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Robert C. Knowlton MD Nicholas D. Lawn FRACP James M. Mountz MD PhD Ojha Buddhiwardhan MD Suzanne Miller RN BSN Jorge G. Burneo MD Ruben I. Kuzniecky MD 《Journal of neuroimaging》2004,14(4):324-330
PURPOSE: To examine the application of statistical parametric mapping (SPM) to analyze ictal single-photon emission computed tomography (SPECT) scans in surgical candidates with extratemporal lobe epilepsy. METHODS: The authors selected patients who underwent successful ictal SPECT acquisition in the process of surgical treatment of intractable partial epilepsy. Thirteen patients were identified who met inclusion criteria for confident seizure localization from either intracranial electroencephalogram recordings or epilepsy surgery outcome. In these cases, ictal scans were registered to an in-house-developed normal SPECT atlas composed of 14 spatially normalized brains of normal subjects. SPM96 was used to test on a voxel-by-voxel basis for statistically significant increases in blood flow associated with each patient's ictal scan. The results were then mapped back onto the patient's magnetic resonance image (MRI) for final interpretation. Statistical parametric mapping (SPM) analysis of ictal SPECT scans was compared to both conventional visual interpretation and the analysis of subtraction ictal SPECT co-registered to MRI (SISCOM). RESULTS: Ten of 13 patient scans showed localizing focal ictal increases in regional cerebral blood flow, all of which were concordant with ultimate epilepsy localization. Of the 3 cases not localized with SPM, 1 was localized by conventional visual interpretation and another, not localized by visual interpretation, was correctly localized with SISCOM. Two cases not localized by SISCOM were localized by both visual and SPM analysis. CONCLUSIONS: This work provides supportive evidence for proof of principle that SPM can be used to provide objective, accurate analysis of ictal SPECT scans in patients with extratemporal lobe epilepsy. 相似文献
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目的 :观察不同部位静脉注射对无痛人工流产术的影响。方法 :随机将 2 0 0例要求行无痛人工流产术的患者分成二组 ,一组静脉注射部位为手背静脉组 ,另一组静脉注射部位为肘部浅静脉 (贵要静脉或肘正中静脉 )组 ,观察静脉推注异丙酚时患者的注射部位有无疼痛症状。结果 :肘部浅静脉注射部位疼痛感明显轻于手背静脉 ,肘部浅静脉注射部位的麻醉起效时间快于手背静脉 ,两组差异有显著性 (P <0 0 5 )。结论 :选择肘部浅静脉注射异丙酚可减轻患者注射部位的疼痛 ,可在短时间内取得理想的麻醉效果。 相似文献
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不同剂量环孢素A对肾移植病人精液质量的影响 总被引:3,自引:3,他引:0
目的 :探讨不同治疗剂量环孢素A(CsA)对肾移植病人精液主要参数和精子形态学的影响。 方法 :对 18例应用不同治疗剂量CsA的肾移植病人的精液进行主要参数和精子形态学分析 ,并与 12例正常男性精液进行比较。 结果 :CsA剂量在 1.5~ 3.0mg·Kg-1·d-1及 3.1~ 5 .5mg·Kg-1·d-1时 ,病人精液的主要参数与正常男性精液比较差异无显著性 (P >0 .0 5 ) ,但病人正常形态精子百分率与正常男性相比差异有显著性 (P <0 .0 5 )。结论 :不同治疗剂量的CsA对肾移植病人的精液主要参数无明显影响 ,但对精子形态可能有一定的影响。 相似文献
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Emma J. Birks MRCP Magdi H. Yacoub DSc FRS Ani Anyanwu FRCS Rosemary Radley Smith FRCP Nicholas R. Banner FRCP Asghar Khaghani FRCS 《The Journal of heart and lung transplantation》2004,23(12):3688-1344
BACKGROUND: Transplantation for patients with a high pulmonary vascular resistance (PVR) carries an increased risk of mortality and right heart failure following heart transplantation and continues to be a major problem. We evaluated the use of hearts from patients who underwent heart and lung transplantation for primary pulmonary hypertension (PPH) as part of a domino procedure because these hearts have hypertrophied right ventricles used to increased pulmonary pressures, but could have a compromised left ventricle or irreversible damage of the right ventricle. METHODS: We reviewed 12 patients with PVR >4 Wood units who underwent orthotopic heart transplantation between 1989 and 1998 using hearts from donors with PPH as part of a domino procedure. RESULTS: We studied 10 men and 2 women, mean age 42.9 years. Mean PVR was 5.3 (range, 4-9) Wood units. Mean ischemia time was 85.3 minutes, and mean donor age was 32 years. Actuarial survival was 75% at 1 year and 75% at 5 years. In the early post-operative period, 3 patients had temporary arrhythmias, 2 required permanent pacemaker implantation, 1 had atrial fibrillation, and 1 had ventricular tachycardia that required defibrillator implantation. At a mean follow-up of 7.8 years, 2 patients had developed asymptomatic transplant coronary disease (both at 8.5 years after transplantation), 1 moderate and 1 very mild; the rest had none. Mean left ventricular ejection fraction at latest follow-up was 70.1% (range, 63%-78%). Right ventricular function assessed clinically and by echocardiography was adequate in the short and long term. CONCLUSIONS: Our results suggest that heart and lung recipients with PPH can provide useful donor hearts to patients with increased PVR and that these hearts function well in the intermediate and long term. 相似文献
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Abstract – Dental injuries are common following facial trauma. This article presents a rare injury: the dislocation of a third molar into the maxillary sinus after complex mandibular and maxillary tuberosity fractures. The possible mechanism and clinical treatment are discussed. 相似文献
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