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41.
We report a case of a young hypertensive male who was first seen in 1998 with a right thalamic haemorrhage and uncontrolled hypertension. CT abdomen showed a right adrenal tumour and a hyperplastic left adrenal gland. Laparoscopic adrenalectomy performed followed by histopathological examination confirmed the diagnosis of adrenal adenoma. He subsequently presented to us again a year later with persistent hyperkalaemia and asymptomatic hyponatraemia. Further investigations strongly suggested the presence of isolated mineralocorticoid deficiency with normal cortisol levels. This was confirmed to be due to partial or late-onset congenital adrenal hyperplasia (CAH). We discuss the association of partial CAH and adrenal tumours and the unmasking of the mineralocorticoid deficiency following adrenalectomy. 相似文献
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Abd Rashid Nur Haslindawaty Sundararajulu Panneerchelvam Hisham Atan Edinur Mohd Nor Norazmi Zainuddin Zafarina 《International journal of legal medicine》2010,124(5):415-426
The uniparentally inherited mitochondrial DNA (mtDNA) is in the limelight for the past two decades, in studies relating to
demographic history of mankind and in forensic kinship testing. In this study, human mtDNA hypervariable segments 1, 2, and
3 (HV1, HV2, and HV3) were analyzed in 248 unrelated Malay individuals in Peninsular Malaysia. Combined analyses of HV1, HV2,
and HV3 revealed a total of 180 mtDNA haplotypes with 149 unique haplotypes and 31 haplotypes occurring in more than one individual.
The genetic diversity was estimated to be 99.47%, and the probability of any two individuals sharing the same mtDNA haplotype
was 0.93%. The most frequent mtDNA haplotype (73, 146, 150, 195, 263, 315.1C, 16140, 16182C, 16183C, 16189, 16217, 16274,
and 16335) was shared by 11 (4.44%) individuals. The nucleotide diversity and mean of pair-wise differences were found to
be 0.036063 ± 0.020101 and 12.544022 ± 6.230486, respectively. 相似文献
43.
Vaccine development against the blood-stage malaria parasite is aimed at reducing the pathology of the disease. We constructed
a recombinant Mycobacterium bovis bacille Calmette Guerin (rBCG) expressing the 19 kDa C-terminus of Plasmodium falciparum merozoite surface protein-1 (MSP-119) to evaluate its protective ability against merozoite invasion of red blood cells in vitro. A mutated version of MSP-119, previously shown to induce the production of inhibitory but not blocking antibodies, was cloned into a suitable shuttle
plasmid and transformed into BCG Japan (designated rBCG016). A native version of the molecule was also cloned into BCG (rBCG026).
Recombinant BCG expressing the mutated version of MSP-119 (rBCG016) elicited enhanced specific immune response against the epitope in BALB/c mice as compared to rBCG expressing the
native version of the epitope (rBCG026). Sera from rBCG016-immunized mice contained significant levels of specific IgG, especially
of the IgG2a subclass, against MSP-119 as determined by enzyme-linked immunosorbent assay. The sera was reactive with fixed P. falciparum merozoites as demonstrated by indirect immunofluorescence assay (IFA) and inhibited merozoite invasion of erythrocytes in
vitro. Furthermore, lymphocytes from rBCG016-immunized mice demonstrated higher proliferative response against the MSP-119 antigen as compared to those of rBCG026- and BCG-immunized animals. rBCG expressing the mutated version of MSP-119 of P. falciparum induced enhanced humoral and cellular responses against the parasites paving the way for the rational use of rBCG as a blood-stage
malaria vaccine candidate. 相似文献
44.
Nik Soriani Yaacob Nurraihana Hamzah Nik Nursyazni Nik Mohamed Kamal Siti Amalina Zainal Abidin Choon Sheen Lai Visweswaran Navaratnam Mohd Nor Norazmi 《BMC complementary and alternative medicine》2010,10(1):42
Background
The leaves of Strobilanthes crispus (S. crispus) which is native to the regions of Madagascar to the Malay Archipelago, are used in folk medicine for their antidiabetic, diuretic, anticancer and blood pressure lowering properties. Crude extracts of this plant have been found to be cytotoxic to human cancer cell lines and protective against chemically-induced hepatocarcinogenesis in rats. In this study, the cytotoxicity of various sub-fractions of dichloromethane extract isolated from the leaves of S. crispus was determined and the anticancer activity of one of the bioactive sub-fractions, SC/D-F9, was further analysed in breast and prostate cancer cell lines. 相似文献45.
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47.
Pheochromocytoma is a rare catecholamine-secreting tumour typically arising within the adrenal medulla. It may occur sporadically or be associated as part of a tumour syndrome including Von Hippel Lindau (VHL), Multiple Endocrine Neoplasia (MEN) 2 and Neurofibromatosis Type 1. VHL is associated with multi-organ involvement of benign and malignant tumours characterized by the presence of retinal angiomas, hemangioblastomas of the cerebellum and spinal cord, renal cell carcinomas, pheochromocytomas and other cystic lesions in the kidneys, pancreas, and epididymis. It is a rare disorder with prevalence estimated at 2-3 per 100,000. This case report describes a 37 years old Chinese gentleman who presented to our institution for further management of bilateral pheochromocytoma and retinal angioblastoma with problems of duodenal ulcer and anaemia. There was no family history of similar problems. With these features the criteria for the diagnosis of von Hippel Lindau disease was established. 相似文献
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Comparative study of IgA VH3 gene usage in healthy TST− and TST+ population exposed to tuberculosis: deep sequencing analysis
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Siang Tean Chin Joshua Ignatius Siti Suraiya Gee Jun Tye Maria E Sarmiento Armando Acosta Mohd Nor Norazmi Theam Soon Lim 《Immunology》2015,144(2):302-311
The acquired immune response against tuberculosis is commonly associated with T-cell responses with little known about the role of B cells or antibodies. There have been suggestions that B cells and humoral immunity can modulate the immune response to Mycobacterium tuberculosis. However, the mechanisms involving B-cell responses in M. tuberculosis are not fully understood, in particular the antibody gene preferences. We hypothesized that a preferential use of V genes can be seen associated with resistance to infection mainly in the IgA isotype, which is of prominent importance for infection by pathogens via the mucosal route. We studied healthy individuals with long-term exposure to tuberculosis, infected (TST+) and uninfected TST−) with M. tuberculosis. From a total of 22 V genes analysed, the TST− population preferred the VH3-23 and Vκ1 genes. The VH3-23 genes were subsequently subjected to 454 amplicon sequencing. The TST− population showed a higher frequency of the D3-10 segment compared with the D3-22 segment for the TST+ population. The J segment usage pattern was similar for both populations with J4 segment being used the most. A preferential pairing of J4 segments to D3-3 was seen for the TST− population. The antibodyome difference between both populations suggests a preference for antibodies with VH3-23, D3-3, JH4 gene usage by the TST− population that could be associated with resistance to infection with M. tuberculosis. 相似文献