全文获取类型
收费全文 | 17479篇 |
免费 | 737篇 |
国内免费 | 79篇 |
专业分类
耳鼻咽喉 | 205篇 |
儿科学 | 292篇 |
妇产科学 | 187篇 |
基础医学 | 2134篇 |
口腔科学 | 551篇 |
临床医学 | 1097篇 |
内科学 | 4064篇 |
皮肤病学 | 218篇 |
神经病学 | 1432篇 |
特种医学 | 737篇 |
外科学 | 3123篇 |
综合类 | 65篇 |
预防医学 | 558篇 |
眼科学 | 225篇 |
药学 | 1202篇 |
中国医学 | 25篇 |
肿瘤学 | 2180篇 |
出版年
2023年 | 79篇 |
2022年 | 139篇 |
2021年 | 268篇 |
2020年 | 156篇 |
2019年 | 184篇 |
2018年 | 282篇 |
2017年 | 192篇 |
2016年 | 252篇 |
2015年 | 262篇 |
2014年 | 378篇 |
2013年 | 440篇 |
2012年 | 737篇 |
2011年 | 735篇 |
2010年 | 482篇 |
2009年 | 413篇 |
2008年 | 714篇 |
2007年 | 703篇 |
2006年 | 743篇 |
2005年 | 772篇 |
2004年 | 743篇 |
2003年 | 733篇 |
2002年 | 769篇 |
2001年 | 775篇 |
2000年 | 775篇 |
1999年 | 705篇 |
1998年 | 247篇 |
1997年 | 189篇 |
1996年 | 187篇 |
1995年 | 133篇 |
1994年 | 108篇 |
1993年 | 106篇 |
1992年 | 464篇 |
1991年 | 408篇 |
1990年 | 372篇 |
1989年 | 457篇 |
1988年 | 375篇 |
1987年 | 332篇 |
1986年 | 357篇 |
1985年 | 337篇 |
1984年 | 248篇 |
1983年 | 157篇 |
1982年 | 73篇 |
1979年 | 144篇 |
1978年 | 100篇 |
1977年 | 86篇 |
1975年 | 80篇 |
1974年 | 75篇 |
1973年 | 75篇 |
1969年 | 92篇 |
1967年 | 87篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
102.
S Sasaki H Yoshida Y Matsui M Sakuma K Yasuda T Tanabe H Chouji 《Kyobu geka. The Japanese journal of thoracic surgery》1990,43(2):106-113
The diagnostic value of cine magnetic resonance imaging (cine-MRI) was evaluated in 10 patients with disease of great vessels. The parameters necessary to decide the appropriate treatment, such as presence and extension of intimal flap, DeBakey type classification, identification of the entry, differentiation between true and false lumen, and between thrombosis and slow flow were demonstrated in all patients with dissecting aortic aneurysm. However, abdominal aortic branches could not be demonstrated enough by cine-MRI, therefore conventional AOG was necessary to choose the operative procedure in these cases. In patients with thoracic aortic aneurysm (TAA), cine-MRI was valuable in demonstrating both blood flow and thrombus in the lumen of aneurysm, and AOG was thought to be unnecessary in most cases. Cine-MRI is a promising new technique for the evaluation of diseases of great vessels. 相似文献
103.
104.
Synchronous pulmonary atypical adenomatous hyperplasia and metastatic osteosarcoma in a young female
Ken Kodama Masahiko Higashiyama Koji Takami Naozumi Higaki Kazuyuki Oda Nobuhito Araki 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(7):357-359
A 17-year-old female underwent metastasectomy of three synchronous lesions in the bilateral lungs under the diagnosis of metastatic
osteosarcoma, however, one of them was found to be atypical adenomatous hyperplasia (AAH). Since AAH is very rare among young
people, a careful evaluation of high-resolution computed tomographic image is important in determining the operative indications
and procedures in patients with multiple metastatic tumors. 相似文献
105.
T Motohiro Y Yoshinaga H Sasaki K Oda M Aramaki A Kawakami K Tanaka T Koga Y Shimada Y Sakata 《The Japanese journal of antibiotics》1989,42(2):465-494
It has been known that clarithromycin (TE-031, A-56268), a new macrolide antibiotic (ML), achieves higher concentrations in blood, is better excreted into urine and is better distributed into various tissues than conventional MLs. We investigated the pharmacokinetics of TE-031 in children upon oral administration of the drug in the following method. TE-031 granular preparation with a potency of 100 mg/g was given to 6 boys (5 years 4 months-14 years 0 month) with dose levels of 5 mg/kg and 10 mg/kg for each 3 boys. A tablet preparation with each tablet containing 50 mg of TE-031 was administered to 4 boys and 2 girls (8 years 5 months-11 years 6 months) with dose level of 2 tablets (i.e., 100 mg) and 3 tablets (i.e., 150 mg) for each 3 children. All administrations were done at 30 minutes before meal. Then, to conduct a cross-over test, the granule preparation was given orally to the 3 children mentioned above who was given 2 tablets and the 1 of 3 cases that were given 3 tablets at the same dose levels (100 mg and 150 mg) respectively. A bioassay was used to determine concentrations in blood of active antibiotic compounds and an high performance liquid chromatography (HPLC) was used to determine unchanged TE-031 and its main metabolite, M-5. Urinary concentrations of active antibiotic compounds were also determined by the bioassay and the HPLC was used to determine concentrations and proportions of unchanged TE-031 and its metabolites, M-1, M-4, M-5, M-6 and M-7 to figure out the urinary recovery rate in the first 6 hours. The results of these experiments are summarized as follows. 1. As was mentioned above, TE-031 was administered orally to 2 groups of children at dose levels of 5 mg/kg and 10 mg/kg, respectively. Mean serum levels of total active antibiotic compounds reached their maximum in 1 and 2 hours for the 5 mg/kg and the 10 mg/kg dosage groups, respectively, at 1.28 and 3.62 micrograms/ml, respectively. Mean half lives of serum concentrations in the 2 groups were quite similar, with values of at 2.1 and 2.0 hours, respectively. Mean serum concentrations of unchanged TE-031 determined by the HPLC method reached their peaks in 1 hour after administration in either of the 5 and 10 mg/kg dosage groups at peak levels of 0.65 micrograms/ml and 2.67 micrograms/ml, respectively. Thus, dose-response relationships were observed with TE-031 and M-5.(ABSTRACT TRUNCATED AT 400 WORDS) 相似文献
106.
Yoshito Matsui Tomoatsu Kimura Noriyuki Tsumaki Haruhiko Nakahara Nobuhito Araki Natsuo Yasui Takahiro Ochi 《Journal of orthopaedic science》1996,1(2):130-135
Recent DNA studies performed by several groups have detected mutations of the gene encoding fibroblast growth factor receptor
3 (FGFR3) in patients with achondroplasia-group disorders, including achondroplasia (ACH), hypochondroplasia (HCH), and thanatophoric
dysplasia (TD). For this study, we analyzed theFGFR3 gene in 31 Japanese patients with typical ACH, four with HCH, three with a condition intermediate between ACH and HCH (ACH/HCH-intermediate),
and one with TD. Of the 31 typical ACH patients, 29 showed a G1138 to A transition and the other two a G1138 to C transversion,
both resulting in a common Gly380Arg substitution in the transmembrane domain of FGFR3. The one TD and the four HCH patients
did not display any mutations in the transmembrane domain of FGFR3. Of the three ACH/HCH-intermediate cases, one patient showed
the Gly380Arg substitution and one did not, and further analysis of the second patient revealed the presence of Asn540Lys
substitution. The first patient was, therefore, genotypically diagnosed as ACH and the second as HCH. Peripheral blood leukocyte
DNA analysis in the remaining ACH/HCH-intermediate patient indicated an unequal ratio of mutant to normal PCR products, possibly
representing a somatic mosaic for the Gly380Arg mutation. Analysis of the common FGFR3 mutation thus appears to help in the
molecular diagnosis of patients with achondroplasia-group disorders. 相似文献
107.
Seiji Kinugasa Shuichi Tachibana Manpei Kawakami Tatsuhiko Orino Ryuichi Yamamoto Shinjiro Sasaki 《Surgery today》1998,28(3):335-338
(Received for publication on Nov. 14, 1996; accepted on May 12, 1997) 相似文献
108.
T. Ishikawa T. Yagi H. Sadamori N. Ishine H. Sasaki M. Oishi N. Tanaka 《Transplant international》1998,11(S1):S410-S416
Abstract This study was designed to investigate the effects of differences in the route of nutritional support of the donor on cold ischemia/reperfusion injury. Participation of Kupffer cells in these effects, based on the analysis of hepatic energy metabolism in early phases of reperfusion was also investigated. Orthotopic liver transplantation was performed between Large-White pigs weighing 20–30 kg after a 4-h cold preservation of the graft in Euro-Collins solution at 4°C. One group was fed orally with a standard laboratory diet (FED group, n = 5), a second group was fasted and given 20% glucose intravenously (12 kJ/kg per day) (PEF group, n = 5), and a third group was fed orally with a standard laboratory diet and given GdCI3 (10 mg/kg) intravenously 24 h before operation (FEDGD group, n = 5). These treatments were given for 7 days prior to harvesting. The survival time was significantly longer in the PEF (34.8 ± 5.5 days) and FEDGD (28.0 ± 11.9 days) groups than in the FED (9.8 ± 2.0 days) group ( P < 0.05). The serum hyaluronic acid elimination rate determined from 1 to 2 h after reperfusion was significantly lower in the FED group than in the other two groups ( P < 0.001). The glycogen content of the livers 1 h after reperfusion in all three groups had been consumed rapidly, but the ATP content of the livers was significantly reduced in the FED group alone ( P < 0.01). Hepatic FFA clearance (CFFA ) was moderately increased in all three groups in the early phase after reperfusion, but it was higher in the FED group than in the other two groups, with significant differences 1 and 2 h after reperfusion ( P < 0.05). In conclusion, parenteral nutrition of the donors reduced cold ischemia/reperfusion injury which is related to Kupffer cell activation and, thus, was better than enteral nutrition for donor management. 相似文献
109.
We have designed a new instrument that we have called a skull punch, which is useful and safe for making a burr hole for a purely osteoplastic craniotomy in neonates and infants. The instrument is described in detail. 相似文献
110.
M Matsui T Sasaki K Morita Y Mochizuki Y Yata T Arai 《[Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai》1989,37(11):2382-2386
Calcified stenotic aortic valve are usually replaced by the artificial valve. Recently, we are trying to decalcify the calcification of the aortic valve by ultrasonic energy. This case report reviewed a small physique, 47 year old female, who had the calcified stenotic bicuspid aortic valve and the narrow aortic valve ring (18 mm diameter). The ultrasonic decalcification was performed by the ultrasonic surgical instrument, SUS-201D (ALOKA), ultrasonic energy output range from 25% to 45%. After the ultrasonic decalcification, the movability of the aortic cusps were improved and the aortic opening was enlarged. The systolic pressure gradient across the aortic valve was improved from 100 mmHg to 20 mmHg. This method "ultrasonic decalcification" is very useful technique for the repair of the calcified aortic valve stenosis. 相似文献