全文获取类型
收费全文 | 1753篇 |
免费 | 292篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 102篇 |
妇产科学 | 19篇 |
基础医学 | 101篇 |
口腔科学 | 34篇 |
临床医学 | 293篇 |
内科学 | 589篇 |
皮肤病学 | 60篇 |
神经病学 | 176篇 |
特种医学 | 279篇 |
外科学 | 188篇 |
综合类 | 31篇 |
预防医学 | 66篇 |
眼科学 | 16篇 |
药学 | 57篇 |
中国医学 | 1篇 |
肿瘤学 | 55篇 |
出版年
2024年 | 9篇 |
2023年 | 52篇 |
2022年 | 13篇 |
2021年 | 29篇 |
2020年 | 90篇 |
2019年 | 14篇 |
2018年 | 89篇 |
2017年 | 69篇 |
2016年 | 68篇 |
2015年 | 62篇 |
2014年 | 94篇 |
2013年 | 110篇 |
2012年 | 45篇 |
2011年 | 36篇 |
2010年 | 80篇 |
2009年 | 109篇 |
2008年 | 42篇 |
2007年 | 46篇 |
2006年 | 43篇 |
2005年 | 28篇 |
2004年 | 15篇 |
2003年 | 17篇 |
2002年 | 15篇 |
2001年 | 32篇 |
2000年 | 14篇 |
1999年 | 25篇 |
1998年 | 80篇 |
1997年 | 96篇 |
1996年 | 78篇 |
1995年 | 68篇 |
1994年 | 50篇 |
1993年 | 52篇 |
1992年 | 31篇 |
1991年 | 16篇 |
1990年 | 25篇 |
1989年 | 54篇 |
1988年 | 43篇 |
1987年 | 27篇 |
1986年 | 22篇 |
1985年 | 23篇 |
1984年 | 18篇 |
1983年 | 11篇 |
1982年 | 14篇 |
1981年 | 15篇 |
1980年 | 15篇 |
1979年 | 9篇 |
1977年 | 9篇 |
1976年 | 11篇 |
1975年 | 8篇 |
1971年 | 8篇 |
排序方式: 共有2084条查询结果,搜索用时 0 毫秒
91.
Oleksandr Danylenko MD PhD Elena Surkova MD PhD Roxy Senior MD DM Wei Li MD PhD 《Echocardiography (Mount Kisco, N.Y.)》2020,37(8):1315-1317
Accurate assessment of etiology of mitral regurgitation (MR) is one of the key steps in the decision-making process and further clinical management of patients with severe MR. Our clinical case illustrates the added value of three-dimensional echocardiography (3DE) in assessment of mitral valve morphology and identification of an unexpected mechanism of MR which was not previously diagnosed using conventional echocardiography. 3DE helped to choose appropriate management strategy in this patient. 相似文献
92.
Deepa Sasikumar DM Anoop Ayyappan DM Jineesh Valakkada DM Kavasseri Mahadevan Krishnamoorthy DM 《Echocardiography (Mount Kisco, N.Y.)》2020,37(9):1492-1494
Saline contrast echocardiography is a simple and effective method to diagnose the presence and type of right-to-left shunt in patients with unexplained cyanosis. It is considered a very sensitive test to diagnose pulmonary arteriovenous malformations. Our patient presented with unexplained cyanosis and transthoracic echocardiography showed an atrial septal defect and anomalous pulmonary venous drainage of the right and left upper pulmonary veins to the superior venacava. We describe how we used saline contrast echocardiography to demonstrate the presence of pulmonary arteriovenous malformations even in the presence of atrial septal defect and anomalous pulmonary venous drainage. 相似文献
93.
Jay Relan MD DM Mrigank Choubey MD Shyam Sunder Kothari MD DM 《Echocardiography (Mount Kisco, N.Y.)》2020,37(12):2168-2170
In cor triatriatum sinister, the left atrium is divided by a membrane into a proximal and a distal chamber. Usually proximal chamber receives all the pulmonary veins and drains through an opening in the dividing membrane into distal chamber, which empties into left ventricle through the mitral valve. Rarely, the two chambers lack a communication and there is associated total anomalous pulmonary venous connection (TAPVC). We report a 1-month-old infant with cyanosis and heart failure, who had cor triatriatum sinister associated with supracardiac TAPVC. The case is reported for rarity of the association with a focus on contrast echocardiographic imaging. 相似文献
94.
95.
Do Obese Individuals With Hypertension Have More Difficult‐to‐Control Blood Pressure and End Organ Damage Than Their Nonobese Counterparts? 下载免费PDF全文
Mark David Jesky MBChB Manvir Kaur Hayer MBChB Mark Thomas MD Indranil Dasgupta DM 《Journal of clinical hypertension (Greenwich, Conn.)》2015,17(6):466-472
The authors assessed whether individuals with elevated body mass index (BMI) and hypertension had more difficult‐to‐control blood pressure (BP) and more evidence of end organ damage using data collected prospectively over 11 years from a secondary care hypertension clinic. A total of 1114 individuals were divided by BMI criteria into normal (n=207), overweight (n=440), and obese (n=467). Mean daytime, nighttime, and 24‐hour systolic BP and diastolic BP were similar in all groups. There was less nocturnal dip in obese compared with overweight groups (P=.025). Individuals with a normal BMI were taking fewer antihypertensive medications than those in the obese group (P=.01). Individuals classified as obese had a higher left ventricular mass index than those with a normal BMI (female, P=.028; male, P<.001); this relationship remained after multivariate linear regression. Obese individuals with hypertension required more medication to achieve similar mean ambulatory BP values, had less nocturnal dip in BP, and had a higher prevalence of left ventricular hypertrophy. As such, obese patients are at potentially increased risk of cardiovascular events. 相似文献
96.
Unusual association of a unique CAG interruption in 5′ of DM1 CTG repeats with intergenerational contractions and low somatic mosaicism 下载免费PDF全文
Stéphanie Tomé Alexis Bertrand David Geneviève Yann Péréon DM contraction study group Marie Simon Jean‐Paul Bonnefont Guillaume Bassez Geneviève Gourdon 《Human mutation》2018,39(7):970-982
Myotonic dystrophy type 1 (DM1) is a dominant multisystemic disorder associated with high variability of symptoms and anticipation. DM1 is caused by an unstable CTG repeat expansion that usually increases in successive generations and tissues. DM1 family pedigrees have shown that ~90% and 10% of transmissions result in expansions and contractions of the CTG repeat, respectively. To date, the mechanisms of CTG repeat contraction remain poorly documented in DM1. In this report, we identified two new DM1 families with apparent contractions and no worsening of DM1 symptoms in two and three successive maternal transmissions. A new and unique CAG interruption was found in 5′ of the CTG expansion in one family, whereas multiple 5′ CCG interruptions were detected in the second family. We showed that these interruptions are associated with maternal intergenerational contractions and low somatic mosaicism in blood. By specific triplet‐prime PCR, we observed that CTG repeat changes (contractions/expansions) occur preferentially in 3′ of the interruptions for both families. 相似文献
97.
98.
Epstein-Barr virus lymphoproliferation after bone marrow transplantation 总被引:16,自引:7,他引:16
We review 15 cases of secondary B-cell lymphoproliferative disorders that occurred among 2,475 patients who received allogeneic bone marrow transplants (BMTs) at the Fred Hutchinson Cancer Research Center (Seattle) between 1969 and 1987. The histopathologic findings in 14 of the 15 patients spanned a wide spectrum of lymphoproliferative lesions. One patient had features characteristic of angioimmunoblastic lymphadenopathy. Epstein-Barr virus (EBV) genomic sequences were identified by Southern blot analysis in each of the 13 patients evaluated. Ten of the 12 lesions evaluated originated in donor cells. In two patients, who had mixed chimerism after transplantation, the lesions originated in host cells. The combined evidence from immunoglobulin light chain staining and the analysis of immunoglobulin heavy chain gene rearrangement indicated that the lesions in most patients represented polyclonal proliferations that gave rise to clonal subpopulations. The results indicate an overall actuarial incidence of 0.6% for this complication in BMT recipients. Anti-CD3 monoclonal antibody (MoAb) treatment of acute graft-v-host disease (GVHD) and T cell depletion of the donor marrow were statistically significant risk factors, and GVHD appeared to play a contributing role, particularly in the setting of human leukocyte antigen (HLA) disparity. Two patients had no identifiable risk factors. Prophylaxis or treatment with acyclovir had no detectable effect in the patients; all but two died with uncontrolled lymphoproliferation. 相似文献
99.
Failed Attempt With Paired Associative Stimulation to Separate Functional and Organic Dystonia 下载免费PDF全文
100.
Trajectories of impairment in amyotrophic lateral sclerosis: Insights from the Pooled Resource Open‐Access ALS Clinical Trials cohort 下载免费PDF全文
Nimish J. Thakore MD DM Brittany R. Lapin PhD MPH Erik P. Pioro MD PhD Pooled Resource Open‐Access ALS Clinical Trials Consortium 《Muscle & nerve》2018,57(6):937-945
Introduction: Rate of decline of the Amyotrophic Lateral Sclerosis Functional Rating Scale‐Revised (ALSFRS‐R) score is a common outcome measure and a powerful predictor of mortality in ALS. Methods: Observed rate of decline (postslope) of ALSFRS‐R, its linearity, and its relationship to decline at first visit (preslope) were examined in the Pooled Resource Open‐Access ALS Clinical Trials cohort by using longitudinal mixed effects models. Results: Mean ALSFRS‐R postslope in 3,367 patients was ?0.99 points/month. Preslope and postslope were correlated and had powerful effects on survival. ALSFRS‐R trajectories were slightly accelerated overall, but slope and direction/degree of curvature varied. Subscore decline was sequential by site of onset. Respiratory subscore decline was the least steep. Discussion: Variable curvilinearity of ALSFRS‐R trajectories confounds interpretation in clinical studies that assume linear decline. Subscore trajectories recapitulate phenotypic diversity and topographical progression of ALS. ALSFRS‐R is better used as a multidimensional measure. Muscle Nerve 57 : 937–945, 2018 相似文献