全文获取类型
收费全文 | 436篇 |
免费 | 37篇 |
专业分类
儿科学 | 40篇 |
妇产科学 | 13篇 |
基础医学 | 40篇 |
口腔科学 | 4篇 |
临床医学 | 41篇 |
内科学 | 122篇 |
皮肤病学 | 26篇 |
神经病学 | 11篇 |
特种医学 | 2篇 |
外科学 | 66篇 |
综合类 | 7篇 |
预防医学 | 32篇 |
眼科学 | 16篇 |
药学 | 32篇 |
中国医学 | 1篇 |
肿瘤学 | 20篇 |
出版年
2024年 | 1篇 |
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 24篇 |
2020年 | 11篇 |
2019年 | 14篇 |
2018年 | 23篇 |
2017年 | 18篇 |
2016年 | 25篇 |
2015年 | 24篇 |
2014年 | 43篇 |
2013年 | 36篇 |
2012年 | 59篇 |
2011年 | 58篇 |
2010年 | 24篇 |
2009年 | 21篇 |
2008年 | 21篇 |
2007年 | 13篇 |
2006年 | 9篇 |
2005年 | 17篇 |
2004年 | 12篇 |
2003年 | 5篇 |
2002年 | 3篇 |
1999年 | 1篇 |
排序方式: 共有473条查询结果,搜索用时 0 毫秒
471.
Joyeeta Chowdhury Pijush Kanti Datta Satyendra Nath Chowdhury Nilay Kanti Das 《Indian journal of dermatology》2016,61(3):288-294
Background:Pemphigus is a group of chronic autoimmune vesico-bullous disorders in which the epidermis and the basement membrane zone are the focus of attack resulting in cutaneous and mucosal blister formation. Direct immunofluorescence (DIF) test is a very sensitive test for the diagnosisAim:To study the clinico histopathological patterns of pemphigus in eastern India. The study also aims to correlate DIF with clinical and histologic findings as well as severity of skin involvement [scoring systems].Results:In our study Pemphigus vulgaris (PV) was the predominant type with 32 cases followed by 8 cases of pemphigus foliaceus (PF) and a single case of IgA pemphigus. Mean age at presentation was late middle age. Majority of the patients, 26 (63.41%) initially had cutaneous involvement followed by mucosal involvement. In this study group 36 (87.80%) patients showed acantholytic cells on histopathological examination. Most patients of PV showed suprabasal blister 20 (62.50%) followed by intraspinous 5 (15.62%) and subcorneal 5 (15.62%) blister. In majority 28 (87.50%) of the PV patients IgG and C3 antibodies were deposited throughout the epidermis. The strength of antibody positivity was strong in most of the patients (71.87%). In cases of PF mostly IgG 6 (75%) antibodies were deposited in the upper epidermis. DIF intensity had poor correlation with disease activity/severity except in PF.Conclusion:Almost 85.36% cases of pemphigus were diagnosed clinicopathologically. But 6 cases couldn’t be diagnosed accurately on clinicopathological basis and in them DIF was confirmatory. Two cases of pure mucosal PV and 1 case of IgA pemphigus was confirmed by DIF. Two cases of bullous pemphigoid clinico-histologically mimicking PV were also excluded by DIF. So it appears from our study that DIF is confirmatory for diagnosis of pemphigus in all cases. 相似文献
472.
Nilay Duman Reşat Duman Murat Tosun Murat Akıcı Engin Göksel Barış Gökçe Oğuzhan Alagöz 《Advances in medical sciences》2018,63(2):347-352
Purpose
Folic acid is an essential vitamin participating in DNA synthesis and repair. Recently folic acid has been shown to stimulate DNA-repair capacity in dermal fibroblasts in response to injury. Thus, the present study aimed to investigate the effects of topical folinic acid, a 5-formyl derivative of tetrahydrofolic acid, on wound healing using rat wound model.Materials and methods
A rat wound model was established, and the wound healing was evaluated by macroscopic and histological analyses among vehicle control, 2.5% folinic acid, 1% folinic acid, and dexpanthenol treatment groups. While an image-analysis program was used to evaluate macroscopic wound closure, connective tissue properties, mast cell numbers, and the expressions of matrix metalloproteinase 1 (MMP-1) and 9 (MMP-9) were evaluated by microscopy.Results
The 2.5% folinic acid-treated group exhibited enhanced wound healing by increased reepithelialization, neo-vessel formation, inflammatory cell migration, collagen deposition and progressive mast cell increase. Furthermore, 2.5% folinic acid induced higher expressions of MMP-1 and MMP-9.Conclusions
Folinic acid enhances both macroscopic and microscopic wound healing in rat wound model. 相似文献473.