全文获取类型
收费全文 | 5801篇 |
免费 | 358篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 175篇 |
妇产科学 | 69篇 |
基础医学 | 977篇 |
口腔科学 | 134篇 |
临床医学 | 387篇 |
内科学 | 1413篇 |
皮肤病学 | 188篇 |
神经病学 | 494篇 |
特种医学 | 203篇 |
外科学 | 611篇 |
综合类 | 13篇 |
预防医学 | 243篇 |
眼科学 | 211篇 |
药学 | 440篇 |
中国医学 | 20篇 |
肿瘤学 | 591篇 |
出版年
2024年 | 5篇 |
2023年 | 47篇 |
2022年 | 106篇 |
2021年 | 183篇 |
2020年 | 87篇 |
2019年 | 90篇 |
2018年 | 164篇 |
2017年 | 136篇 |
2016年 | 149篇 |
2015年 | 155篇 |
2014年 | 236篇 |
2013年 | 244篇 |
2012年 | 357篇 |
2011年 | 452篇 |
2010年 | 263篇 |
2009年 | 218篇 |
2008年 | 401篇 |
2007年 | 429篇 |
2006年 | 402篇 |
2005年 | 438篇 |
2004年 | 359篇 |
2003年 | 343篇 |
2002年 | 349篇 |
2001年 | 46篇 |
2000年 | 26篇 |
1999年 | 59篇 |
1998年 | 56篇 |
1997年 | 43篇 |
1996年 | 42篇 |
1995年 | 35篇 |
1994年 | 47篇 |
1993年 | 27篇 |
1992年 | 19篇 |
1991年 | 23篇 |
1990年 | 16篇 |
1989年 | 20篇 |
1988年 | 18篇 |
1987年 | 14篇 |
1986年 | 15篇 |
1985年 | 10篇 |
1984年 | 13篇 |
1983年 | 9篇 |
1982年 | 6篇 |
1981年 | 10篇 |
1980年 | 4篇 |
1979年 | 7篇 |
1977年 | 5篇 |
1971年 | 3篇 |
1964年 | 3篇 |
1963年 | 2篇 |
排序方式: 共有6203条查询结果,搜索用时 15 毫秒
91.
Tatsuro Tamatsukuri Masayuki Ohbayashi Noriko Kohyama Yasuna Kobayashi Toshinori Yamamoto Kenichiro Fukuda Shunsuke Nakamura Yasufumi Miyake Kenji Dohi Mari Kogo 《Journal of infection and chemotherapy》2018,24(10):834-840
In recent years, augmented renal clearance (ARC), in which renal function is excessively enhanced, has been reported, and its influence on β-lactam antibiotics has been investigated. In this study, we aimed to determine the optimum population pharmacokinetic model of meropenem in patients with sepsis with ARC, and evaluated dosing regimens based on renal function. Seventeen subjects (6 with ARC and 11 without) were enrolled in this study. Predicted meropenem concentrations were evaluated for bias and precision using the Bland–Altman method. To examine the dosing regimen, Monte Carlo simulation was performed to calculate the cumulative fraction of response (CFR). In patients with ARC, the bias (average of the predicted value and measured value residuals) of models constructed by Crandon et al. (2011), Roberts et al. (2009), and Jaruratanasirikul et al. (2015) were 5.96 μg/mL, 10.91 μg/mL, and 4.41 μg/mL, respectively. Following 2 g meropenem every 8 h (180 min infusion), CFR ≥ 90%, a criterion of success for empirical therapy, was achieved, even with creatinine clearance of 130–250 mL/min. For patients with sepsis and ARC, the model of Jaruratanasirikul et al. showed the highest degree of accuracy and precision and confirmed the efficacy of the meropenem dosing regimen in this patient population. 相似文献
92.
Taito Kitano Yuki Nishikawa Satoru Sueyoshi Noriko Horikawa Hiroyuki Nakagawa Sayaka Yoshida 《Journal of infection and chemotherapy》2018,24(3):224-227
Hepatic abscess in chronic granulomatous disease (CGD) is very refractory and frequently requires multiple surgeries with frequent morbidities. Although surgical interventions are often required, patients are often not able to have surgery for various reasons. We present the case of a 21-year-old man with recurrent hepatic abscess in CGD. We could not provide surgical interventions due to the lack of a fluid cavity and the patient's refusal, and therefore we administered transcatheter arterial antimicrobial and steroid therapy. He did not have any exacerbation for more than 18 months after the final transcatheter treatment. This is the first reported case of successful transcatheter arterial antimicrobial and steroid therapy for refractory hepatic abscess in CGD. Although the patient's burden and medical cost were not inconsequential, this case shows that the transcatheter arterial antimicrobial and steroid therapy may be a treatment option for patients who are not candidates for surgical interventions. 相似文献
93.
Issei Tokimatsu Katsumi Shigemura Kayo Osawa Shinya Kinugawa Koichi Kitagawa Noriko Nakanishi Hiroyuki Yoshida Soichi Arakawa Masato Fujisawa 《Journal of infection and chemotherapy》2018,24(8):641-647
We conducted a nationwide molecular epidemiological study of Clostridium difficile infection (CDI) in Japan investigated the correlation between the presence of binary toxin genes and CDI severity. This is the first report on molecular epidemiological analyses for CDI in multiple university hospitals in Japan, to our knowledge. We examined 124,484 hospitalized patients in 25 national and public university hospitals in Japan between December 2013 and March 2014, investigating antimicrobial susceptibilities and toxin-related genes for C. difficile isolates from stools. Epidemiological genetic typing was performed by PCR-ribotyping and repetitive sequence-based (rep)-PCR to examine the genetic similarities. The results detected toxin A-positive, toxin B-positive, binary toxin-negative (A+B+CDT?) detected from 135 isolates (80.8%) and toxin A-negative, toxin B-positive, binary toxin-negative (A??B+CDT?) in 23 (13.8%). Toxin A-positive, toxin B-positive, and binary toxin-positive (A+B+CDT+) were seen in 9 isolates (5.4%). Vancomycin (n = 81, 37.7%) or metronidazole (n = 88, 40.9%) therapies were undertaken in analyzed cases. Ribotypes detected from isolates were 017/subgroup 1, 070, 078, 126, 176, 449, 475/subgroup 1, 499, 451, 566 and newtypes. Rep-PCR classified 167 isolates into 28 cluster groups including 2–15 isolates. In addition, 2 pairs of strains isolated from different institutions belonged to the same clusters. Seven out of 9 (77.8%) of the patients with binary toxin producing strains had “mild to moderate” outcome in evaluated symptoms. In conclusion, we found that binary toxin did not show regional specificity and had no relevance to severity of CDI. 相似文献
94.
Nobuya Kobayashi Hideki Kobara Noriko Nishiyama Masao Fujiwara Keiichi Okano 《Minimally invasive therapy & allied technologies》2018,27(4):203-208
Background: Endoscopic submucosal dissection (ESD) techniques, such as generating an artificial space between digestive tract layers for safer dissection, were thought to be safer for the resection of organs in cholecystectomy. We investigated whether combinations of endoscopic techniques and laparoscopic techniques could be performed more safely and rapidly.Material and methods: Laparoscopic and endoscopic cooperative-cholecystectomy (LEC-chole) and conventional laparoscopic cholecystectomy (Lapa-chole) were performed in six dogs. Operation time was defined as the time from the creation of the first port to the retrieval of the resected gallbladder (GB); and GB bed dissection time was the time from local injection of natural saline to the clipping of the cystic duct. The main roles of the endoscope in LEC-chole were to obtain a sufficient cutting space via local injection of natural saline to the GB bed and to monitor the operative view without laparoscopic camera, thus omitting the umbilical port.Results: The operation times were 60?±?18.3?minutes for LEC-chole and 95?±?7.0 for Lapa-chole (p?=?.036). The GB bed dissection times were 31?±?8.54?minutes in LEC-chole and 50.6?±?7.37?minutes in Lapa-chole (p?=?0.048). There were significant differences in liver damage and bleeding (p?=?0.116), but there were no significant differences in one-month survival.Conclusions: The application of LEC-chole may be expanded to cholecystectomy. 相似文献
95.
96.
Makoto Nishio Atsushi Horiike Hiroshi Nokihara Hidehito Horinouchi Shinji Nakamichi Hiroshi Wakui Fumiyoshi Ohyanagi Keita Kudo Noriko Yanagitani Shunji Takahashi Yasutoshi Kuboki Noboru Yamamoto Yasuhide Yamada Masaichi Abe Takashi Tahata Tomohide Tamura 《Investigational new drugs》2015,33(3):632-640
97.
Hiroaki Kataoka Kazumi Dokai Mochimasu Akihiko Katayama Kanae Oda Kanda Noriko Sakano Keiko Tanaka Nobuyuki Miyatake 《Environmental health and preventive medicine》2015,20(1):63-67
Objective
The aim of this study was to investigate the linkage among climate parameters, total ambulance transports and the number of deaths in Asahikawa City in northern Japan.Methods
Monthly data on total ambulance transports and the number of deaths from January 2004 to December 2011 were obtained from Asahikawa City Fire Department and the Asahikawa City official website. Climate parameters for the required period were also obtained from the Japan Meteorological Agency, Japan. To adjust for the population, we also used monthly population data on Asahikawa City. The linkage among climate parameters, total ambulance transports and the number of deaths was evaluated by ecological analysis.Results
The mean air temperature in the Asahikawa area was 7.3 ± 10.1 °C. Total ambulance transports (/a hundred thousand people/day) and the number of deaths (/a hundred thousand people/day) were 10.0 ± 0.6 and 2.6 ± 0.3, respectively. Using quadratic curves, total ambulance transports and the number of deaths were weakly correlated with some climate parameters. The number of deaths was weakly and positively correlated with total ambulance transports.Conclusion
A weak linkage among climate parameters, total ambulance transports and the number of deaths was noted in Asahikawa City, Japan. However, these associations were not as high as expected. 相似文献98.
Naomi Sekizuka-Kagami Keiko Shimada Noriko Tabuchi Hiroyuki Nakamura 《Environmental health and preventive medicine》2015,20(2):90-96
Objectives
The purpose of this study is to determine whether the score of the sense of coherence 13-item version (SOC-13) scale in the second trimester of pregnancy is associated with threatened premature birth.Methods
All the subjects gave their informed written consent before their participation in the study. A self-reported questionnaire survey was conducted on the pregnant women at approximately 18 weeks of pregnancy. The questionnaire consisted of items on demographic characteristics, perinatal abnormalities, stress perception scale (SPS), and SOC-13 scale. Approximately 30 weeks of pregnancy after the first survey, we surveyed whether any treatment had been provided for threatened premature birth during the course of the current pregnancy. The study period was from December 2007 to February 2010. One hundred and seventy-seven pregnant women participated in the study, but only the data from 151 pregnant women were analyzed.Results
Forty-three (28.5 %) pregnant women had threatened premature birth and received some treatment. Logistic regression analysis was carried out with threatened premature birth as the dependent variable and age, childbirth history, smoking habit, history of miscarriage or premature birth in previous pregnancies, SPS score, and SOC-13 scale score as the independent variables. It was shown that SOC-13 scale score affected threatened premature birth (p < 0.001) and that a low SOC-13 scale score was associated with threatened premature birth.Conclusions
This study suggests that the SOC-13 scale score in the second trimester of pregnancy could be of great value in clinical health care of pregnant women with a risk of threatened premature birth in the subsequent course of pregnancy. 相似文献99.
100.
Kanako Terakawa Naoki Sawa Hiroki Mizuno Akinari Sekine Noriko Hayami Daisuke Ikuma Masahiro Kawada Rikako Hiramatsu Keiichi Sumida Masayuki Yamanouchi Eiko Hasegawa Tatsuya Suwabe Junichi Hoshino Keiichi Kinowaki Kenichi Ohashi Takeshi Fujii Yoshifumi Ubara 《Internal medicine (Tokyo, Japan)》2021,60(8):1237
A 74-year-old Japanese woman diagnosed with autosomal dominant polycystic kidney disease (ADPKD) was admitted to our institute for the further examination of right-side groin pain developing in the past week. The patient was diagnosed with polymyositis (PM). Diagnostic imaging showed a mass lesion measuring 8 cm and a renal stone in the right kidney. Immediately following surgical resection of the right kidney, the patient''s serum CK decreased to the normal range. A histopathological analysis showed well-differentiated squamous cell carcinoma. In conclusion, this case showed a close relationship between the occurrence of squamous cell carcinoma and the development of PM in an ADPKD patient. 相似文献