Gestational trophoblastic tumor in pregnancy: a case report and review of the literature

A case of gestational trophoblastic tumor (GTT) concurrent with an intrauterine pregnancy is reported in a 21-year-old gravida 2 para 0 (0010) who presented with dyspnea, orthopnea, headache, and blurring of vision at 33 weeks age of gestation. She had a history of hydatidiform mole for which curettage was done. Chest radiograph showed pulmonary metastases, with pleural effusion on both lungs. Serum beta subunit of human chorionic gonadotropin was abnormally elevated for age of gestation. Due to worsening maternal pulmonary condition, the patient underwent primary, low segment cesarean section and was subsequently started on multidrug chemotherapy. This is the first reported case of GTT in pregnancy in the Philippines in which both the mother and the infant survived. Several hypotheses regarding its origin, its diagnosis, and its management and prognosis are presented. This case report emphasizes the importance of early diagnosis and treatment to improve the prognosis of both the mother and the infant.     

尽力减少非甾体类抗炎药对胃十二指肠的副作用

阿司匹林问世已届百年，这是一种多年来常用的镇痛解热药。５０年代初保泰松问世后，非甾体类抗炎药（ＮＳＡＩＤ）逐渐应用于临床治疗风湿病和骨关节炎等。１９６０年以来，许多新型结构和剂型的ＮＳＡＩＤ相继合成，至今已有５０多种在世界市场上销售，例如吲哚美辛、舒...     

尼莫地平片剂生物利用度和健康人药代动力学研究

用高效液相色谱法测定了6名健康志愿者口服二种尼莫地平片剂的相对生物利用度和药代动力学参数。结果表明:尼莫地平在人体内的浓度—时间数据可用一室开放模型拟合,主要动力学参数与国外文献报道一致。新片剂和普通片的人体相对生物利用度分别为82.39%和16.01%。     

氢化阿托酸在大鼠体内时间药代动力学参数的立体选择性

研究了氢化阿托酸在大鼠体内的立体选择药代动力学参数,结果表明,在标准明暗周期下,T_1/2α和CL具有立体择性,而反相明暗周期下,有立体选择性的药代动力学参数为T_1/2β,AUC,CL,Vc和MRT。比较两种明暗周期各相应参数,除极少数几个参数外,都无显著差异。     

Comparison of growth rates of bovine retinal and brain microvascular pericytes in different oxygen concentrations in vitro

Background: The hyperoxic injury of the microcirculation in the central nervous system appears to be specific to the retina in premature mammals. Oxygen tensions in normal adult mammalian retina and brain vary between nearly 0 and 90 mmHg. This study sought to compare the in vitro replication of retinal and brain microvascular pericytes in normal glucose medium and in 1 %, 5% and 20% oxygen (equivalent to 15 mmHg, 35 mmHg and 150 mmHg, respectively).
Methods: A preliminary study, using oxygen micro-electrodes, confirmed that the pericellular oxygen tension of pericytes, cultured in medium under air, was within 13 mmHg of the tension of the gas phase above the media.
Pericytes were highly enriched by magnetic antibody cell sorting with the anti-pericyte monoclonal antibody (3G5) to 95% to 99% purity, to remove cell contaminants which may have invalidated the mitogenic assay.
Results: Mitogenic assays showed that brain pericytes replicated faster than their counterparts from retina (f< 0.0001, averaged for data from all culture conditions using three-way ANOVA). Reduction of oxygen tension from 150 to 15 mmHg led to significantly increased replication of retinal pericytes ( P =0.01), but an insignificant increase for brain pericytes.
Conclusions: We have found that pericytes from the brain and retina cultured conventionally in fetal calf serum consume a relatively low amount of oxygen. Decreasing the oxygen tension to 1% (15 to 20 mmHg) increased the replication of retinal pericytes but not brain pericytes in normal glucose concentrations and in fetal calf serum. That retinal pericyte replication is sensitive to variation in oxygen tensions, indicates that the retinal microvascular cells have a unique biological response. This growth sensitivity to oxygen may be important in the pathogenesis of retinopathy of prematurity.