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101.
Nuria Ribas Maite Domingo Paloma Gastelurrutia Andreu Ferrero-Gregori Pilar Rull Mariana Noguero Carmen Garcia Teresa Puig Juan Cinca Antoni Bayes-Genis 《Revista espa?ola de cardiología》2014
Introduction and objectives
In the general population, heart events occur more often during early morning, on Mondays, and during winter. However, the chronobiology of death in heart failure has not been analyzed. The aim of this study was to determine the circadian, day of the week, and seasonal variability of all-cause mortality in chronic heart failure.Methods
This was an analysis of all consecutive heart failure patients followed in a heart failure unit from January 2003 to December 2008. The circadian moment of death was analyzed at 6-h intervals and was determined by reviewing medical records and by information provided by the relatives.Results
Of 1196 patients (mean [standard deviation] age, 69 [13] years; 62% male), 418 (34.9%) died during a mean (standard deviation) follow-up of 29 (21) months. Survivors were younger, had higher body mass index, left ventricular ejection fraction, glomerular filtration rate, hemoglobin and sodium levels, and lower Framingham risk scores, amino-terminal pro-B type natriuretic peptide, troponin T, and urate values. They were more frequently treated with angiotensin receptor blockers, beta-blockers, mineralocorticoids receptor antagonists, digoxin, nitrates, hydralazine, statins, loop diuretics, and thiazides. The analysis of the circadian and weekly variability did not reveal significant differences between the four 6-h intervals or the days of the week. Mortality occurred more frequently during the winter (30.6%) compared with the other seasons (P = .024).Conclusions
All cause mortality does not follow a circadian pattern, but a seasonal rhythm in patients with heart failure. This finding is in contrast to the circadian rhythmicity of cardiovascular events reported in the general population.Full English text available from:www.revespcardiol.org/en 相似文献102.
Contador José Pérez-Millan Agnès Guillen Nuria Tort-Merino Adrià Balasa Mircea Falgàs Neus Olives Jaume Castellví Magdalena Borrego-Écija Sergi Bosch Beatriz Fernández-Villullas Guadalupe Ramos-Campoy Oscar Antonell Anna Bargalló Nuria Sanchez-Valle Raquel Sala-Llonch Roser Lladó Albert 《Journal of neurology》2022,269(5):2573-2583
Journal of Neurology - MRI atrophy predicts cognitive status in AD. However, this relationship has not been investigated in early-onset AD (EOAD, < 65 years) patients... 相似文献
103.
104.
Lucía Martínez‐Santamaría Claudio J. Conti Sara Llames Eva García Luisa Retamosa Almudena Holguín Nuria Illera Blanca Duarte Lino Camblor Jos M. Llaneza Jos L. Jorcano Fernando Larcher lvaro Meana María J. Escmez Marcela Del Río 《Experimental dermatology》2013,22(3):195-201
Cutaneous diabetic wounds greatly affect the quality of life of patients, causing a substantial economic impact on the healthcare system. The limited clinical success of conventional treatments is mainly attributed to the lack of knowledge of the pathogenic mechanisms related to chronic ulceration. Therefore, management of diabetic ulcers remains a challenging clinical issue. Within this context, reliable animal models that recapitulate situations of impaired wound healing have become essential. In this study, we established a new in vivo humanised model of delayed wound healing in a diabetic context that reproduces the main features of the human disease. Diabetes was induced by multiple low doses of streptozotocin in bioengineered human‐skin‐engrafted immunodeficient mice. The significant delay in wound closure exhibited in diabetic wounds was mainly attributed to alterations in the granulation tissue formation and resolution, involving defects in wound bed maturation, vascularisation, inflammatory response and collagen deposition. In the new model, a cell‐based wound therapy consisting of the application of plasma‐derived fibrin dermal scaffolds containing fibroblasts consistently improved the healing response by triggering granulation tissue maturation and further providing a suitable matrix for migrating keratinocytes during wound re‐epithelialisation. The present preclinical wound healing model was able to shed light on the biological processes responsible for the improvement achieved, and these findings can be extended for designing new therapeutic approaches with clinical relevance. 相似文献
105.
Ryoichi KAMIDE Laurent MISERY Nuria PEREZ‐CULLELL Vincent SIBAUD Charles TAÏEB 《The Journal of dermatology》2013,40(3):177-181
Sensitive skin syndrome was first described in 1977; however, no robust study has been carried out to evaluate its prevalence in Japan. A national representative sample of the Japanese population over the age of 18 years was taken. Individuals were questioned by telephone and selected according to the quota method. When asked “Do you have a sensitive skin?”, 52.84% of men and 55.98% of women answered “rather sensitive” or “very sensitive”. There was no significant difference (P = 0.22) between the two sexes. The non‐response rate among respondents was zero, suggesting that the term “sensitive skin” held a meaning for the majority of the population. Concerning questions about the onset of a rash, tingling or irritation in the presence of various factors, such as emotional issues, cold, heat, sun, dry air, air‐conditioning, water, air pollution and temperature variations, respondents with rather sensitive or very sensitive skin responded “yes” more often than others: approximately three‐times more often for water (18.97%/6.15%), air pollution (39.29%/12.45%) and warm climatic conditions (29.74%/9.8%). To our knowledge, this epidemiological study is the first to focus on sensitive skin among Japanese people of this century. It is of particular interest for two reasons: (i) it was conducted on a representative sample of the Japanese population; and (ii) the methodology used was identical to that used for sensitive skin assessment studies conducted in Europe and the USA, making it possible to draw certain comparisons. 相似文献
106.
Sam T. Douthwaite Charlotte Walker Elisabeth J. Adams Catherine Mak Andres Vecino Ortiz Nuria Martinez-Alier Simon D. Goldenberg 《Journal of clinical microbiology》2016,54(1):212-215
The performance of the Enigma MiniLab assay for influenza A and B viruses and respiratory syncytial virus (RSV) was compared to a centralized laboratory respiratory virus panel. The positive and negative percent agreement for influenza A virus, influenza B virus, and RSV were 79.2% (95% confidence interval [95% CI], 57.8 to 92.9%) and 99.4% (95% CI, 98.4 to 99.9), 100% (95% CI, 47.8 to 100%) and 100% (95% CI, 99.3 to 100%), 98.5% (95% CI, 94.6 to 99.8%) and 94.5% (95% CI, 91.9 to 96.4%), respectively. 相似文献
107.
ObjectiveThe study aimed at the assessment of disability in children with headache (n = 1585, 11–14 yrs) from a randomly drawn population based sample. We explored the suitability of the PedMIDAS in epidemiological research by various indicators of response quality. Furthermore, predictors of disability were examined, as well as its association with measures of health care behaviour.MethodsThe PedMIDAS measures functional interference in different domains of life by asking the children for the number of days that their headache partially or totally interfered with their activities.ResultsThe examination of response behaviour revealed a marked attrition of responses (missing, invalid) in two items. As a consequence, the total score for disability could not be obtained for about 25% of the children. Analysis of homogeneity of the PedMIDAS items revealed low item/total correlations in two items. The grading of disability resulted in 81.2% of all children with headache showing no or low disability. Only 1.4% was “severely” disabled. Disability was predicted by frequency, type and intensity of headache. From all psychological variables only dysfunctional stress coping was significantly associated with disability. Disability itself was significantly associated with medical consultation.ConclusionsSuitability of the PedMIDAS for epidemiological research was supported, however with a caveat and recommendations for item revision. Severe disability due to headache was rare in the studied unselected sample when defined by behavioural interference. It is suggested to explore the construct of disability by a multi-method approach, including further instruments assessing headache related distress, (respectively) quality of life. 相似文献
108.
Juan Vera Lourdes Ezpeleta Roser Granero Nuria de la Osa 《Child psychiatry and human development》2010,41(5):465-478
This study examined the prevalence, degree of association and differential effect, by sex and age, of conduct disorder symptoms
on psychopathology and functioning. Participants included 680 Spanish children and adolescents between 8 and 17 years and
their parents, attending to psychiatric outpatient consultation. Data were obtained through structured diagnostic interviews,
and other measures of psychopathological outcomes and functional impairment. In general, the prevalence of antisocial behavior
did not differ significantly by sex or age. Results indicated a higher frequency for 13–17 year olds, and a greater number
of symptoms in boys. Moreover, some symptoms of conduct disorder showed developmental variations. Sex and age differentially
affected the expression of some conduct disorder symptoms and their associations with functional impairment and severity of
psychopathology. Knowing the different expression of each symptom could help to identify these problems in clinical children
and adolescents, contributing to an early detection of population at the highest risk of serious psychopathology and worse
prognosis. 相似文献
109.
Andrés J. Muñoz Nuria Viñolas Ricardo Cubedo Dolores Isla 《Clinical & translational oncology》2011,13(8):592-596
The association between cancer and thrombosis is well established. Venous thromboembolism (VTE) is considered a main cause
of mortality and morbidity in cancer patients and is commonly underestimated by oncologists. In recent years the incidence
rates of VTE have notably increased. Several studies have clearly shown that cancer patients who are diagnosed with VTE present
a poorer prognosis. The Spanish Society of Medical Oncology (SEOM) presents the guidelines for thrombosis and cancer in order
to improve the prevention and management of VTE. 相似文献
110.
Alessandro Pecci Emanuele Panza Daniela De Rocco Nuria Pujol‐Moix Giorgia Girotto Luigi Podda Carmelo Paparo Valeria Bozzi Annalisa Pastore Carlo L. Balduini Marco Seri Anna Savoia 《European journal of haematology》2010,84(4):291-297
MYH9‐related disease (MYH9‐RD) is a rare autosomal dominant disorder caused by mutations in MYH9, the gene encoding the heavy chain of non‐muscle myosin IIA. All patients present congenital macrothrombocytopenia and inclusion bodies in neutrophils. Some of them can also develop sensorineural deafness, presenile cataract, and/or progressive nephropathy leading to end‐stage renal failure. We report four families, each with a novel mutation: two missense mutations, in exons 31 and 32, and two out of frame deletions in exon 40. They were associated with no bleeding diathesis, normal, or only slightly reduced platelet count and no extra‐hematological manifestations, confirming that alterations of the tail domain cause a mild form of MYH9‐RD with no clinically relevant defects. 相似文献