery》1974,180(1):103-109
The effects of acute normovolemic hemodilution on hemodynamics, oxygen transport, tissue perfusion and blood volume were studied. The subjects were four patients undergoing total hip replacement with prebleeding and hemodilution under fluoroxene and nitrous oxide anesthesia. The hematocrit was reduced to 29% and 21% by bleeding in two steps with simultaneous infusion of plasmanate and lactated Ringer's solution. The major compensation was a rise in CO to 123% and 136%. Systemic oxygen transport (COX arterial O(2) content) was only slightly reduced and the arteriovenous oxygen difference decreased. Tissue perfusion remained excellent. Blood volume was slightly expanded. The procedure was well tolerated by this group of selected patients, and homologous blood utilization was markedly reduced. 相似文献
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D J Giles R J Thomas A G Osborn P D Clayton M H Miller A L Bahr P R Frederick G D O''Connor D Ostler 《Radiology》1984,150(3):719-722
Demographic and symptomatic data gathered from 460 patients referred for lumbosacral CT examinations were analyzed to determine if the prescan probability of normal or abnormal findings could be predicted accurately. We were unable to predict the presence of herniated disk on the basis of patient-supplied data alone. Age was the single most significant predictor of an abnormality and was sharply related to degenerative disease and spinal stenosis. 相似文献
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Robert E. O''Connor MD Jay S. Feldstein DO James K. Bouzoukis MD FRCS 《The Journal of emergency medicine》1985,2(6):433-442
Presented is a review of thoracentesis, a procedure with which the emergency physician should be familiar. The pathophysiology of pleural effusions is described and is followed by a review of the clinical presentation and diagnosis. Special attention is given to technique and interpretation of results. 相似文献
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L-5-hydroxytryptophan (L-5-HTP)-induced myoclonus was used as a behavioral index of central serotonergic activity. Estradiol benzoate (EB) and progesterone (P) influenced the induction of myoclonus by L-5-HTP. When L-5-HTP was injected 46 h after EB, myoclonus was enhanced. P blocked this effect on EB when 100 or 125 mg/kg L-5-HTP (but not 80 mg/kg) was given 6 h after P in EB-primed animals. When L-5-HTP was given 3 or 11-15 h after P in EB-primed animals, there was no inhibitory effect of P on myoclonus. In fact, at the lowest dose (80 mg/kg), L-5-HTP increased myoclonus when given 3 h after P in EB-primed animals. The inhibitory effects of P in EB-primed females on myoclonus were temporally correlated with the display of lordosis, suggesting that the neural progestin receptor mechanisms that have been proposed to mediate P effects on lordosis are also involved in the inhibitory effects of P on myoclonus. 相似文献
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以Fura-2/AM为细胞内钙离子的荧光指示剂,用AR-CM-MIC阳离子测定系统,直接测定了体外培养的新生大鼠神经细胞内游离钙([Ca2+]i)值,并观察了小檗碱(Ber)的影响。结果表明,Ber对神经细胞静息[Ca2+]i无明显影响,Ber1~100μmol·L-1能剂量依赖地抑制去甲肾上腺素和H2O2引起的[Ca2+]i升高,其IC50分别为39.9和17.9μmol·L-1。高剂量Ber(10~100μmol·L-1)能抑制高K+引起的[Ca2+]i升高。姐果提示,Ber对去甲肾上腺素,高K+及H2O2引起的[Ca2+]i升高的抑制作用可能是其抗脑缺血作用机制之一。 相似文献