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排序方式: 共有9526条查询结果,搜索用时 390 毫秒
31.
Hiroko Nishida Mitsuru Murata Koichi Miyaki Kazuyuki Omae Kiyoaki Watanabe Yasuo Ikeda 《Blood coagulation & fibrinolysis》2006,17(3):203-207
We used the Gorog Thrombosis Test to analyze the factors influencing the occlusion time, which represents platelet activation and subsequent occlusive thrombus formation, in 132 healthy Japanese volunteers (116 men, 16 women; mean age, 45.0 +/- 12.0 years). The Gorog Thrombosis Test was designed to evaluate platelet aggregation and thrombolytic activity under a high shear stress condition (175 dynes/cm) in a native blood sample in vitro. The mean +/- SD occlusion time was 154.8 +/- 64.7 s (men, 153.4 +/- 64.2 s and women, 165.4 +/- 56.5 s). The occlusion time was inversely correlated with von Willebrand factor ristocetin cofactor activity (VWF:Rco) (r = -0.242, P = 0.0055) and von Willebrand factor antigen (r = -0.230, P = 0.0080). The mean occlusion time in the group with VWF:Rco of at least 170% (137 s) was significantly shorter than that in the group with VWF:Rco less than 170% (156 s, P < 0.05). Platelet counts, other coagulation markers and smoking showed no significant correlations with occlusion time. Red blood cells (r = -0.177, P = 0.0365), hemoglobin (r = -0.191, P = 0.0245) and hematocrit (r = -0.182, P = 0.0329) also showed inverse correlations with the occlusion time. This report is the first to clearly demonstrate the role of von Willebrand factor in the formation of occlusive thrombi in the Gorog Thrombosis Test. 相似文献
32.
Summary The blood-brain barrier breaks down following cerebral ischemia, but the exact sequence of events for extravasation of serum proteins and their parenchymal distribution remain uncertain. We studied the distribution of serum albumin in the hippocampus of the gerbil brain using light and electron microscopic immunocytochemical techniques. With light microscopy, there was no reaction for albumin for the first 12 h after unilateral common carotid artery occlusion for 10 min and reperfusion. At 12 h, the reaction was weak and limited to the neuropil in the subiculum-CA1 region (between the subiculum and the medial CA1 region). After 24 h, the reaction became intense in the neuropil and neuronal perikarya in the subiculum-CA1 and medial CA1 regions. The electron microscopic immunocytochemical study of the subiculum-CA1 and medial CA1 regions revealed electron-dense immunoprecipitates in the extracellular space and the peripheral part of the apical dendrites as early as 30 min after reperfusion and in the astrocytic cytoplasm after reperfusion for 1 h. However, immunoprecipitates were not found in the neuronal perikarya until after reperfusion for 24 h. The present study demonstrated prompt appearance of albumin in the extracellular space of the brain parenchyma after re-establishment of cerebral circulation and prompt accumulation in the peripheral part of the dendrites with spreading to neuronal perikarya, likely in the process of degeneration and death.Supported by the grant NS-06663 from the National Institutes of Health, U. S. Public Health Service 相似文献
33.
S Kasai M Sawa S Hirai Y Nishida K Onodera T Yamamoto M Mito 《Transplantation proceedings》1992,24(6):2990-2992
34.
Fluid-fluid levels in cavernous hemangioma of soft tissue 总被引:3,自引:0,他引:3
Shigeru Ehara M.D. Miyuki Sone Yoshiharu Tamakawa Jun Nishida Masataka Abe Junichi Hachiya 《Skeletal radiology》1994,23(2):107-109
Five cases of cavernous hemangioma with fluid-fluid levels on magnetic resonance imaging and/or computed tomography are reported. The signal characteristics were those of blood and histological analysis of the fluid-fluid levels showed that they were blood-filled cavities in the tumor. Although this finding itself is not specific, it may help in confirming the diagnosis of cavernous hemangioma. 相似文献
35.
Toshiji Ishiwata Ryo Koyama Noriyuki Homma Mitsuhiro Fujii Naoko Iwakami Yuta Nakao Shin-ichiro Iwakami Kazuhisa Takahashi 《Nihon Kokyūki Gakkai zasshi》2006,44(10):749-753
A 28-year-old man complaining of myiodesopsia was given a diagnosis of uveitis. Subsequently he complained facial nerve palsy and enlargement of parotid gland. Heerfordt's syndrome was diagnosed based on the results of several examinations. Facial nerve palsy, enlargement of the parotid gland and uveitis were improved by systemic corticosteroid therapy. At present he is receiving systemic corticosteroid therapy, but numbness in the mouth, thought to be the involvement of the trigeminal nerve, remains. Systemic corticosteroid therapy is usually effective for most cases with Heerford's syndrome. On the other hand, there are some cases with the prolonged peripheral nerve involvement despite systemic corticosteroid therapy, as seen in this case. If peripheral nerve involvement is prolonged, it is necessary to consider small-fibre neuropathy as one possible cause. 相似文献
36.
37.
Yusuke Ando Takahiro Nishida Shigeki Morita Munetaka Masuda Yukihiro Tomita Ryuji Tominaga 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(8):335-337
Infective endocarditis of the mitral area accompanied by anorexia nervosa is extremely rare. A 34-year-old Japanese woman presented with high fever and a heart murmur that had developed over the previous 2-month period. Echocardiography revealed mitral regurgitation and vegetation attached to the anterior mitral leaflet, which had markedly prolapsed to the left atrium. We removed the vegetation with a small part of the anterior mitral leaflet and successfully repaired the mitral valve. The patient showed good recovery, and the mitral regurgitation and left ventricular chamber size had satisfactorily decreased at 2 months after the operation. 相似文献
38.
Serum levels of free insulin-like growth factor (IGF)-I were measured by
immunoradiometric assay (IRMA) in fasting sera of 137 normal boys and 120 normal girls
aged from 8 to 15 yr to study relationships between free IGF-I levels and ages, total
IGF-I, IGF binding protein (IGFBP)-1, IGFBP-3, and acid-labile subunit (ALS) levels. In
both sexes, serum free IGF-I levels and the ratios of free IGF-I to total IGF-I were
significantly higher in the pubertal age groups than in the prepubertal age groups. Serum
levels of free IGF-I showed a significant positive correlation with those of total IGF-I,
IGFBP-3 and ALS, while they showed a significant negative correlation with those of
IGFBP-1. These observations suggest that increase in serum free IGF-I levels during
puberty is caused by a dramatic increase in total IGF-I, rather than IGFBP-3, and a
decrease in IGFBP-1. Also, high free IGF-I levels may play an important role in pubertal
growth spurt. 相似文献
39.
Introduction The authors report a case of interhemispheric ependymal cyst accompanied with agenesis of the corpus callosum in a fetus.
Discussion Routine ultrasound and subsequent magnetic resonance imaging of a 20-year-old woman at 33 weeks and 1 day of gestation detected
a large interhemispheric cystic lesion in the fetal cranial cavity. Caesarian section was carried out at 36 weeks because
of the progressive enlargement of the fetal head. The cyst was multiloculated and a cyst peritoneal shunt placement resulted
in collapse of the drained cyst components followed by enlargement of others. After wrack-a-mole-like shunt revisions, open
surgery was performed at the age of 2 years. Cyst walls were fenestrated and the cavities were communicated with each other
and eventually with the lateral ventricle. Pathological diagnosis of the cyst wall was ependymal cyst. The boy is now 3 years
old, and growing without apparent developmental delay or recurrence. Current concept and management policy of the interhemispheric
cyst accompanied with agenesis of the corpus callosum is reviewed. 相似文献
40.
Shinji Nakashima Masayuki Morikawa Kanshi Komatsu Akihiro Matsuura Noriyuki Sato Tomio Abe 《The Journal of heart and lung transplantation》2005,24(4):462-469
OBJECTIVE: NKH477 was recently identified as a water-soluble forskolin derivative and was reported to prolong survival of murine cardiac allografts. However, the mechanism of the efficacy is not clear in vivo. The aim of this study was to investigate the immunosuppressive effects of NKH477 on acute lung allograft rejection in the rat model and its mechanism of action in vivo. METHODS: Left lungs were transplanted orthotopically from Brown-Norway donors to Lewis recipients. Recipient rats were untreated or treated daily with different doses of NKH477. Grafts were excised on Day 3 or Day 5 to determine histopathological rejection and expressions of interleukin (IL)-2, IL-4, IL-10, and interferon (IFN)-gamma by enzyme-linked immunosorbent assay. The cytokine expression at Day 3 or Day 5 was also evaluated in recipient spleens by immunohistochemistry. Furthermore, mesenteric lymph node cells from recipients at Day 5 were cultured alone or stimulated with donor antigens for 72 hours to determine cell proliferation by means of thymidine incorporation. RESULTS: NKH477 significantly extended allograft survival time in a dose-dependent manner and reduced histopathological rejection. Treatment with NKH477 inhibited IFN-gamma and IL-10 expression, whereas expression of these cytokines were markedly upregulated in the untreated allografts. Expression of IL-2 and IL-10 also increased in the spleen of untreated allorecipients. NKH477 suppressed expression of both cytokines in the spleen. In addition, lymphocyte proliferation was inhibited in NKH477-treated recipients as compared with untreated recipients. CONCLUSION: These results suggest that NKH477 exerts an antiproliferative effect on lymphocytes in vivo with an altered cytokine profile in rat recipients of lung allografts. 相似文献