全文获取类型
收费全文 | 219篇 |
免费 | 16篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 9篇 |
妇产科学 | 11篇 |
基础医学 | 26篇 |
口腔科学 | 12篇 |
临床医学 | 16篇 |
内科学 | 61篇 |
皮肤病学 | 6篇 |
神经病学 | 21篇 |
特种医学 | 2篇 |
外科学 | 49篇 |
预防医学 | 3篇 |
眼科学 | 5篇 |
药学 | 10篇 |
肿瘤学 | 4篇 |
出版年
2023年 | 4篇 |
2022年 | 6篇 |
2021年 | 15篇 |
2020年 | 9篇 |
2019年 | 11篇 |
2018年 | 12篇 |
2017年 | 9篇 |
2016年 | 10篇 |
2015年 | 12篇 |
2014年 | 14篇 |
2013年 | 5篇 |
2012年 | 24篇 |
2011年 | 8篇 |
2010年 | 5篇 |
2009年 | 13篇 |
2008年 | 10篇 |
2007年 | 16篇 |
2006年 | 16篇 |
2005年 | 13篇 |
2004年 | 10篇 |
2003年 | 7篇 |
2002年 | 5篇 |
1995年 | 1篇 |
1985年 | 1篇 |
排序方式: 共有236条查询结果,搜索用时 15 毫秒
31.
Olus Api H. Nihan Demır Murat Api Ismet Tamer Ekrem Orbay Orhan Unal 《Archives of gynecology and obstetrics》2009,280(4):553-558
Objective The value of genetic sonogram is controversial in low-risk population. The aim of our study was to compare the anxiety levels
among women with high risk and low risk for fetal chromosomal/structural defects.
Materials and methods A total of 115 consecutive pregnant women were included. The anxiety levels were assessed by the use of Turkish version of
the standardized state-trait-anxiety-inventory. Before and after genetic sonogram, state and trait-anxiety was measured.
Results The mean state anxiety score before genetic sonogram was statistically, significantly higher than the mean score after the
examination. Before genetic sonogram, the mean state-anxiety score of the women with high risk for fetal chromosomal/structural
defects was significantly higher than the mean score of women with low risk. Following genetic sonogram, although the anxiety
scores decreased, the scores of women with high risk still remained significantly higher than the scores of women with low
risk and the anxiety scores significantly further increased among women with a positive minor or major ultrasound finding.
Conclusion Genetic sonogram presents an anxiety-inducing situation for the parents-to-be. The level of experienced anxiety was found
to be proportional to the level of the perceived risk. Women with low risk for chromosomal/structural defects experienced
lower anxiety than women with high risk. Following the examination, women with a negative result were found to have a significant
reduction of anxiety and emotional relief whereas a positive test result led to a further increase in anxiety scores. 相似文献
32.
33.
Yahya Ekici Cem Aydogan Cenk Balcik Nihan Haberal Mahir Kirnap Gokhan Moray Mehmet Haberal 《Indian Journal of Plastic Surgery》2012,45(2):215-219
Context:
An animal model.Aim:
We sought to evaluate the effect of static magnetic fields on cutaneous wound healing.Materials and Methods:
Male Wistar rats were used. Wounds were created on the backs of all rats. Forty of these animals (M group) had NeFeB magnets placed in contact with the incisions, either parallel (Pa) and perpendicular (Pr) to the incision. The other 40 animals (sham [S] group) had nonmagnetized NeFeB bars placed in the same directions as the implanted animals. Half of the animals in each group were killed and assessed for healing on postoperative day 7 and the other half on postoperative day 14. The following assessments were done: gross healing, mechanical strength, and histopathology.Statistical Analysis Used:
Intergroup differences were compared by using the Mann-Whitney U or t test. Values for P less than 0.05 were accepted as significant.Results and Conclusions:
There were no differences between the magnetic and sham animals with respect to gross healing parameters. The mechanical strength was different between groups. On postoperative day 14, the MPr14 had significantly higher scores than the other groups. When static, high-power, magnetic fields are placed perpendicular to the wound, increased wound healing occurs in the skin of the experimental model.KEY WORDS: Static electromagnetic field, wound healing, breaking strength, skin 相似文献34.
Arici G Kayacan N Dincer D Karsli B Akce S Cete N Erman M 《Hepato-gastroenterology》2003,50(Z2):cclxxxiii-ccclxxxvi
One of the most commonly performed outpatient procedure is colonoscopy. The pain and anxiety is frequently associated with colonoscopy. The aim of this study was to compare the effectiveness of remifentanil/midazolam, and tramadol/midazolam for iv sedation and analgesia during colonoscopy. Twentysix patients (age range 18-65 years) scheduled for ambulatory colonoscopy were included to study. All patients received midazolam 1 mg intravenous. After two minutes in Group R (remifentanil/midazolam, n=18) remifentanil bolus (10 microg) and infusion 0.03 microg kg(-1) min(-1) were administered until adequate sedation level was achieved. In Group T (tramadol/midazolam, n=18) iv tramadol 50 mg was given concurrently. During procedure 2 L/min oxygen was supplemented via face mask to all patients. Haemodynamic variables, respiratory depression, level of sedation, postoperative recovery, patient and gastroenterologist satisfaction were surveyed. Patients were asked to verbally rate their level of pain, on an 10-point numerical rating scale (1=no pain, 10=severe pain). Chi-square, student t test, and mann whitney U test were used for statistical analysis. Colonoscopy was carried out successfully in all patients. There were no episodes of desaturation or airway compromise. Haemodynamic parameters were similar in both groups. Sistolic arterial and diastolic arterial pressures were increased at 10 and 15 minutes in all patients (P<0.05). There were no significant changes in heart rate in both groups. The level of sedation in group R was higher than group T during colonoscopy. The patients in group T had higher pain scores. Gastroenterologist satisfaction and patient satisfaction were similar in both groups. Our results suggests that, sedoanalgesia with midazolam/remifentanil may be an alternative to sedoanalgesia with midazolam/tramadol for colonoscopy. 相似文献
35.
Erkanli K Kayalar N Erkanli G Ercan F Sener G Kirali K 《Journal of pineal research》2005,39(3):238-242
Abstract: Melatonin has been shown to diminish ischemia-reperfusion (I/R) injury in many tissues. The main aim of this study was to evaluate the protective antioxidant effect of melatonin in skeletal muscle during I/R injury. Wistar albino rats were randomly divided into three groups. Hindlimb ischemia was achieved by clamping the common femoral artery in two groups but not in control group. Limbs were rendered ischemic for 1.5 hr; at the end of the reperfusion period of 1.5 hr muscle tissue samples were taken for the histological evaluation and biochemical analysis. Melatonin (10 mg/kg) was injected i.p. in the I/R + Mel group at the onset of ischemia whereas the vehicle solution was injected in the I/R group. In I/R + Mel group histological damage was significantly less than in the I/R group ( P < 0.001). In the I/R + Mel group, the mean malonedialdehyde level was lower than in the I/R group ( P < 0.01) and was quite near to the levels in the control group ( P > 0.05). Glutathione levels were found to be reduced in the I/R group compared with the control ( P < 0.01) and I/R + Mel group ( P < 0.01). Melatonin has a protective effect against I/R injury in skeletal muscle and may reduce the incidence of compartment syndrome, especially after acute or chronic peripheral arterial occlusions. 相似文献
36.
Turhan N Yürür-Kutlay N Topcuoglu P Sayki M Yüksel M Gürman G Tükün A 《Leukemia research》2006,30(7):903-905
We report a case of AML-M4 in which G-band karyotyping revealed a previously unreported t(13;17)(q14;q25) in metaphase preparations. The breakpoints at 13q14 and 17q25 are associated with poor prognosis. The MSF and FKHR genes are located on 17q25 and 13q14, respectively. This report of AML-M4 harboring t(13;17)(q14;q25) as a unique cytogenetic abnormality provides more data on the leukomogenesis with rearrangements related with 13q14 and 17q25. 相似文献
37.
38.
Lohmann E Guerreiro RJ Erginel-Unaltuna N Gurunlian N Bilgic B Gurvit H Hanagasi HA Luu N Emre M Singleton A 《Neurobiology of aging》2012,33(8):1850.e17-1850.e27
In order to assess the frequency of mutations in the known Alzheimer's disease causative genes in Turkish dementia patients we screened amyloid precursor protein (APP), PSEN1 and PSEN2 for mutations in a cohort of 98 Turkish dementia families. Six families were found to carry PSEN1 mutations (p.H163R, p.P264L, and p.H214Y) or variants suggested to cause the disease (p.L134R, p.L262V, and p.A396T). In 4 other families, previously reported PSEN2 variants were identified (p.R62H, p.R71W, p.M174V (n = 2), and p.S130L). The phenotype of the carriers varied from rapid progressing Alzheimer's disease to frontotemporal dementia, with spasticity and seizures also observed. Here we report a frequency of 11.2% of mutations and variants in the known Alzheimer disease genes in the dementia cohort studied and 24% in the early onset subgroup of patients, suggesting that mutations in these genes are not uncommon in Turkey and are associated with various phenotypes. We thus believe that genetic analysis should become a standardized diagnostic implement, not only for the identification of the genetic disease, but also for appropriate genetic counseling. 相似文献
39.
Kurne A Sayat G Aydin OF Turgutoglu N Terzi M Sackesen C Karabulut E Karabudak R 《Journal of neuroimmunology》2012,250(1-2):83-86
Soluble (s) CD14, being a receptor for lipopolysaccharides (LPSs) may inhibit LPS-triggered apoptosis and T lymphocyte proliferation. C to T exchange at position -159 in the promoter region of the CD14 gene might lead to higher sCD14 levels. Limited number of groups have studied whether these polymorphisms might influence the development of organ specific autoimmunity and whether higher CD14 levels are associated with increased levels of cytokines trigerring inflammatory processes. However their data contradict each other. In this study serum levels of sCD14 based on ELISA were measured in 77 treatment-naive patients and in 67 healthy controls. As the C-159T proximal promoter region regulates sCD14 levels, we investigated whether C-159T polymorphism is related to progression index in 250 MS patients vs. 183 healthy controls. CD14 polymorphism frequency between the healthy controls and the MS patients were not significantly different. While TT genotype of MS patients demonstrated significantly lower sCD14 levels compared to CC genotype; this difference was not reflected on the disease progression index. Our study that extends the prior data of previous studies reflects that sCD14 do not appear to be a solely prominent element of innate immunity in MS. 相似文献
40.
Zehra Aktan Nihan Hande Akcakaya Pinar Tekturk Engin Deniz Bahar Koyuncu Zuhal Yapici 《Neurologia i neurochirurgia polska》2018,52(2):285-288
Charcot-Marie-Tooth (CMT) disease is a hereditary neurologic disease which affects the sensorial and motor fibers of the peripheral nerves. CMTX1 is an X-linked dominantly inherited subtype of CMT and is caused by mutations in gap junction beta 1 gene (GJB1). A small proportion of GJB1 mutations are associated with recurrent central nervous system findings. We describe a 15-year-old male patient with CMTX1 who had stroke-like findings along with foot deformities and peripheral neuropathy. Strokes and stroke-like attacks are rarely seen in children and adolescents. Herein, neurological signs, MRI findings and genetic results of a CMTX1 case are presented and discussed. 相似文献