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101.
102.
Yuko Hayashi Nobuhiro Suzumori Tokio Sugiura Mayumi Sugiura‐Ogasawara 《Congenital anomalies》2015,55(3):161-163
Holoprosencephaly (HPE) is a rare brain abnormality characterized by an incomplete cleavage of the primitive prosencephalon of forebrain during early embryogenesis. To determine the clinical characteristics and outcome of fetuses with HPE, we retrospectively analyzed nine patients who were prenatally diagnosed as fetal HPE by ultrasounds. The mean diagnostic weeks were 20 weeks of gestation. Two cases died within one day after birth. The chromosomal examinations were performed in seven cases (trisomy 18: n = 2; trisomy 13: n = 2; 45,XX,der(18)t(18;21)(p10;p10)mat: n = 1; normal karyotype: n = 2). In our HPE cases, most cases had serious facial anomalies and poor prognosis. Our data suggested that the early prenatal diagnosis of HPE allowed time for parental counseling and delivery planning. 相似文献
103.
104.
T Hirano P Prunet H Kawauchi A Takahashi T Ogasawara J Kubota R S Nishioka H A Bern K Takada S Ishii 《General and comparative endocrinology》1985,59(2):266-276
A highly specific radioimmunoassay (RIA) for the measurement of prolactin (PRL) in the plasma and pituitary of salmonid fishes was developed using a rabbit antiserum to chinook salmon (Oncorhynchus tschawytscha) PRL. The PRLs purified from chinook salmon and chum salmon (O. keta) pituitaries showed exactly the same competitive inhibition curves in the RIA, regardless of iodination of either hormone. The displacement curves for pituitary extracts and plasma from several salmonids, including chum, coho, and amago salmon, rainbow trout, and Japanese charr, were parallel to the salmon PRL standard, whereas those from the eel, goldfish, carp, and tilapia showed negligible cross-reactivity. Negligible cross-reactivity was also seen with plasma from hypophysectomized rainbow trout or coho salmon. None of the mammalian PRL or growth hormone (GH) preparations, bullfrog PRL, or presumptive chum salmon "gonadotropin" and eel "PRL" cross-reacted in the PRL RIA. Presumptive chum salmon GH showed less than 0.05% cross-reactivity. The RIA sensitivity was less than 0.1 ng of the salmon PRL standard per milliliter. The immunoreactive plasma PRL levels in mature chum salmon were below 1 ng/ml in seawater. The plasma PRL in females increased to about 8 ng/ml 1 day after transfer to fresh water, and high levels (2-4 ng/ml) were maintained during 3-7 days after the transfer. In contrast, when males were transferred to fresh water, an increase in plasma PRL was seen only 1 day after the transfer. A significant decrease in plasma osmolality was observed in both males and females after transfer to fresh water. No change was observed either in plasma PRL or osmolality, when fish were transferred from seawater to seawater. 相似文献
105.
Maejima Y Ueba H Kuroki M Yasu T Hashimoto S Nabata A Kobayashi N Ikeda N Saito M Kawakami M 《Atherosclerosis》2003,167(1):89-95
Hepatocyte growth factor (HGF) is a potent mitogen for vascular endothelial cells (EC); however, signal transduction pathways for HGF-stimulated EC growth remain unclear. In the present study we investigated the role of Src family kinases and nitric oxide (NO) in HGF-stimulated EC growth. Human umbilical vein endothelial cells (HUVEC) were stimulated with HGF and NO was measured by an NOx analyzing HPLC system. Activation of ERK1/2 and p38 MAPK was assessed by Western blot. NO production in HUVEC increased 1.8-fold by HGF. A Src family kinases inhibitor PP1 inhibited HGF-stimulated NO production by 71%. HUVEC growth increased 1.9-fold in cell number by HGF. PP1 and Nitro-L-arginine methylester (L-NAME) inhibited HGF-stimulated HUVEC growth by 51 and by 71%. ERK1/2 and p38 MAPK were phosphorylated by HGF and a MEK inhibitor PD98059 and a p38 MAPK inhibitor SB203580 inhibited HGF-stimulated HUVEC growth by 66% and by 58%; however, HGF-induced phosphorylation of ERK1/2 and p38 MAPK was not inhibited by L-NAME, indicating that NO is not an upstream activator of ERK1/2 and p38 MAPK. These findings demonstrated that Src family kinases regulate HGF-stimulated NO production in HUVEC and that HGF stimulates HUVEC growth through NO-dependent and NO-independent pathways. 相似文献
106.
Akihiko Ohwatashi Satoshi Ikeda Katsuhiro Harada Yurie Kamikawa Akira Yoshida Kazuhiro Inoue Nobuhiko Yanagida Kiyohiro Fukudome Ryoji Kiyama Tadasu Ohshige Tetsuo Maeda 《Journal of Physical Therapy Science》2015,27(1):205-208
[Purpose] This study aimed to use a thermograph to observe temperature changes caused by
different distances between an ultrasound transducer and bone during 1 MHz and 3 MHz
continuous ultrasound emission on a phantom. [Materials and Methods] We observed the
distribution of temperature elevations on a phantom consisting of pig ribs and
tissue-mimicking material. One megahertz and 3 MHz ultrasound were delivered at
2.0 W/cm2 for 5 minutes. To record the temperature changes on the phantom, we
took a screenshot of the thermograph with a digital camera every 20 seconds. [Results]
With 1 MHz ultrasound at the distances of 2 and 3 cm, the temperature elevation near the
bone was higher than that near the transducer. However, with 3 MHz ultrasound, the
temperature elevation was higher near the transducer rather than near the bone. At this
point, we consider that there is a possibility of heat injury to internal organs in spite
of there being no elevation of skin temperature. [Conclusion] When performing ultrasonic
therapy, not only should the frequency be taken into consideration, but also the influence
of the absorption coefficient and the reflection of the tissue. We visually confirmed the
thermal ultrasound effect by thermography. Special attention to the temperature elevation
of the internal organs is necessary to avoid injuries.Key words: Ultrasound, Thermal effect, Thermography 相似文献
107.
Olmesartan ameliorates insulin sensitivity by modulating tumor necrosis factor-alpha and cyclic AMP in skeletal muscle. 总被引:2,自引:0,他引:2
Koichi Yamaguchi Nobuyuki Ura Hideyuki Murakami Nobuhiko Togashi Masaya Hyakukoku Katsuhiro Higashiura Kazuaki Shimamoto 《Hypertension research》2005,28(9):773-778
We have reported that tumor necrosis factor (TNF)-alpha in skeletal muscle is one of the determinants of insulin resistance and that the renin-angiotensin system may be related to the regulation of TNF-a in skeletal muscle. Recent studies have suggested the involvement of cyclic adenosine monophosphate (cAMP) in the regulation of TNF-a in vascular smooth muscle cells or monocytes. The aim of this study was to determine the relationship between cAMP and TNF-a in skeletal muscle in connection with the renin-angiotensin system. Six-week-old male Sprague-Dawley rats were fed either normal rat chow or fructose-rich chow for 6 weeks. For the last 2 weeks of a 6-week period, the rats were treated with a vehicle or with an angiotensin II type 1 receptor antagonist (olmesartan medoxomil, 0.1 mg/kg/day). TNF-alpha levels in the soleus muscle were significantly higher and cAMP levels in the soleus muscle were significantly lower in fructose-fed rats than in control rats. Olmesartan increased cAMP and reduced TNF-a simultaneously in fructose-fed rats. There was a significant negative correlation between levels of cAMP and TNF-alpha. Moreover, a cAMP analogue reduced TNF-a levels in the soleus muscle. These results indicate that the increase in TNF-alpha via suppression of cAMP may affect the induction of insulin resistance. In addition, the facts that olmesartan increased cAMP and decreased TNF-alpha suggest that a part of the TNF-alpha regulation by angiotensin II might consist of modulation of cAMP through Gi protein activation in skeletal muscle. 相似文献
108.
Eiji Masuda Sunao Kawano Kouichi Nagano Shingo Tsuji Yoshitaka Ishigami Nobuhiko Hayashi Masahiko Tsujii Yoshiaki Sasayama Tomoki Michida Hideyuki Fusamoto et al. 《Journal of gastroenterology》1991,26(Z3):81-82
The effects of ethanol on gastric vasculature in isolated vascularly perfused rabbit stomach was investigated. The isolated
stomach was perfused with Krebs-Henseleit solution containing 3% dextran bubbled with 95% O2 and 5% CO2 at a rate of 12 ml/min. After mixture and perfusion of 10 mM to 400 mM of ethanol, perfusion pressure and endothelin-1 concentration
in effluent from gastric vasculature were measured. Perfusion pressure and endothelin-1 concentration in effluent increased
in a dose-dependent manner with increasing ethanol concentrations. In conclusion, the data suggest that ethanol may stimulate
the release of endothelin from gastric vasculature and may cause gastric ischemia due to vasoconstriction resulting in acute
gastric mucosal injury. 相似文献
109.
Tadanori Aizawa MD Ken Ogasawara MD Fumitaka Nakamura MD Akira Hirosaka MD Tohru Sakuma MD Kazuyuki Nagashima MD Kazuzo Kato MD 《The American journal of cardiology》1989,63(21):J75-J79
In patients in whom dynamic coronary obstruction plays a predominant role in the pathogenesis of angina pectoris, dilatation of large coronary arteries and relief of coronary spasm account for the main mechanism of action of antianginal drugs. In this study, the acute vasodilating effects of nicorandil, a newly developed antianginal drug, were assessed in 10 patients who had spontaneous and ergonovine-evoked coronary spasms. The prompt, complete relief of both spontaneous and evoked coronary spasms was obtained in all of 10 patients with nicorandil. The coronary spasmolytic effect of nicorandil in the present series is thus considered to be beneficial to the treatment of coronary spasm. 相似文献
110.