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排序方式: 共有529条查询结果,搜索用时 15 毫秒
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Lerato L. Mokoloko Joyce B. Matsoso Nikolas Antonatos Vlastimil Maznek Beatriz D. Moreno Roy P. Forbes Dean H. Barrett Zdenk Sofer Neil J. Coville 《RSC advances》2022,12(33):21440
The application of N-doped carbon nanosheets, with and without embedded carbon dots, as active materials for the room temperature chemoresistive detection of methanol and/or ethanol is presented. The new carbons were made by converting 0D N-doped carbon dots (NCDs) to 2D nitrogen-doped carbon nanosheets by heat treatment (200–700 °C). The nanosheets exhibited a lateral size of ∼3 μm and a thickness of ∼12 nm at the highest annealing temperature. Both Raman and TEM analyses showed morphological transitions of the dots to the sheets, whilst XPS analysis revealed transformation of the N-bonding states with increasing temperature. PDF analysis confirmed the presence of defective carbon sheets. Room temperature screening of the chemical vapours of two alcohols (methanol and ethanol), revealed that the structure and the type of N-configuration influenced the detection of the chemical vapours. For instance, the lateral size of the nanosheets and the high charge density N-configurations promoted detection of both methanol and ethanol vapours at good sensitivity (−16.8 × 10−5 ppm−1EtOH and 1.2 × 10−5 ppm−1MeOH) and low LoD (∼44 ppmEtOH and ∼30.3 ppmMeOH) values. The study showed that the composite nature as well as the large basal area of the carbon nanosheets enabled generation of adequate defective sites that facilitated easy adsorption of the VOC analyte molecules, thereby eliminating the need to use conducting polymers or the formation of porous molecular frameworks for the alcohol detection.2D layered carbon nanostructures made by annealing 0D carbon dots, have been used as ethanol/methanol sensors. 相似文献
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Veldhuizen Gregory Patrick Röcken Christoph Behrens Hans-Michael Cifci Didem Muti Hannah Sophie Yoshikawa Takaki Arai Tomio Oshima Takashi Tan Patrick Ebert Matthias P. Pearson Alexander T. Calderaro Julien Grabsch Heike I. Kather Jakob Nikolas 《Gastric cancer》2023,26(5):708-720
Gastric Cancer - The Laurén classification is widely used for Gastric Cancer (GC) histology subtyping. However, this classification is prone to interobserver variability and its prognostic... 相似文献
525.
Pradeep Kumar Patnana Longlong Liu Daria Frank Subbaiah Chary Nimmagadda Matthias Behrens Helal Ahmed Xiaoqing Xie Marie Liebmann Lanying Wei Andrea Gerdemann Aniththa Thivakaran Hans-Ulrich Humpf Luisa Klotz Martin Dugas Julian Varghese Marija Trajkovic-Arsic Jens T. Siveke Helmut Hanenberg Bertram Opalka Ulrich Dührsen Hans Christian Reinhardt Ulrich Guenther Nikolas von Bubnoff Cyrus Khandanpour 《British journal of haematology》2023,202(5):1033-1048
526.
Robotic system for magnetic resonance imaging-guided focused ultrasound treatment of thyroid nodules
Antria Filippou Nikolas Evripidou Christakis Damianou 《The international journal of medical robotics + computer assisted surgery : MRCAS》2023,19(5):e2525
Background
Herein, a robotic system offering Magnetic Resonance-guided Focused Ultrasound (MRgFUS) therapy of thyroid nodules was developed.Methods
The robotic system offers linear motion in 2 PC-controlled axes that navigate a 3 MHz single-element focused transducer. The system, through a C-arm structure attaches to the table of Magnetic Resonance Imaging (MRI) scanners and couples to the neck of patients lying in the supine position. The MRI compatibility of the developed system was assessed inside a 3 T scanner. Benchtop and MRI feasibility studies evaluating the heating performance of the system were executed on excised pork tissue and on homogeneous and thyroid model agar-based phantoms.Results
The MRI compatibility of the system was successfully established. Grid sonications executed using robotic motion inflicted discrete and overlapping lesions on the excised tissue, while magnetic resonance (MR) thermometry successfully monitored thermal heating in agar-based phantoms.Conclusions
The developed system was found to be efficient with ex-vivo evaluation. The system can perform clinical MRgFUS therapy of thyroid nodules and other shallow targets after further in-vivo evaluation. 相似文献527.
Alissa Becerril BA Elizabeth R. Pfoh PhD Ardeshir Z. Hashmi MD Lyla Mourany MS Douglas D. Gunzler PhD Kristen A. Berg PhD Nikolas I. Krieger MS Kamini Krishnan PhD Scott Emory Moore PhD APRN Eva Kahana PhD Neal V. Dawson MD Lorella Luezas Shamakian MD James W. Campbell MD Adam T. Perzynski PhD Jarrod E. Dalton PhD 《Journal of the American Geriatrics Society》2023,71(8):2406-2418
Background
Evidence on the effects of neighborhood socioeconomic disadvantage on dementia risk in racially and ethically diverse populations is limited. Our objective was to evaluate the relative extent to which neighborhood disadvantage accounts for racial/ethnic variation in dementia incidence rates. Secondarily, we evaluated the spatial relationship between neighborhood disadvantage and dementia risk.Methods
In this retrospective study using electronic health records (EHR) at two regional health systems in Northeast Ohio, participants included 253,421 patients aged >60 years who had an outpatient primary care visit between January 1, 2005 and December 31, 2015. The date of the first qualifying visit served as the study baseline. Cumulative incidence of composite dementia outcome, defined as EHR-documented dementia diagnosis or dementia-related death, stratified by neighborhood socioeconomic deprivation (as measured by Area Deprivation Index) was determined by competing-risk regression analysis, with non-dementia-related death as the competing risk. Fine-Gray sub-distribution hazard ratios were determined for neighborhood socioeconomic deprivation, race/ethnicity, and clinical risk factors. The degree to which neighborhood socioeconomic position accounted for racial/ethnic disparities in the incidence of composite dementia outcome was evaluated via mediation analysis with Poisson rate models.Results
Increasing neighborhood disadvantage was associated with increased risk of EHR-documented dementia diagnosis or dementia-related death (most vs. least disadvantaged ADI quintile HR = 1.76, 95% confidence interval = 1.69–1.84) after adjusting for age and sex. The effect of neighborhood disadvantage on this composite dementia outcome remained after accounting for known medical risk factors of dementia. Mediation analysis indicated that neighborhood disadvantage accounted for 34% and 29% of the elevated risk for composite dementia outcome in Hispanic and Black patients compared to White patients, respectively.Conclusion
Neighborhood disadvantage is related to the risk of EHR-documented dementia diagnosis or dementia-related death and accounts for a portion of racial/ethnic differences in dementia burden, even after adjustment for clinically important confounders. 相似文献528.
Nikolas Heim MA MSc Marina Bobou MSc Michal Tanzer PhD Paul M. Jenkinson PhD Christiane Steinert PhD Aikaterini Fotopoulou PhD 《Psychiatry and clinical neurosciences》2023,77(10):530-540
Disturbed interoception (i.e., the sensing, awareness, and regulation of internal body signals) has been found across several mental disorders, leading to the development of interoception-based interventions (IBIs). Searching PubMed and PsycINFO, we conducted the first systematic review of randomized-controlled trials (RCTs) investigating the efficacy of behavioral IBIs at improving interoception and target symptoms of mental disorders in comparison to a non-interoception-based control condition [CRD42021297993]. Thirty-one RCTs fulfilled inclusion criteria. Across all studies, a pattern emerged with 20 (64.5%) RCTs demonstrating IBIs to be more efficacious at improving interoception compared to control conditions. The most promising results were found for post-traumatic stress disorder, irritable bowel syndrome, fibromyalgia and substance use disorders. Regarding symptom improvement, the evidence was inconclusive. The IBIs were heterogenous in their approach to improving interoception. The quality of RCTs was moderate to good. In conclusion, IBIs are potentially efficacious at improving interoception for some mental disorders. In terms of symptom reduction, the evidence is less promising. Future research on the efficacy of IBIs is needed. 相似文献
529.